Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Peter J Scammells"'
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 11 (2022)
Plasmodium falciparum, the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action are desperately required
Externí odkaz:
https://doaj.org/article/0679868db9304f46bdc0d01432a2d431
Autor:
Alessandro Paiardini, Rebecca S Bamert, Komagal Kannan-Sivaraman, Nyssa Drinkwater, Shailesh N Mistry, Peter J Scammells, Sheena McGowan
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115859 (2015)
Malaria is a parasitic disease that remains a global health burden. The ability of the parasite to rapidly develop resistance to therapeutics drives an urgent need for the delivery of new drugs. The Medicines for Malaria Venture have compounds known
Externí odkaz:
https://doaj.org/article/126ae061875a4773b3d91cd622d4616e
Autor:
Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum an
Externí odkaz:
https://doaj.org/article/2d940180a1bd41efa98e153bebf7c041
Autor:
Scott A. Hollingsworth, Brendan Kelly, Celine Valant, Jordan Arthur Michaelis, Olivia Mastromihalis, Geoff Thompson, A. J. Venkatakrishnan, Samuel Hertig, Peter J. Scammells, Patrick M. Sexton, Christian C. Felder, Arthur Christopoulos, Ron O. Dror
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Allosteric GPCR modulators can achieve exquisite subtype selectivity, but the underlying mechanism is unclear. Using molecular dynamics simulations, the authors here identify a previously undetected dynamic pocket in muscarinic GPCRs that is critical
Externí odkaz:
https://doaj.org/article/a0e90ef319f249dd8f9b3fd6b23a0233
Autor:
Owindeep Deo, Sadia Alvi, Vi Pham, Arthur Christopoulos, David M. Thal, Manuela Jörg, Ben Capuano, Celine Valant, Peter J. Scammells
Publikováno v:
Journal of Medicinal Chemistry. 65:12367-12385
Publikováno v:
Molecules, Vol 26, Iss 13, p 3799 (2021)
(1) Background: Two first-in-class racemic dopamine D1 receptor (D1R) positive allosteric modulator (PAM) chemotypes (1 and 2) were identified from a high-throughput screen. In particular, due to its selectivity for the D1R and reported lack of intri
Externí odkaz:
https://doaj.org/article/e41cae1eb0584987aadc02f3f867426a
Autor:
Jon Kyle Awalt, Anh T.N. Nguyen, Tim J. Fyfe, Bui San Thai, Paul J. White, Arthur Christopoulos, Manuela Jörg, Lauren T. May, Peter J. Scammells
Publikováno v:
Journal of Medicinal Chemistry. 65:9076-9095
Autor:
Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Jeremy Shonberg, Peter J. Scammells, Ben Capuano, Patrick M. Sexton, Steven J. Charlton, Jonathan A. Javitch, Arthur Christopoulos, J. Robert Lane
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Biased agonists act at a receptor to preferentially induce distinct intracellular signalling responses over others. Here the authors show how kinetics of ligand binding and signaling responses greatly influence observed bias profiles, and hence must
Externí odkaz:
https://doaj.org/article/0783ff6940594b04b8cd38d7c0762fb1
Autor:
Philip E. Thompson, Hywel David Williams, Peter J. Scammells, Shadabul Haque, Mitchell P. McInerney, Peng Li, Hassan Benameur, Vincent Jannin, Christopher J.H. Porter, Colin W. Pouton, Leigh Ford
Publikováno v:
Pharmaceutical Research. 38:1125-1137
Successful oral peptide delivery faces two major hurdles: low enzymatic stability in the gastro-intestinal lumen and poor intestinal membrane permeability. While lipid-based formulations (LBF) have the potential to overcome these barriers, effective
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64837c0876829a0b9019d72507ac5aa8
https://doi.org/10.7554/elife.80813.sa2
https://doi.org/10.7554/elife.80813.sa2