Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Peter J. Coote"'
Publikováno v:
Antibiotics, Vol 13, Iss 2, p 177 (2024)
The aims of this study were (i) to determine if the combination of mitomycin C with pentamidine or existing antibiotics resulted in enhanced efficacy versus infections with MDR P. aeruginosa in vivo; and (ii) to determine if the doses of mitomycin C
Externí odkaz:
https://doaj.org/article/21d557c269b644ae80c16e0acc39065d
Publikováno v:
Antibiotics, Vol 12, Iss 8, p 1236 (2023)
The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P. aeruginosa and (ii) determine if pentamidine acts as an efflux-pum
Externí odkaz:
https://doaj.org/article/f1eba168de524788b7d33e82ca182dd5
Publikováno v:
Antibiotics, Vol 11, Iss 11, p 1467 (2022)
The aim of the study was to determine the efficacy of carbapenem-only combination treatments derived from four approved drugs (meropenem, doripenem, ertapenem and imipenem) against a MDR strain of P. aeruginosa in a Galleria mellonella larvae infecti
Externí odkaz:
https://doaj.org/article/5d21b277f3894d0face3a35a0db06b4b
Autor:
Sukanlaya Leejae, Supayang Piyawan Voravuthikunchai, Peter J. Coote, Julalak C. Ontong, Thanyaluck Siriyong, Sakol Suwalak
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 919-924 (2020)
Toxicology Reports, Vol 7, Iss, Pp 919-924 (2020)
Graphical abstract
Highlights • Rhodomyrtone, a bioactive acylphloroglucinol compound isolated from the leaves of Rhodomyrtus tomentosa, has been scientifically evidenced as a potential antibacterial agent. • Rhodomyrtone did not cause any s
Highlights • Rhodomyrtone, a bioactive acylphloroglucinol compound isolated from the leaves of Rhodomyrtus tomentosa, has been scientifically evidenced as a potential antibacterial agent. • Rhodomyrtone did not cause any s
Autor:
Thanyaluck Siriyong, Rachael M. Murray, Benjamin J. Parcell, Simon A. Young, Lucy E. Bidgood, Florence Wright, Supayang Piyawan Voravuthikunchai, Peter J. Coote
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
The aim of the study was to determine the efficacy of dual β-lactam combination treatments derived from eight approved drugs against Galleria mellonella larvae infected with MDR strains of P. aeruginosa. Carbapenem-resistant P. aeruginosa NCTC 13437
Publikováno v:
Pathogens and Disease. 78
Funding: University of St Andrews. Multi-drug resistant (MDR) Klebsiella pneumoniae represent a global threat to healthcare due to lack of effective treatments and high mortality rates. The aim of this research was to explore the potential of adminis
Staphylococcus aureusis a major opportunistic pathogen that is exposed to antimicrobial innate immune effectors and antibiotics that can disrupt its cell membrane. An understanding ofS. aureuslipid composition and its role in defending the cell again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d28e6beca9110dcdc435c006d5ce2ee
https://doi.org/10.1101/593483
https://doi.org/10.1101/593483
Autor:
Frances M. Entwistle, Peter J. Coote
Funding information: University of St Andrews. Purpose: To evaluate the suitability of Galleria mellonella larvae as an in vivo model and drug-screening tool for mycobacteria infections. Methodology: Larvae were infected using a range of inoculum siz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12833c51d0531dbc3333636aa177d32b
https://hdl.handle.net/10023/16240
https://hdl.handle.net/10023/16240
Publikováno v:
International Journal of Antimicrobial Agents. 43:254-261
The aim of this study was to determine whether Galleria mellonella larvae can be used (i) as an in vivo infection model for Pseudomonas aeruginosa and (ii) for evaluating the pharmacokinetics and efficacy of antipseudomonal antibiotics. Two strains o
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases. 32:1055-1062
The objective of this study was to determine whether combinations of antimicrobial peptides (AMPs) with caspofungin display enhanced antifungal activity versus Candida albicans in vitro and in vivo. Three conventional AMPs that satisfied criteria fav