Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Peter J van den Elsen"'
Autor:
Rob C M de Jong, Mark M Ewing, Margreet R de Vries, Jacco C Karper, Antonius J N M Bastiaansen, Hendrika A B Peters, Fabiana Baghana, Peter J van den Elsen, Céline Gongora, J Wouter Jukema, Paul H A Quax
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185820 (2017)
Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor kappa-beta (NFκB)-mediated inflammation, which drives post-interventional intimal hyperpl
Externí odkaz:
https://doaj.org/article/7fba7a515cb24939b510a5d62c71ae04
Autor:
T Huibertus van Essen, Sake I van Pelt, Inge H G Bronkhorst, Mieke Versluis, Fariba Némati, Cécile Laurent, Gregorius P M Luyten, Thorbald van Hall, Peter J van den Elsen, Pieter A van der Velden, Didier Decaudin, Martine J Jager
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164292 (2016)
Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and increased human leukocyte antigen (HLA) expression, carry an increased risk of death due to metastases. These tumors should be ideal for T-cell based the
Externí odkaz:
https://doaj.org/article/81eba8a66d0847c4b825c012cde07949
Autor:
Peter J van den Elsen
Publikováno v:
Frontiers in Immunology, Vol 2 (2011)
MHC-I and MHC-II molecules play an essential role in the immune response to pathogens by virtue of their ability to present peptides to CD8+ and CD4+ T cells, respectively. Given this critical role, MHC-I and MHC-II genes are regulated in a tight fas
Externí odkaz:
https://doaj.org/article/5043276d97b84a3db225a604605748c7
Publikováno v:
Vijayan, S, Sidiq, T, Yousuf, S, van den Elsen, P J & Kobayashi, K S 2019, ' Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance ', Immunogenetics, vol. 71, no. 3, pp. 273-282 . https://doi.org/10.1007/s00251-019-01106-z
Major histocompatibility complex (MHC) class I and class II molecules play critical roles in the activation of the adaptive immune system by presenting antigens to CD8+ and CD4+ T cells, respectively. Although it has been well known that CIITA (MHC c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205855ff2ca28952506eaf2c8cb0c624
https://doi.org/10.1007/s00251-019-01106-z
https://doi.org/10.1007/s00251-019-01106-z
Autor:
Marion H. König, Hans Gelderblom, N.G. Dekker-Ensink, Peter J. K. Kuppen, Anniek Zaalberg, Marloes Swets, Peter J. van den Elsen, Cornelis J.H. van de Velde
Publikováno v:
Human Immunology, 77(9), 773-779
Swets, M, Koenig, M H, Zaalberg, A, Dekker-Ensink, N G, Gelderblom, H, van de Velde, C J H, van den Elsen, P J & Kuppen, P J K 2016, ' HLA-G and classical HLA class I expression in primary colorectal cancer and associated liver metastases ', Human Immunology, vol. 77, no. 9, pp. 773-779 . https://doi.org/10.1016/j.humimm.2016.03.001
Human Immunology, 77(9), 773-779. Elsevier Inc.
Swets, M, Koenig, M H, Zaalberg, A, Dekker-Ensink, N G, Gelderblom, H, van de Velde, C J H, van den Elsen, P J & Kuppen, P J K 2016, ' HLA-G and classical HLA class I expression in primary colorectal cancer and associated liver metastases ', Human Immunology, vol. 77, no. 9, pp. 773-779 . https://doi.org/10.1016/j.humimm.2016.03.001
Human Immunology, 77(9), 773-779. Elsevier Inc.
De novo expression of HLA-G has been demonstrated in colorectal cancer. HLA-G, amongst others, inhibits natural killer cell function, contributing to host immune defense evasion. Another mechanism to escape anti-tumor immunity is loss of HLA class I.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f219f6fea10809148b2c6b6443228a7b
https://doi.org/10.1016/j.humimm.2016.03.001
https://doi.org/10.1016/j.humimm.2016.03.001
Autor:
Belinda W. C. Ommering, Peter J. van den Elsen, Jolanda van der Zee, Friedo W. Dekker, Carolina R. Jost
Publikováno v:
Medical Science Educator
Physician-scientists are urgently needed to make progress in the dynamic world of medical healthcare. Currently, there is a worldwide shortage in physicians pursuing a scientific career. Actively engaging students in research in early stages of medic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357f0757eec6d05a87fb56928b556e32
https://hdl.handle.net/1887/95402
https://hdl.handle.net/1887/95402
Autor:
Ruud H. Wijdeven, Annet F Wierenga-Wolf, Jimmy J Akkermans, Jacques Neefjes, Peter J. van den Elsen, Rogier Q. Hintzen, Marvin M van Luijn
Publikováno v:
EMBO Reports, 19(9):e45553. Wiley-Blackwell
EMBO Reports, 19(9)
EMBO Reports
EMBO Reports, 19(9)
EMBO Reports
The cytokine interferon‐γ (IFNγ) can induce expression of MHC class II (MHCII) on many different cell types, leading to antigen presentation to CD4(+) T cells and immune activation. This has also been linked to anti‐tumour immunity and graft‐
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615b545fa94ac8548e630d4784d80c98
https://pure.eur.nl/en/publications/99d6341b-17e1-48af-b310-23386656bdc8
https://pure.eur.nl/en/publications/99d6341b-17e1-48af-b310-23386656bdc8
Autor:
Benjamin Drukarch, Micha M.M. Wilhelmus, Anne-Marie van Dam, Joep Killestein, Peter J. van den Elsen, Charlotte E. Teunissen, John J. P. Brevé, Joram van Rossum, Claudia Sestito, Marja C.J.A. van Eggermond
Publikováno v:
Sestito, C, Brevé, J J P, van Eggermond, M C J A, Killestein, J, Teunissen, C E, van Rossum, J, Wilhelmus, M M M, Drukarch, B, van den Elsen, P J & van Dam, A-M 2017, ' Monocyte-derived tissue transglutaminase in multiple sclerosis patients : reflecting an anti-inflammatory status and function of the cells? ', Journal of Neuroinflammation, vol. 14, no. 1, pp. 257 . https://doi.org/10.1186/s12974-017-1035-y
Journal of Neuroinflammation, 14(1). BioMed Central
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-12 (2017)
Journal of Neuroinflammation, 14
Journal of Neuroinflammation, 14(1). BioMed Central
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-12 (2017)
Journal of Neuroinflammation, 14
Background Leukocyte infiltration into the central nervous system is an important feature of multiple sclerosis (MS) pathology. Among the infiltrating cells, monocytes comprise the largest population and are considered to play a dual role in the cour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0c55a6e26184066b2525b06fad86b5
https://doi.org/10.1186/s12974-017-1035-y
https://doi.org/10.1186/s12974-017-1035-y
Autor:
Rutger J. Wierda, Xanne M. Miggelbrink, Erik W. van Zwet, Geert W. Haasnoot, Sacha B. Geutskens, Marieke Goedhart, Alice F. Muggen, Marja C.J.A. van Eggermond, Peter J. van den Elsen
Publikováno v:
Human Immunology. 76:431-437
Monocytes play a key role in immune system function. Chromatin remodeling is crucial for various differentiation and gene regulation processes and is rather well studied in T cells. However, for monocytes not much is known regarding how the epigeneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeb6111b7f39ac00eb7c6bef8da384d6
https://doi.org/10.1016/j.humimm.2015.03.017
https://doi.org/10.1016/j.humimm.2015.03.017
Autor:
Daniëlle Krijgsman, Peter J. van den Elsen, Anne K. Wouters, Cornelis J.H. van de Velde, Jaap D. H. van Eendenburg, Tom van Wezel, Hans Gelderblom, Marloes Swets, Ronald L.P. van Vlierberghe, Arnoud Boot, Peter J. K. Kuppen
Publikováno v:
Clinical immunology (Orlando, Fla.). 194
HLA-G protein expression could play a role in evasion of tumor immune surveillance. Accumulating evidence demonstrates that HLA-G is expressed in different types of malignancies, including colorectal cancer (CRC). The purpose of the current study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1116231565f56930d5af4b31d05432
https://pubmed.ncbi.nlm.nih.gov/30006120
https://pubmed.ncbi.nlm.nih.gov/30006120