Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Peter J Scambler"'
Autor:
Daniyal J Jafree, Dale Moulding, Maria Kolatsi-Joannou, Nuria Perretta Tejedor, Karen L Price, Natalie J Milmoe, Claire L Walsh, Rosa Maria Correra, Paul JD Winyard, Peter C Harris, Christiana Ruhrberg, Simon Walker-Samuel, Paul R Riley, Adrian S Woolf, Peter J Scambler, David A Long
Publikováno v:
eLife, Vol 8 (2019)
Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing kidney, despite their established roles in pathology of the mature organ. We performed three
Externí odkaz:
https://doaj.org/article/19f52d73e1eb45febdf317aa6d8af0b5
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207251 (2018)
The CXCL12-CXCR4 pathway has crucial roles in stem cell homing and maintenance, neuronal guidance, cancer progression, inflammation, remote-conditioning, cell migration and development. Recently, work in chick suggested that signalling via CXCR4 in n
Externí odkaz:
https://doaj.org/article/e3adb7b3aae6457bafc753ac7aef9e92
Autor:
Daniel Dilg, Rasha Noureldin M Saleh, Sarah Elizabeth Lee Phelps, Yoann Rose, Laurent Dupays, Cian Murphy, Timothy Mohun, Robert H Anderson, Peter J Scambler, Ariane L A Chapgier
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161096 (2016)
Chromatin remodelling is essential for cardiac development. Interestingly, the role of histone chaperones has not been investigated in this regard. HIRA is a member of the HUCA (HIRA/UBN1/CABIN1/ASF1a) complex that deposits the variant histone H3.3 o
Externí odkaz:
https://doaj.org/article/9973903c252d401187bab8545450d1c8
Autor:
Thomas A Roberts, Francesca C Norris, Helen Carnaghan, Dawn Savery, Jack A Wells, Bernard Siow, Peter J Scambler, Agostino Pierro, Paolo De Coppi, Simon Eaton, Mark F Lythgoe
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109143 (2014)
Mouse embryo imaging is conventionally carried out on ex vivo embryos excised from the amniotic sac, omitting vital structures and abnormalities external to the body. Here, we present an in amnio MR imaging methodology in which the mouse embryo is re
Externí odkaz:
https://doaj.org/article/82e80e3fb3284a14a1c36b9231e900e0
Autor:
Tian Yu, Linda C Meiners, Katrin Danielsen, Monica TY Wong, Timothy Bowler, Danny Reinberg, Peter J Scambler, Conny MA van Ravenswaaij-Arts, M Albert Basson
Publikováno v:
eLife, Vol 2 (2013)
Mutations in CHD7 are the major cause of CHARGE syndrome, an autosomal dominant disorder with an estimated prevalence of 1/15,000. We have little understanding of the disruptions in the developmental programme that underpin brain defects associated w
Externí odkaz:
https://doaj.org/article/177ff238e4a449628e696d4302b16ad9
Autor:
Jennifer C Fuchs, Fhatarah A Zinnamon, Ruth R Taylor, Sarah Ivins, Peter J Scambler, Andrew Forge, Abigail S Tucker, Jennifer F Linden
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80104 (2013)
22q11.2 Deletion Syndrome (22q11DS) arises from an interstitial chromosomal microdeletion encompassing at least 30 genes. This disorder is one of the most significant known cytogenetic risk factors for schizophrenia, and can also cause heart abnormal
Externí odkaz:
https://doaj.org/article/8ef7ce36745c4cfc89012b86f8309778
Autor:
Yuen Fei Wong, Jeffrey B Kopp, Catherine Roberts, Peter J Scambler, Yoshifusa Abe, Alexandra C Rankin, Neelanjana Dutt, Bruce M Hendry, Qihe Xu
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16770 (2011)
BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors. Although the location, concentration and roles of endogenous retinoic acid in post-natal
Externí odkaz:
https://doaj.org/article/770f8289b0cd4b73992e1fd34d0f1ffc
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e6049 (2009)
Tbx1 is a T-box transcription factor implicated in DiGeorge syndrome. The molecular function of Tbx1 is unclear although it can transactivate reporters with T-box binding elements. We discovered that Tbx1 binds Smad1 and suppresses the Bmp4/Smad1 sig
Externí odkaz:
https://doaj.org/article/4fd81bfa1a8b48f2a564b7a9aade4f0a
Autor:
Athanasia Stathopoulou, Ping Wang, Charlotte Thellier, Robert G Kelly, Deyou Zheng, Peter J Scambler
Publikováno v:
Cardiovascular Research.
Aims Haploinsufficiency of the chromo-domain protein CHD7 underlies most cases of CHARGE syndrome, a multisystem birth defect including congenital heart malformation. Context specific roles for CHD7 in various stem, progenitor, and differentiated cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e51e7c3fdaed2393bd6116d4ccaf3dd
https://doi.org/10.1093/cvr/cvad059
https://doi.org/10.1093/cvr/cvad059
Autor:
Anxiang Cai, Guanyu Ye, Sandrine Placier, Perrine Frère, Brigitte Surin, Sophie Vandermeersch, Raphael Kormann, Yi-Chun Xu-Dubois, Magali Genest, Morgane Lannoy, Christos E. Chadjichristos, Jean-Claude Dussaule, Peter J. Scambler, Christos Chatziantoniou, Amélie Calmont
Publikováno v:
Kidney International
Kidney International, 2022, 101 (4), pp.720-732. ⟨10.1016/j.kint.2021.12.028⟩
Kidney International, 2022, 101 (4), pp.720-732. ⟨10.1016/j.kint.2021.12.028⟩
International audience; To guide the development of therapeutic interventions for acute kidney injury, elucidating the deleterious pathways of this global health problem is highly warranted. Emerging evidence has indicated a pivotal role of endotheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555c456e75fb4e20178edde7c8426356
https://doi.org/10.1016/j.kint.2021.12.028
https://doi.org/10.1016/j.kint.2021.12.028