Biocatalytic route scouting and enzyme screening toward the synthesis of α-benzyl L-glutamate

Autor: Peter J. L. M. Quaedflieg, Lisanne M. H. Jente, Monika Müller, Linda Vermote, Victor Plesciuc, Jan-Metske van der Laan, Lone Nielsen, Martin Schürmann

Publikováno v: Frontiers in Catalysis, Vol 3 (2024)

We here report four biocatalytic approaches for the synthesis of the protected amino acid building block α-benzyl L-glutamate. Screenings of these routes to identify active and selective enzymes were conducted, and major hits were confirmed in retes

Externí odkaz: https://doaj.org/article/605dc3b86fdd4a58ae610ba01a76b780

Bio-based synthesis of cyclopentane-1,3-diamine and its application in bifunctional monomers for poly-condensation

Autor: Darya Hadavi, Jurrie Noordijk, Gerard K. M. Verzijl, Siri Mogensen, Peter J. L. M. Quaedflieg, Peiliang Han, Paul L. Alsters, Luciano G. Monsegue, Stefaan M. A. De Wildeman, Christian A. M. R. van Slagmaat

Publikováno v: Green Chemistry, 23(18), 7100-7114. Royal Society of Chemistry

A novel and green route for the synthesis of cyclopentane-1,3-diamine (CPDA) from hemicellulosic feed-stock is established in this work. Through many explorations and optimizations, the single successful multi-step synthesis was found to comprise: (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da24affe8276f1a4c4086c35eb63586
https://doi.org/10.1039/d1gc02372a

Chemoselective formation of cyclo-aliphatic and cyclo-olefinic 1,3-diols via pressure hydrogenation of potentially biobased platform molecules using Knölker-type catalysts

Autor: Darya Hadavi, Christian A. M. R. van Slagmaat, Khi Chhay Chou, Alfonso J. Schwalb Freire, Stefaan M. A. De Wildeman, Paul L. Alsters, Peiliang Han, Gerard K. M. Verzijl, Teresa Faber, Peter J. L. M. Quaedflieg

Publikováno v: Dalton Transactions, 50(29), 10102-10112. Royal Society of Chemistry

The hydrogenative conversions of the biobased platform molecules 4-hydroxycyclopent-2-enone and cyclopentane-1,3-dione to their corresponding 1,3-diols are established using a pre-activated Knolker-type iron catalyst. The catalyst exhibits a high sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7925c73e4dcd0911b1a502b70d9f1cde
https://doi.org/10.1039/d1dt01252e

Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1

Autor: Ana Toplak, Peter J. L. M. Quaedflieg, Hein J. Wijma, Dick B. Janssen, Henriëtte J. Rozeboom, Marcel Schmidt, Timo Nuijens, Jan H. van Maarseveen

Publikováno v: Organic & Biomolecular Chemistry, 16(4), 609-618. ROYAL SOC CHEMISTRY
Organic & Biomolecular Chemistry, 16(4), 609-618. Royal Society of Chemistry

The synthesis of thymosin-α1, an acetylated 28 amino acid long therapeutic peptide, via conventional chemical methods is exceptionally challenging. The enzymatic coupling of unprotected peptide segments in water offers great potential for a more eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7930220d303de245ff7b2612569606e
https://doi.org/10.1039/c7ob02812a

Omniligase-1

Autor: Peter J. L. M. Quaedflieg, Tilman M. Hackeng, Ana Toplak, Marcel Schmidt, Timo Nuijens, Jan H. van Maarseveen, Gaston J. J. Richelle, Hans Ippel

Publikováno v: Advanced Synthesis & Catalysis, 359(12), 2050-2055. Wiley-VCH Verlag

Strategies for the efficient synthesis of peptide macrocycles have been a long-standing goal. In this paper, we demonstrate the use of the peptide ligase termed omniligase-1 as a versatile and broadly applicable enzymatic tool for peptide cyclization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e1346bba7c6c52bf694727f4032f0c
https://doi.org/10.1002/adsc.201700314