Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Peter J Newman"'
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135738 (2015)
IgG immune complexes contribute to the etiology and pathogenesis of numerous autoimmune disorders, including heparin-induced thrombocytopenia, systemic lupus erythematosus, rheumatoid- and collagen-induced arthritis, and chronic glomerulonephritis. P
Externí odkaz:
https://doaj.org/article/3d2d7c3aed69436e949d5c0b6101daa2
Autor:
Yongwei Zheng, Tamara Adams, Huiying Zhi, Mei Yu, Renren Wen, Peter J Newman, Demin Wang, Debra K Newman
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119739 (2015)
Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization. PLCs are classified into structurally distinct β, γ, δ, ε, ζ, and η isoforms. There are
Externí odkaz:
https://doaj.org/article/ee6d8127081545fd81da6f3bbe186adc
Autor:
Peter J. Newman, Alyssa J. Moroi
Publikováno v:
J Thromb Haemost
BACKGROUND: Thrombocytopenia leading to life-threatening excessive bleeding can be treated by platelet transfusion. Currently, such treatments are totally dependent on donor-derived platelets. To support future applications in the use of in vitro-der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78ad36e74583c8f2752e6e731047e2f
https://doi.org/10.1111/jth.15546
https://doi.org/10.1111/jth.15546
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective:PECAM-1 (platelet endothelial cell adhesion molecule 1) is a 130 kDa member of the immunoglobulin (Ig) gene superfamily that is expressed on the surfaces of platelets and leukocytes and concentrated at the intercellular junctions of conflue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26da732f4a3ddec84600a24f9a20534f
https://pubmed.ncbi.nlm.nih.gov/34937389
https://pubmed.ncbi.nlm.nih.gov/34937389
Publikováno v:
Journal of Cellular and Molecular Medicine
Despite the recent advancements in transfusion medicine, red blood cell (RBC) alloimmunization remains a challenge for multiparous women and chronically transfused patients. At times, diagnostic laboratories depend on difficult‐to‐procure rare re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa23a71145a524526414fadc106d7fb8
https://doi.org/10.1111/jcmm.16872
https://doi.org/10.1111/jcmm.16872
Publikováno v:
Blood Adv
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder caused by maternal antibodies directed against paternally inherited antigens present on the surface of fetal platelets. The human platelet alloantigen HPA-1a (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0c2588dac25030038683fa26b1a620
https://doi.org/10.1182/bloodadvances.2021004371
https://doi.org/10.1182/bloodadvances.2021004371
Publikováno v:
Blood. 140:2828-2828
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f7fc4f19854f6722bf18a0271d303f5
https://doi.org/10.1182/blood-2022-169883
https://doi.org/10.1182/blood-2022-169883
Autor:
Nicole M. J. Zwifelhofer, D. Woodrow Benson, Ke Yan, Robert A. Niebler, Debra K. Newman, John P. Scott, Alyssa J. Moroi, Pippa Simpson, Eckehard A. D. Stuth, Peter J. Newman, Ronald K. Woods, Rachel S. Bercovitz, Regina Cole
Publikováno v:
Thromb Haemost
Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB). In this study, we examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548488e315be4804875b51d73cd34273
https://doi.org/10.1055/s-0039-1700517
https://doi.org/10.1055/s-0039-1700517
Autor:
Nanyan Zhang, Peter J. Newman
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 13:244-252
The contents of platelet α-granules arrive via a number of pathways; some are synthesized by megakaryocytes (MKs), for example, von Willebrand factor (VWF), whereas others are endocytosed from plasma, for example, fibrinogen (Fgn) and factor V (FV).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5dd77b6c1c652679518ba58835294a5
https://doi.org/10.1002/term.2785
https://doi.org/10.1002/term.2785
Autor:
Peter J. Newman, Aye Myat Myat Thinn, Brian R. Curtis, Bjørn Skogen, Jieqing Zhu, Huiying Zhi, Hartmut Weiler, Maria Therese Ahlen
Publikováno v:
Blood Advances. 2:3001-3011
Antibodies to platelet-specific antigens are responsible for 2 clinically important bleeding disorders: posttransfusion purpura and fetal/neonatal alloimmune thrombocytopenia (FNAIT). The human platelet-specific alloantigen 1a/1b (HPA-1a/1b; also kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e0ecce1839d450d50081aa8f763d361
https://doi.org/10.1182/bloodadvances.2018023341
https://doi.org/10.1182/bloodadvances.2018023341