Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Peter J Huwe"'
Autor:
Paul Y Kim, Audrey Y Kim, Jamie J Newman, Eleonora Cella, Thomas C Bishop, Peter J Huwe, Olga N Uchakina, Robert J McKallip, Vance L Mack, Marnie P Hill, Ifedayo Victor Ogungbe, Olawale Adeyinka, Samuel Jones, Gregory Ware, Jennifer Carroll, Jarrod F Sawyer, Kenneth H Densmore, Michael Foster, Lescia Valmond, John Thomas, Taj Azarian, Krista Queen, Jeremy P Kamil
Publikováno v:
PLOS Global Public Health, Vol 3, Iss 7, p e0001935 (2023)
The lack of routine viral genomic surveillance delayed the initial detection of SARS-CoV-2, allowing the virus to spread unfettered at the outset of the U.S. epidemic. Over subsequent months, poor surveillance enabled variants to emerge unnoticed. Ag
Externí odkaz:
https://doaj.org/article/cfc3ae84ac184d048187f70809359a05
Autor:
Paul Y. Kim, Audrey Y. Kim, Jamie J. Newman, Eleonora Cella, Thomas C. Bishop, Peter J. Huwe, Olga N. Uchakina, Robert J. McKallip, Vance L. Mack, Marnie P. Hill, Ifedayo Victor Ogungbe, Olawale Adeyinka, Samuel Jones, Gregory Ware, Jennifer Carroll, Jarrod F. Sawyer, Kenneth H. Densmore, Michael Foster, Lescia Valmond, John Thomas, Taj Azarian, Krista Queen, Jeremy P. Kamil
The lack of routine viral genomic surveillance delayed the initial detection of SARS-CoV-2, allowing the virus to spread unfettered at the outset of the U.S. epidemic. Over subsequent months, poor surveillance enabled variants to emerge unnoticed. Ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4a6723f6817aabde5104a0407765fe
https://doi.org/10.1101/2022.10.19.512816
https://doi.org/10.1101/2022.10.19.512816
Autor:
Rahmat K. Sikder, Randy W. Lesh, Peter J. Huwe, Sanjeevani Arora, Sanat Deshpande, Michael J. Hall, Amanda J. Browne, Erica A. Golemis, Roland L. Dunbrack, Manali Shah, Emmanuelle Nicolas
Publikováno v:
Cancer Biology & Therapy. 18:519-533
The cancer-predisposing Lynch Syndrome (LS) arises from germline mutations in DNA mismatch repair (MMR) genes, predominantly MLH1, MSH2, MSH6, and PMS2. A major challenge for clinical diagnosis of LS is the frequent identification of variants of unce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a5d186fcbecf69de4498ff13d75715
https://doi.org/10.1080/15384047.2017.1326439
https://doi.org/10.1080/15384047.2017.1326439
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:370-391
In CASP11, the organizers sought to bring the biological inferences from predicted structures to the fore. To accomplish this, we assessed the models for their ability to perform quantifiable tasks related to biological function. First, for 10 target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0a35125f4c5bdba4223d2b586285e6f
https://doi.org/10.1002/prot.24997
https://doi.org/10.1002/prot.24997
Autor:
Daniel J. Crawford, Charlie Y. Mo, Kiran S. Gajula, Rahul M. Kohli, James T. Stivers, Peter J. Huwe, Ravi Radhakrishnan
Publikováno v:
Nucleic Acids Research
Antibody maturation is a critical immune process governed by the enzyme activation-induced deaminase (AID), a member of the AID/APOBEC DNA deaminase family. AID/APOBEC deaminases preferentially target cytosine within distinct preferred sequence motif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc16f30c7dc0baba65ea305cd550faa0
https://pubmed.ncbi.nlm.nih.gov/25064858
https://pubmed.ncbi.nlm.nih.gov/25064858
Molecular dynamics calculations have been used to determine the structure of phosphatidylinositol 4,5 bisphosphate (PIP2) at the quantum level and to quantify the propensity for PIP2 to bind two physiologically relevant divalent cations, Mg(2+) and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b53debce6d725f2ddbd1147e8bd1bb
https://europepmc.org/articles/PMC3930568/
https://europepmc.org/articles/PMC3930568/
Autor:
Sanat Deshpande, Manali Shah, Sanjeevani Arora, Michael J. Hall, Peter J. Huwe, Erica A. Golemis, Rahmat K. Sikder, Roland L. Dunbrack
Publikováno v:
Cancer Research. 76:5286-5286
Lynch syndrome (LS) highly predisposes individuals and their families to an increased risk of colorectal cancers and to cancers of the endometrium, ovary, gastrointestinal tract, pancreas, upper urinary tract, and other tissues. The occurrence of LS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcd592f45aea49b378ff952a4feccc0e
https://doi.org/10.1158/1538-7445.am2016-5286
https://doi.org/10.1158/1538-7445.am2016-5286
Publikováno v:
Biophysical Journal. 104:79a
Molecular dynamics calculations have been used to determine the structure of phosphatidylinositol 4,5 bisphosphate (PIP2) at the quantum level and to quantify the propensity for PIP2 to bind two physiologically relevant divalent cations, Mg2+ and Ca2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcb080944ee5acc3bd4eebb9460630d
https://doi.org/10.1016/j.bpj.2012.11.474
https://doi.org/10.1016/j.bpj.2012.11.474
Publikováno v:
Biophysical Journal. 104:662a
Activating mutations in the kinase domain of anaplastic lymphoma kinase (ALK) have been implicated in the early childhood cancer, neuroblastoma. using molecular dynamics based methods, we investigate how these point mutations promote constitutive kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c131d534c495f67d21dcaa8d57dc45f
https://doi.org/10.1016/j.bpj.2012.11.3654
https://doi.org/10.1016/j.bpj.2012.11.3654
Autor:
Kateryna Krytska, Scott C. Bresler, Patrick McGrady, Daniel A. Weiser, Marci Laudenslager, Yael P. Mosse, Michael D. Hogarty, Hannah T. Ryles, Eric F. Rappaport, Jin H. Park, Mark A. Lemmon, Ravi Radhakrishnan, Wendy B. London, Peter J. Huwe, Andrew Wood
Publikováno v:
Cancer Cell. (5):682-694
Genetic studies have established anaplastic lymphoma kinase (ALK), a cell surface receptor tyrosine kinase, as a tractable molecular target in neuroblastoma. We describe comprehensive genomic, biochemical, and computational analyses of ALK mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4d3986f2659d9947efefb260861e4b