Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Peter J. Brophy"'
Autor:
Sam A. Booker, Laura Simões de Oliveira, Natasha J. Anstey, Zrinko Kozic, Owen R. Dando, Adam D. Jackson, Paul S. Baxter, Lori L. Isom, Diane L. Sherman, Giles E. Hardingham, Peter J. Brophy, David J.A. Wyllie, Peter C. Kind
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 107988- (2020)
Summary: Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segmen
Externí odkaz:
https://doaj.org/article/43e9885c0bb64e499d98b5c2d2ae7c83
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
The process of myelination in the nervous system requires a coordinated formation of both transient and stable supramolecular complexes. Myelin-specific proteins play key roles in these assemblies, which may link membranes to each other or connect th
Externí odkaz:
https://doaj.org/article/ecc9740733984edaa4a67861d164e7a8
Autor:
Diane L. Sherman, Peter J. Brophy
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Charcot-Marie-Tooth (CMT) disease comprises up to 80 monogenic inherited neuropathies of the peripheral nervous system (PNS) that collectively result in demyelination and axon degeneration. The majority of CMT disease is primarily either dysmyelinati
Externí odkaz:
https://doaj.org/article/d6885672df6a4ba4953a26076f9cfb61
Autor:
Peter J. Brophy
Publikováno v:
Myelin ISBN: 9780203746141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c95d0bd810e99974aabb3d7fa0e91547
https://doi.org/10.1201/9780203746141-8
https://doi.org/10.1201/9780203746141-8
Autor:
Peter J. Brophy, Michele Zagnoni, Diane L. Sherman, Daniel G Booth, Aniket Ghosh, Elise L.V. Malavasi
Publikováno v:
eLife
Malavasi, E, Ghosh, A, Booth, D, Zagnoni, M, Sherman, D & Brophy, P J 2021, ' Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons ', eLIFE, vol. 10, e68089 . https://doi.org/10.7554/eLife.68089
eLife, Vol 10 (2021)
Malavasi, E, Ghosh, A, Booth, D, Zagnoni, M, Sherman, D & Brophy, P J 2021, ' Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons ', eLIFE, vol. 10, e68089 . https://doi.org/10.7554/eLife.68089
eLife, Vol 10 (2021)
Voltage-gated sodium channels cluster in macromolecular complexes at nodes of Ranvier to promote rapid nerve impulse conduction in vertebrate nerves. Node assembly in peripheral nerves is thought to be initiated at heminodes at the extremities of mye
Autor:
Małgorzata Rydzanicz, Peter J. Brophy, Joanna Kosińska, Anna Biernacka, Robert Smigiel, Dorota Mikolajkow, Barbara Królak-Olejnik, Maria M. Sasiadek, Diane L. Sherman, Anna Walczak, Witalij Andrzejewski, Rafał Płoski, Paweł Krajewski, Maria Boczar, Malgorzata Marciniak, Piotr Gasperowicz, Piotr Stawiński
Publikováno v:
Human Molecular Genetics
Smigiel, R, Sherman, D L, Rydzanicz, M, Walczak, A, Mikolajkow, D, Krolak-Olejnik, B, Kosinska, J, Gasperowicz, P, Biernacka, A, Stawinski, P, Marciniak, M, Andrzejewski, W, Boczar, M, Krajewski, P, Sasiadek, M M, Brophy, P J & Ploski, R 2018, ' Homozygous mutation in the Neurofascin gene affecting the glial isoform of Neurofascin causes severe neurodevelopment disorder with hypotonia, amimia and areflexia ', Human Molecular Genetics, vol. 27, no. 21, pp. 3669–3674 . https://doi.org/10.1093/hmg/ddy277
Smigiel, R, Sherman, D L, Rydzanicz, M, Walczak, A, Mikolajkow, D, Krolak-Olejnik, B, Kosinska, J, Gasperowicz, P, Biernacka, A, Stawinski, P, Marciniak, M, Andrzejewski, W, Boczar, M, Krajewski, P, Sasiadek, M M, Brophy, P J & Ploski, R 2018, ' Homozygous mutation in the Neurofascin gene affecting the glial isoform of Neurofascin causes severe neurodevelopment disorder with hypotonia, amimia and areflexia ', Human Molecular Genetics, vol. 27, no. 21, pp. 3669–3674 . https://doi.org/10.1093/hmg/ddy277
The Neurofascins (NFASCs) are a family of proteins encoded by alternative transcripts of NFASC that cooperate in the assembly of the node of Ranvier in myelinated nerves. Differential expression of NFASC in neurons and glia presents a remarkable exam
Autor:
Markus H. Schwab, Tatjana Kleele, Stefan Engelhardt, Yan Xiao, Thomas Misgeld, Tim Czopka, Diane L. Sherman, Monika S. Brill, Gabriela Plucińska, Matthias Kneussel, Peter J. Brophy, Mengzhe Wang, Petros Avramopoulos
Publikováno v:
The journal of cell biology 220(4), e201911114 (2021). doi:10.1083/jcb.201911114
Wang, M, Kleele, T, Xiao, Y, Plucinska, G, Avramopoulos, P, Engelhardt, S, Schwab, M H, Kneussel, M, Czopka, T, Sherman, D, Brophy, P J, Misgeld, T & Brill, M S 2021, ' Completion of neuronal remodeling prompts myelination along developing motor axon branches ', Journal of Cell Biology . https://doi.org/10.1083/jcb.201911114
The Journal of Cell Biology
Wang, M, Kleele, T, Xiao, Y, Plucinska, G, Avramopoulos, P, Engelhardt, S, Schwab, M H, Kneussel, M, Czopka, T, Sherman, D, Brophy, P J, Misgeld, T & Brill, M S 2021, ' Completion of neuronal remodeling prompts myelination along developing motor axon branches ', Journal of Cell Biology . https://doi.org/10.1083/jcb.201911114
The Journal of Cell Biology
Postnatal motor neurons undergo extensive competitive remodeling and synchronously myelinate. Wang et al. now reveal that axon remodeling and myelination intersect. While myelination does not predetermine competition outcome, completing remodeling al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb1d60a36096529a25017c77f4762a1
Publikováno v:
Ghosh, A, Malavasi, E LV, Sherman, D L & Brophy, P J 2020, ' Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment ', eLIFE, vol. 9, e60619, pp. 1-17 . https://doi.org/10.7554/eLife.60619
eLife, Vol 9 (2020)
eLife
eLife, Vol 9 (2020)
eLife
Ion channel complexes promote action potential initiation at the mammalian axon initial segment (AIS), and modulation of AIS size by recruitment or loss of proteins can influence neuron excitability. Although endocytosis contributes to AIS turnover,