Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Peter J. Brophy"'
Autor:
Sam A. Booker, Laura Simões de Oliveira, Natasha J. Anstey, Zrinko Kozic, Owen R. Dando, Adam D. Jackson, Paul S. Baxter, Lori L. Isom, Diane L. Sherman, Giles E. Hardingham, Peter J. Brophy, David J.A. Wyllie, Peter C. Kind
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 107988- (2020)
Summary: Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segmen
Externí odkaz:
https://doaj.org/article/43e9885c0bb64e499d98b5c2d2ae7c83
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
The process of myelination in the nervous system requires a coordinated formation of both transient and stable supramolecular complexes. Myelin-specific proteins play key roles in these assemblies, which may link membranes to each other or connect th
Externí odkaz:
https://doaj.org/article/ecc9740733984edaa4a67861d164e7a8
Autor:
Diane L. Sherman, Peter J. Brophy
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Charcot-Marie-Tooth (CMT) disease comprises up to 80 monogenic inherited neuropathies of the peripheral nervous system (PNS) that collectively result in demyelination and axon degeneration. The majority of CMT disease is primarily either dysmyelinati
Externí odkaz:
https://doaj.org/article/d6885672df6a4ba4953a26076f9cfb61
Autor:
Elise LV Malavasi, Aniket Ghosh, Daniel G Booth, Michele Zagnoni, Diane L Sherman, Peter J Brophy
Publikováno v:
eLife, Vol 10 (2021)
Voltage-gated sodium channels cluster in macromolecular complexes at nodes of Ranvier to promote rapid nerve impulse conduction in vertebrate nerves. Node assembly in peripheral nerves is thought to be initiated at heminodes at the extremities of mye
Externí odkaz:
https://doaj.org/article/ee3ad2630ccd4a97998b967b97a6921c
Publikováno v:
eLife, Vol 9 (2020)
Ion channel complexes promote action potential initiation at the mammalian axon initial segment (AIS), and modulation of AIS size by recruitment or loss of proteins can influence neuron excitability. Although endocytosis contributes to AIS turnover,
Externí odkaz:
https://doaj.org/article/932b8fb6df2549ddac51a9143d0ca06f
Autor:
Sophie B Siems, Olaf Jahn, Maria A Eichel, Nirmal Kannaiyan, Lai Man N Wu, Diane L Sherman, Kathrin Kusch, Dörte Hesse, Ramona B Jung, Robert Fledrich, Michael W Sereda, Moritz J Rossner, Peter J Brophy, Hauke B Werner
Publikováno v:
eLife, Vol 9 (2020)
Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin. Despite the relevance of the peripheral nervous system for normal sensory and motor capabiliti
Externí odkaz:
https://doaj.org/article/0ee8234d2e754139a9f492fe22e31c0d
Autor:
Peter J. Brophy
Publikováno v:
Myelin ISBN: 9780203746141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c95d0bd810e99974aabb3d7fa0e91547
https://doi.org/10.1201/9780203746141-8
https://doi.org/10.1201/9780203746141-8
Autor:
Veronique Amor, Chuansheng Zhang, Anna Vainshtein, Ao Zhang, Daniel R Zollinger, Yael Eshed-Eisenbach, Peter J Brophy, Matthew N Rasband, Elior Peles
Publikováno v:
eLife, Vol 6 (2017)
A high density of Na+ channels at nodes of Ranvier is necessary for rapid and efficient action potential propagation in myelinated axons. Na+ channel clustering is thought to depend on two axonal cell adhesion molecules that mediate interactions betw
Externí odkaz:
https://doaj.org/article/d413c2b8c31449edb49d2a41b7f1a9d2
Autor:
Roberta Noseda, Marta Guerrero-Valero, Valeria Alberizzi, Stefano C Previtali, Diane L Sherman, Marilena Palmisano, Richard L Huganir, Klaus-Armin Nave, Ana Cuenda, Maria Laura Feltri, Peter J Brophy, Alessandra Bolino
Publikováno v:
PLoS Biology, Vol 14, Iss 4, p e1002440 (2016)
Microtubule-based kinesin motors have many cellular functions, including the transport of a variety of cargos. However, unconventional roles have recently emerged, and kinesins have also been reported to act as scaffolding proteins and signaling mole
Externí odkaz:
https://doaj.org/article/0c85f8955fe04ce2ad1d8bafe0230402
Autor:
Peter J. Brophy, Michele Zagnoni, Diane L. Sherman, Daniel G Booth, Aniket Ghosh, Elise L.V. Malavasi
Publikováno v:
eLife
Malavasi, E, Ghosh, A, Booth, D, Zagnoni, M, Sherman, D & Brophy, P J 2021, ' Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons ', eLIFE, vol. 10, e68089 . https://doi.org/10.7554/eLife.68089
eLife, Vol 10 (2021)
Malavasi, E, Ghosh, A, Booth, D, Zagnoni, M, Sherman, D & Brophy, P J 2021, ' Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons ', eLIFE, vol. 10, e68089 . https://doi.org/10.7554/eLife.68089
eLife, Vol 10 (2021)
Voltage-gated sodium channels cluster in macromolecular complexes at nodes of Ranvier to promote rapid nerve impulse conduction in vertebrate nerves. Node assembly in peripheral nerves is thought to be initiated at heminodes at the extremities of mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1d661eac0950969f89b0d20def9075
http://europepmc.org/articles/PMC8289411
http://europepmc.org/articles/PMC8289411