Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Peter J Turnbaugh"'
Publikováno v:
eLife, Vol 12 (2023)
Bacteria within the gut microbiota possess the ability to metabolize a wide array of human drugs, foods, and toxins, but the responsible enzymes for these chemical events remain largely uncharacterized due to the time-consuming nature of current expe
Externí odkaz:
https://doaj.org/article/6ad264401dd84132881e87b5bc89e4eb
Autor:
Cecilia Noecker, Juan Sanchez, Jordan E Bisanz, Veronica Escalante, Margaret Alexander, Kai Trepka, Almut Heinken, Yuanyuan Liu, Dylan Dodd, Ines Thiele, Brian C DeFelice, Peter J Turnbaugh
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002125 (2023)
Human gut bacteria perform diverse metabolic functions with consequences for host health. The prevalent and disease-linked Actinobacterium Eggerthella lenta performs several unusual chemical transformations, but it does not metabolize sugars and its
Externí odkaz:
https://doaj.org/article/4aca52c64575452cb35fdf8e9432cf85
Autor:
Rachel R Rock, Peter J Turnbaugh
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002087 (2023)
Aging is often accompanied by an increased risk of an array of diseases spanning the cardiovascular, nervous, and immune systems, among others. Despite remarkable progress in understanding the cellular and molecular mechanisms involved in aging, the
Externí odkaz:
https://doaj.org/article/21196762d26e48b8b238a1e2ec8be45d
Autor:
Qi Yan Ang, Diana L Alba, Vaibhav Upadhyay, Jordan E Bisanz, Jingwei Cai, Ho Lim Lee, Eliseo Barajas, Grace Wei, Cecilia Noecker, Andrew D Patterson, Suneil K Koliwad, Peter J Turnbaugh
Publikováno v:
eLife, Vol 10 (2021)
East Asians (EAs) experience worse metabolic health outcomes compared to other ethnic groups at lower body mass indices; however, the potential role of the gut microbiota in contributing to these health disparities remains unknown. We conducted a mul
Externí odkaz:
https://doaj.org/article/83d0bc1c7af04b4c88d291ca551b57b2
Autor:
Vayu Maini Rekdal, Paola Nol Bernadino, Michael U Luescher, Sina Kiamehr, Chip Le, Jordan E Bisanz, Peter J Turnbaugh, Elizabeth N Bess, Emily P Balskus
Publikováno v:
eLife, Vol 9 (2020)
Catechol dehydroxylation is a central chemical transformation in the gut microbial metabolism of plant- and host-derived small molecules. However, the molecular basis for this transformation and its distribution among gut microorganisms are poorly un
Externí odkaz:
https://doaj.org/article/020d307ed5f144a9b84d12e60098398c
Publikováno v:
eLife, Vol 7 (2018)
Although the human gut microbiome plays a prominent role in xenobiotic transformation, most of the genes and enzymes responsible for this metabolism are unknown. Recently, we linked the two-gene ‘cardiac glycoside reductase’ (cgr) operon encoded
Externí odkaz:
https://doaj.org/article/35eca181826e4172b985c8e2ed2f2578
Autor:
Gabriel G Perron, Lyle Whyte, Peter J Turnbaugh, Jacqueline Goordial, William P Hanage, Gautam Dantas, Michael M Desai
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0069533 (2015)
Using functional metagenomics to study the resistomes of bacterial communities isolated from different layers of the Canadian high Arctic permafrost, we show that microbial communities harbored diverse resistance mechanisms at least 5,000 years ago.
Externí odkaz:
https://doaj.org/article/a5eaa9009e454752a1813fc793fbbace
Autor:
Than S. Kyaw, Chen Zhang, Moriah Sandy, Kai Trepka, Shenwei Zhang, Luis A. Ramirez Hernandez, Lorenzo Ramirez, Janice J.N. Goh, Kristie Yu, Vincent Dimassa, Elizabeth N. Bess, Jacob G. Brockert, Darren S. Dumlao, Jordan E. Bisanz, Peter J. Turnbaugh
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110122- (2024)
Summary: Drug efflux transporters are a major determinant of drug efficacy and toxicity. A canonical example is P-glycoprotein (P-gp), an efflux transporter that controls the intestinal absorption of diverse compounds. Despite a rich literature on th
Externí odkaz:
https://doaj.org/article/fb71a7d7907c423597107107ee38397e
Autor:
Peter J Turnbaugh, Alain eStintzi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2011)
Externí odkaz:
https://doaj.org/article/3c2668d182b147b48629d03f4c323c63
Autor:
Peter Spanogiannopoulos, Than S. Kyaw, Ben G. H. Guthrie, Patrick H. Bradley, Joyce V. Lee, Jonathan Melamed, Ysabella Noelle Amora Malig, Kathy N. Lam, Daryll Gempis, Moriah Sandy, Wesley Kidder, Erin L. Van Blarigan, Chloe E. Atreya, Alan Venook, Roy R. Gerona, Andrei Goga, Katherine S. Pollard, Peter J. Turnbaugh
Publikováno v:
Nature microbiology, vol 7, iss 10
Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether bacterial drug sensitivity and metabolism is driven by pathways conserved in host cells remains unclear. Here we show that anti-cancer fluoropyrimidine drugs inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27de7576db8271fff42cb6648d9751f7
https://doi.org/10.1038/s41564-022-01226-5
https://doi.org/10.1038/s41564-022-01226-5