Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Peter J McKinnon"'
Autor:
Harvey Perez, May F Abdallah, Jose I Chavira, Angelina S Norris, Martin T Egeland, Karen L Vo, Callan L Buechsenschuetz, Valentina Sanghez, Jeannie L Kim, Molly Pind, Kotoka Nakamura, Geoffrey G Hicks, Richard A Gatti, Joaquin Madrenas, Michelina Iacovino, Peter J McKinnon, Paul J Mathews
Publikováno v:
eLife, Vol 10 (2021)
Ataxia Telangiectasia (A-T) and Ataxia with Ocular Apraxia Type 1 (AOA1) are devastating neurological disorders caused by null mutations in the genome stability genes, A-T mutated (ATM) and Aprataxin (APTX), respectively. Our mechanistic understandin
Externí odkaz:
https://doaj.org/article/58f72a12e1074e83ad3fff4ba229dc94
Autor:
Marc Zuckermann, Chen He, Jared Andrews, Aditi Bagchi, Roketa Sloan-Henry, Brandon Bianski, Jia Xie, Yingzhe Wang, Nathaniel Twarog, Arzu Onar-Thomas, Kati J. Ernst, Lei Yang, Yong Li, Xiaoyan Zhu, Jennifer K. Ocasio, Kaitlin M. Budd, James Dalton, Xiaoyu Li, Divyabharathi Chepyala, Junyuan Zhang, Ke Xu, Laura Hover, Jordan T. Roach, Kenneth Chun-Ho Chan, Nina Hofmann, Peter J. McKinnon, Stefan M. Pfister, Anang A. Shelat, Zoran Rankovic, Burgess B. Freeman, Jason Chiang, David T. W. Jones, Christopher L. Tinkle, Suzanne J. Baker
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities. Fusion genes activating the MET receptor tyrosine kinase often occur in infant
Externí odkaz:
https://doaj.org/article/c4e30eaef7d54080a0db2c1628bcebbf
Autor:
Frederique Zindy, Youngsoo Lee, Daisuke Kawauchi, Olivier Ayrault, Leila Ben Merzoug, Yang Li, Peter J McKinnon, Martine F Roussel
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129642 (2015)
Dicer, a ribonuclease III enzyme, is required for the maturation of microRNAs. To assess its role in cerebellar and medulloblastoma development, we genetically deleted Dicer in Nestin-positive neural progenitors and in mice lacking one copy for the S
Externí odkaz:
https://doaj.org/article/617f10245bd64a33b6b06da67d55e63a
Autor:
Abrey J Yeo, Olivier J Becherel, John E Luff, Jason K Cullen, Thidathip Wongsurawat, Piroon Jenjaroenpun, Vladimir A Kuznetsov, Peter J McKinnon, Martin F Lavin
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90219 (2014)
Disruption of the Setx gene, defective in ataxia oculomotor apraxia type 2 (AOA2) leads to the accumulation of DNA/RNA hybrids (R-loops), failure of meiotic recombination and infertility in mice. We report here the presence of R-loops in the testes f
Externí odkaz:
https://doaj.org/article/795d1e476f5a48abafc5e5b7e4872206
Autor:
Paulo M G Rodrigues, Paulius Grigaravicius, Martina Remus, Gabriel R Cavalheiro, Anielle L Gomes, Maurício Rocha-Martins, Lucien Frappart, David Reuss, Peter J McKinnon, Andreas von Deimling, Rodrigo A P Martins, Pierre-Olivier Frappart
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69209 (2013)
Nibrin (NBN or NBS1) and ATM are key factors for DNA Double Strand Break (DSB) signaling and repair. Mutations in NBN or ATM result in Nijmegen Breakage Syndrome and Ataxia telangiectasia. These syndromes share common features such as radiosensitivit
Externí odkaz:
https://doaj.org/article/1f7dacd6af75412a94f5205780fff290
Autor:
Deniz Simsek, Erika Brunet, Sunnie Yan-Wai Wong, Sachin Katyal, Yankun Gao, Peter J McKinnon, Jacqueline Lou, Lei Zhang, James Li, Edward J Rebar, Philip D Gregory, Michael C Holmes, Maria Jasin
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002080 (2011)
Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie chromosomal translocations and other genomic rearrangements in somatic cells. The canonical NHEJ pathway, including DNA ligase IV (Lig4), suppresses genomic instab
Externí odkaz:
https://doaj.org/article/4396a48b6f3a49508178da39b80ec8e7
Autor:
Emma Juuri, Pauli Tikka, Andrii Domanskyi, Ian Corfe, Wataru Morita, Peter J. Mckinnon, Nela Jandova, Anamaria Balic
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Ptch receptors 1 and 2 mediate Hedgehog signaling pivotal for organ development and homeostasis. In contrast to embryonic lethal Ptch1−/− phenotype, Ptch2−/− mice display no effect on gross phenotype. In this brief report, we provide evidence
Externí odkaz:
https://doaj.org/article/b9b419be925b40a99242f290831e568d
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Autor:
Manasi Ratnaparkhe, John K. L. Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T. W. Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M. Downing, Stefan M. Pfister, Marc Zapatka, Peter J. McKinnon, Frederick W. Alt, Peter Lichter, Aurélie Ernst
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chromothripsis and chromoanasynthesis lead to locally clustered rearrangements affecting one or a few chromosomes, but their impact on cancer development and progression is unclear. Here the authors analyse the role of DNA repair factors in brain tum
Externí odkaz:
https://doaj.org/article/8c14a72fa08b47349febd37357e6a636
Autor:
Tomoaki Higo, Atsuhiko T. Naito, Tomokazu Sumida, Masato Shibamoto, Katsuki Okada, Seitaro Nomura, Akito Nakagawa, Toshihiro Yamaguchi, Taku Sakai, Akihito Hashimoto, Yuki Kuramoto, Masamichi Ito, Shungo Hikoso, Hiroshi Akazawa, Jong-Kook Lee, Ichiro Shiojima, Peter J. McKinnon, Yasushi Sakata, Issei Komuro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes
Externí odkaz:
https://doaj.org/article/f167f426b5044f03bde4b9f896135c5c
Autor:
Shan Zha, Tanya T. Paull, Peter J. Mckinnon, Dong Wang, Verna M. Estes, Jun Xu, Brian J. Lee, Yang Li, Kenta Yamamoto, Ji-Hoon Lee, Demis Menolfi, Lisa M. Houghton, Maja Milanovic
ATM kinase is a tumor suppressor and a master regulator of the DNA damage response. Most cancer-associated alterations to ATM are missense mutations at the PI3-kinase regulatory domain (PRD) or the kinase domain. Expression of kinase-dead (KD) ATM pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b98792ddd4a9e236a02544fe4fa800a
https://doi.org/10.1158/0008-5472.c.6512610.v1
https://doi.org/10.1158/0008-5472.c.6512610.v1