Výsledky vyhledávání - "Peter J. Alcock"

Potent Cyclic Monomeric and Dimeric Peptide Inhibitors of VLA-4 (?4?1 Integrin)-Mediated Cell Adhesion Based on the Ile-Leu-Asp-Val Tetrapeptide

Autor: Anand S. Dutta, Amanda Rees, Alec Jamieson, Duncan Haworth, Rod S. Kittlety, Lorraine A. Hassall, Paul Gellert, James J. Gormley, Christopher F. Reilly, Peter J. Alcock, Christopher F. Hayward, Linda J. Wood, Mandy L. Crowther, Julie M. Moores

Publikováno v: Journal of Peptide Science. 6:321-341

Potent monomeric and dimeric cyclic peptide very late antigen-4 (VLA-4) inhibitors have been designed based on a tetrapeptide (Ile-Leu-Asp-Val) sequence present in a 25-amino acid peptide (CS-1) reported in the literature. The peptides, synthesized b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25ceb93494fef4de3a60f6b947f394cc
https://doi.org/10.1002/1099-1387(200007)6:7<321::aid-psc259>3.0.co

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Potent cyclic peptide inhibitors of VLA-4 (?4?1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-d-Arg-d-Arg) (ZD7349) compatible with depot formulation

Autor: Paul Gellert, Peter J. Alcock, Duncan Haworth, Anand S. Dutta, Tracy Halterman, Roger Ferguson, Linda J. Wood, Julie M. Moores, Lorraine A. Hassall, Christopher F. Hayward, James J. Gormley, Christopher F. Reilly, Matthew M Coath, Jackie Moors, Amanda Rees, Rod S. Kittlety, Alec Jamieson

Publikováno v: Journal of Peptide Science. 6:398-412

Additional structure–activity relationship studies on potent cyclic peptide inhibitors of very late antigen-4 (VLA-4) are reported. The new N- to C-terminal cyclic hexa-, hepta- and octapeptide inhibitors like cyclo(MeIle/MePhe-Leu-Asp-Val-X) (X=2�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76652a961e3b5a12e5486a93642eb39f
https://doi.org/10.1002/1099-1387(200008)6:8<398::aid-psc270>3.0.co

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Anti-inflammatory activity of c(ILDV-NH(CH2)5CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion

Autor: Peter J. Alcock, Amanda Rees, Anand S. Dutta, Alec Jamieson, Christopher F. Reilly, Duncan Haworth, Huw B Jones, Linda J. Wood, James J. Gormley

Publikováno v: British Journal of Pharmacology. 126:1751-1760

1. Small, N- to C-terminal cyclized peptides containing the leucyl-aspartyl-valine (LDV) motif from fibronectin connecting segment-1 (CS-1) have been investigated for their effects on the adhesion of human T-lymphoblastic leukaemia cells (MOLT-4) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8964fddd9cfecc984eabca246c2f17c6
https://doi.org/10.1038/sj.bjp.0702511

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High-throughput screening of RNA polymerase inhibitors using a fluorescent UTP analog

Autor: M. N. Harish, Shubhada Barde, Umender Sharma, Suresh Solapure, Peter J. Alcock, Jyothi Bhat, Rajendra Rane, Sarah Lamb, Raman K. Roy, Dhiman Sarkar, Steve Peters, Darren Plant

Publikováno v: Journal of biomolecular screening. 11(8)

RNA polymerase (RNAP) is a well-validated target for the development of antibacterial and antituberculosis agents. Because the purification of large quantities of native RNA polymerase from pathogenic mycobacteria is hazardous and cumbersome, the pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecdf481843d4eab2e0044665d60aaec
https://pubmed.ncbi.nlm.nih.gov/17021309

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