Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Peter J. Chen"'
Autor:
Quanjiang Ji, Peter J. Chen, Guangrong Qin, Xin Deng, Ziyang Hao, Zdzislaw Wawrzak, Won-Sik Yeo, Jenny Winjing Quang, Hoonsik Cho, Guan-Zheng Luo, Xiaocheng Weng, Qiancheng You, Chi-Hao Luan, Xiaojing Yang, Taeok Bae, Kunqian Yu, Hualiang Jiang, Chuan He
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisatio
Externí odkaz:
https://doaj.org/article/982278f7c02745b09c2db25ee3867b43
Autor:
Quanjiang Ji, Peter J. Chen, Guangrong Qin, Xin Deng, Ziyang Hao, Zdzislaw Wawrzak, Won-sik Yeo, Jenny Winjing Quang, Hoonsik Cho, Guan-Zheng Luo, Xiaocheng Weng, Qiancheng You, Chi-Hao Luan, Xiaojing Yang, Taeok Bae, Kunqian Yu, Hualiang Jiang, Chuan He
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7: Article number:11000 (2016); Published 18 March 2016: Updated 6 February 2017 In this Article, we presented a structural and functional characterization of the WalKR two-component system for signal transduction and a small mo
Externí odkaz:
https://doaj.org/article/2233302e69b14a45af7c67bc327b8c11
Autor:
Peter J. Chen, David R. Liu
Publikováno v:
Nature Reviews Genetics. 24:161-177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c99dd0de35640a1a5b30f7e4d5219f
https://doi.org/10.1038/s41576-022-00541-1
https://doi.org/10.1038/s41576-022-00541-1
Autor:
Jessie R. Davis, Samagya Banskota, Jonathan M. Levy, Gregory A. Newby, Xiao Wang, Andrew V. Anzalone, Andrew T. Nelson, Peter J. Chen, Andrew D. Hennes, Meirui An, Heejin Roh, Peyton B. Randolph, Kiran Musunuru, David R. Liu
Publikováno v:
Nature Biotechnology.
Realizing the promise of prime editing for the study and treatment of genetic disorders requires efficient methods for delivering prime editors (PEs) in vivo. Here we describe the identification of bottlenecks limiting adeno-associated virus (AAV)-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1c52b9af05a263092511313fbc5d3a5
https://doi.org/10.1038/s41587-023-01758-z
https://doi.org/10.1038/s41587-023-01758-z
Autor:
Chang Li, Aphrodite Georgakopoulou, Gregory A Newby, Peter J Chen, Kelcee A Everette, Kiriaki Paschoudi, Efthimia Vlachaki, Sucheol Gil, Anna K Anderson, Theodore Koob, Lishan Huang, Hongjie Wang, Hans-Peter Kiem, David R Liu, Evangelia Yannaki, André Lieber
Publikováno v:
Blood.
Sickle Cell Disease (SCD) is a monogenic disease caused by a nucleotide mutation in the β-globin gene. Current gene therapy studies are mainly focused on lentivirus vector-mediated gene addition or CRISPR/Cas9-mediated fetal globin reactivation, lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30af570cb24ad7ab980dfcad37b6d63b
https://doi.org/10.1182/blood.2022018252
https://doi.org/10.1182/blood.2022018252
Autor:
Alvin Hsu, Andrew V. Anzalone, Peyton B. Randolph, James W. Nelson, Simon P. Shen, Kelcee A. Everette, Meirui An, Gregory A. Newby, David R. Liu, Peter J. Chen, Jonathan C. Chen
Publikováno v:
Nature Biotechnology. 40:402-410
Prime editing enables the installation of virtually any combination of point mutations, small insertions or small deletions in the DNA of living cells. A prime editing guide RNA (pegRNA) directs the prime editor protein to the targeted locus and also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b10210353dfc4e217eed08131ecc552b
https://doi.org/10.1038/s41587-021-01039-7
https://doi.org/10.1038/s41587-021-01039-7
Publikováno v:
Nature biotechnology
N6-methyladenosine (m6A) is the most widespread internal mRNA modification in humans. Despite recent progress in understanding the biological roles of m6A, the inability to install m6A site-specifically in individual transcripts has hampered efforts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e499c65a1815adb6e1743c7db5aade0
http://europepmc.org/articles/PMC7718427
http://europepmc.org/articles/PMC7718427
Publikováno v:
Nat Protoc
Prime editing (PE) is a precision gene editing technology that enables the programmable installation of substitutions, insertions, and deletions in cells and animals without requiring double-strand DNA breaks (DSBs). The mechanism of prime editing ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c39d68263bd43ad5fb6cea1e62af503
https://pubmed.ncbi.nlm.nih.gov/35941224
https://pubmed.ncbi.nlm.nih.gov/35941224
Autor:
Luke W. Koblan, Peter J. Chen, Alexander A. Sousa, Aditya Raguram, Peyton B. Randolph, Gregory A. Newby, Jonathan M. Levy, Andrew V. Anzalone, Christine D. Wilson, David R. Liu, Jessie Rose Davis
Publikováno v:
Nature
Most genetic variants that contribute to disease1 are challenging to correct efficiently and without excess byproducts2-5. Here we describe prime editing, a versatile and precise genome editing method that directly writes new genetic information into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a837c29b98029c95efdb2491661af0
https://doi.org/10.1038/s41586-019-1711-4
https://doi.org/10.1038/s41586-019-1711-4
Autor:
James W, Nelson, Peyton B, Randolph, Simon P, Shen, Kelcee A, Everette, Peter J, Chen, Andrew V, Anzalone, Meirui, An, Gregory A, Newby, Jonathan C, Chen, Alvin, Hsu, David R, Liu
Publikováno v:
Nature biotechnology. 40(3)
Prime editing enables the installation of virtually any combination of point mutations, small insertions or small deletions in the DNA of living cells. A prime editing guide RNA (pegRNA) directs the prime editor protein to the targeted locus and also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c0c6d00438956b73ad8d027f9f5b9c1
https://pubmed.ncbi.nlm.nih.gov/34880468
https://pubmed.ncbi.nlm.nih.gov/34880468