Tubastatin A prevents hemorrhage-induced endothelial barrier dysfunction

Autor: Hasan B. Alam, Zhigang Chang, Yongqing Li, Martin Sillesen, Vahagn C. Nikolian, Peter J. Bruhn, Baoling Liu, Ihab Halaweish

Publikováno v: Journal of Trauma and Acute Care Surgery. 84:386-392

Background Microvascular hyperpermeability resulting from endothelial barrier dysfunction (EBD) is associated with worse clinical outcomes in trauma-induced hemorrhagic shock. We have previously shown that treatment with Tubastatin A (TubA), a histon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92a1edf50347f5de03ece7bc8d3a0b4
https://doi.org/10.1097/ta.0000000000001753

Histone deactylase gene expression profiles are associated with outcomes in blunt trauma patients

Autor: Simone E. Dekker, Jens Hillingsø, Rasmus Fabricius, Peter Svenningsen, Lars Bo Svendsen, Ted Bambakidis, Martin Sillesen, Hasan B. Alam, Peter J. Bruhn

Publikováno v: Sillesen, M, Bambakidis, T, Dekker, S E, Fabricius, R, Svenningsen, P, Bruhn, P J, Svendsen, L B, Hillingso, J & Alam, H B 2016, ' Histone deactylase gene expression profiles are associated with outcomes in blunt trauma patients ', Journal of Trauma and Acute Care Surgery, vol. 80, no. 1, pp. 26-33 . https://doi.org/10.1097/TA.0000000000000896
Journal of Trauma and Acute Care Surgery, 80(1), 26-33. Lippincott Williams and Wilkins

BACKGROUND Treatment with histone deacetylase (HDAC) inhibitors, such as valproic acid, increases survival in animal models of trauma and sepsis. Valproic acid is a pan-inhibitor that blocks most of the known HDAC isoforms. Targeting individual HDAC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabd58c86cd3236eba4d43c7aa3cf68a
https://doi.org/10.1097/ta.0000000000000896

Posttraumatic levels of liver enzymes can reduce the need for CT in children: a retrospective cohort study

Autor: Frederik Helgstrand, Jens Hillingsø, Lars Bo Svendsen, Peter J. Bruhn, Lene Østerballe

Publikováno v: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Background Computed tomography (CT) is the gold standard in the initial evaluation of the hemodynamically stable patient with suspected liver trauma. However, the adverse effects of radiation exposure are of specific concern in the pediatric populati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739daa80039b254b01e1d50b81ba7275
https://pubmed.ncbi.nlm.nih.gov/27561373

Pharmacologic Resuscitation Decreases Blood-Brain Barrier Permeability in a Porcine Model of Traumatic Brain Injury and Hemorrhagic Shock

Autor: Anuska V. Andjelkovic, Baoling Liu, Patrick E. Georgoff, Vahagn C. Nikolian, Peter J. Bruhn, Simone E. Dekker, Yonqing Li, Baihong Pan, Hasan B. Alam, Ted Bambakidis

Publikováno v: Journal of the American College of Surgeons. 223:S83

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42ed884e5c29f2de41c2b1410615ed8b
https://doi.org/10.1016/j.jamcollsurg.2016.06.162