Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Peter J Van Santbrink"'
Autor:
Amanda C Foks, Ingrid A Ran, Vanessa Frodermann, Ilze Bot, Peter J van Santbrink, Johan Kuiper, Gijs H M van Puijvelde
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83134 (2013)
OBJECTIVE: Co-stimulatory and co-inhibitory molecules are mainly expressed on T cells and antigen presenting cells and strongly orchestrate adaptive immune responses. Whereas co-stimulatory molecules enhance immune responses, signaling via co-inhibit
Externí odkaz:
https://doaj.org/article/f17c6e22f03242b090de700ba9fdc60e
Autor:
Martine Bot, Paul P Van Veldhoven, Saskia C A de Jager, Jason Johnson, Niels Nijstad, Peter J Van Santbrink, Marijke M Westra, Gerd Van Der Hoeven, Marion J Gijbels, Carsten Müller-Tidow, Georg Varga, Uwe J F Tietge, Johan Kuiper, Theo J C Van Berkel, Jerzy-Roch Nofer, Ilze Bot, Erik A L Biessen
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63360 (2013)
Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(
Externí odkaz:
https://doaj.org/article/1a0d95655b81411ea2e0c24d8f384462
Autor:
Marie A. C. Depuydt, Femke D. Vlaswinkel, Esmeralda Hemme, Lucie Delfos, Mireia N. A. Bernabé Kleijn, Peter J. van Santbrink, Amanda C. Foks, Bram Slütter, Johan Kuiper, Ilze Bot
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mast cells have been associated with the progression and destabilization of advanced atherosclerotic plaques. Reducing intraplaque mast cell accumulation upon atherosclerosis progression could be a potent therapeutic strategy to limit plaque
Externí odkaz:
https://doaj.org/article/f05e69fe5f0f4c9a842ad1a220d94908
Autor:
Ilze Bot, Natalia V. Ortiz Zacarías, Wilhelmus E. A. de Witte, Henk de Vries, Peter J. van Santbrink, Daniël van der Velden, Mara J. Kröner, Dirk-Jan van der Berg, Dean Stamos, Elizabeth C. M. de Lange, Johan Kuiper, Adriaan P. IJzerman, Laura H. Heitman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract CC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number of diseases, including atherosclerosis. Several CCR2 antagonists have been developed as potential therapeutic agents, however their in vivo clinical effic
Externí odkaz:
https://doaj.org/article/be41579bc6074a96b13bbf8097e120c1
Autor:
Hongbo Chi, Frank H. Schaftenaar, Jacob Amersfoort, Yanyan Wang, Estefanía Moreno-Gordaliza, Gijs H.M. van Puijvelde, Ilze Bot, Thomas Hankemeier, Bram Slütter, Peter J. van Santbrink, Johan Kuiper, Amy C. Harms, Hidde Douna, Amanda C. Foks
Publikováno v:
Cardiovascular research
Cardiovascular research, 117(5), 1309-1324
Cardiovascular research, 117(5), 1309-1324
Aims A hallmark of advanced atherosclerosis is inadequate immunosuppression by regulatory T (Treg) cells inside atherosclerotic lesions. Dyslipidemia has been suggested to alter Treg cell migration by affecting the expression of specific membrane pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166b657e0abc98ccb980fb131945aa2d
https://doi.org/10.1093/cvr/cvaa208
https://doi.org/10.1093/cvr/cvaa208
Autor:
Gijs H.M. van Puijvelde, Mara J. Kröner, Louis Boon, Ilze Bot, Peter J. van Santbrink, Johan Kuiper, Vanessa Frodermann, Amanda C. Foks, Jolien Wolbert, Thomas van der Heijden
Publikováno v:
Cardiovascular research, 111(3), 252-261
AIMS\nMyeloid-derived suppressor cells (MDSCs) form a heterogeneous population of cells composed of early myeloid progenitor cells and immature myeloid cells, which strongly suppress pro-inflammatory immune cells in inflammatory diseases. Currently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba75c44fd64ed6c90b2e493fa72b35a
https://doi.org/10.1093/cvr/cvw114
https://doi.org/10.1093/cvr/cvw114
Autor:
Frank H. Schaftenaar, Hidde Douna, Gijs H.M. van Puijvelde, Jacob Amersfoort, Ilze Bot, Peter J. van Santbrink, Amanda C. Foks, Johan Kuiper, Mara J. Kröner
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, 9, 2937
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, 9, 2937
Frontiers in Immunology, Vol 9 (2018)
Macroautophagy (or autophagy) is a conserved cellular process in which cytoplasmic cargo is targeted for lysosomal degradation. Autophagy is crucial for the functional integrity of different subsets of T cells in various developmental stages. Since a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cdc3be080b5b0c0704a0d6adb9a34c3
https://doi.org/10.3389/fimmu.2018.02937
https://doi.org/10.3389/fimmu.2018.02937
Autor:
Stefan R. Havik, Miranda Van Eck, Peter J. van Santbrink, Janine J. Geerling, Geesje M. Dallinga-Thie, Joya E. Nahon, Menno Hoekstra, J.A. Kuivenhoven
Publikováno v:
Atherosclerosis, 279. Elsevier Ireland Ltd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5e69e5e53921248437c0aa047198dd
https://doi.org/10.1016/j.atherosclerosis.2018.09.007
https://doi.org/10.1016/j.atherosclerosis.2018.09.007
Autor:
Wouter Venema, Amanda C. Foks, Eva Kritikou, Peter J. van Santbrink, Ilze Bot, Thomas van der Heijden, Johan Kuiper, Bram Slütter, Janine van Duijn
Objective— Inflammasomes are multiprotein complexes, and their activation has been associated with cardiovascular disease. Inflammasome activation leads to secretion of caspase-1 by innate immune cells, resulting in the activation of interleukin-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab1661323acb895923199db4c892f2b
https://doi.org/10.1161/atvbaha.117.309575
https://doi.org/10.1161/atvbaha.117.309575
Autor:
Mara J. Kröner, Adriaan P. IJzerman, Henk de Vries, Dean Stamos, Elizabeth C. M. de Lange, Ilze Bot, Daniël van der Velden, Wilhelmus E. A. de Witte, Peter J. van Santbrink, Laura H. Heitman, Natalia V. Ortiz Zacarías, Dirk-Jan van der Berg, Johan Kuiper
Publikováno v:
Scientific Reports
Scientific Reports, 2017(7), 52
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, 2017(7), 52
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
CC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number of diseases, including atherosclerosis. Several CCR2 antagonists have been developed as potential therapeutic agents, however their in vivo clinical efficacy was l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8557e1fd3f6a6e2bca8a2b652d9b06a1
https://hdl.handle.net/1887/49661
https://hdl.handle.net/1887/49661