Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Peter J H, Webborn"'
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009384 (2021)
It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billi
Externí odkaz:
https://doaj.org/article/1c007e1d50c645f39fc22e11900307c2
Autor:
Peter J. H. Webborn, Stefan Kavanagh, Andrew Cassidy, Paul M. O'Neill, Rachel H. Clare, Mark J. Taylor, Mark C. Wenlock, Neil G. Berry, W. David Hong, Darren A. N. Cook, Gemma L. Nixon, Stephen A. Ward, Paul McGillan, Suet C. Leung, Kelly L. Johnston, Louise Ford
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
Autor:
Paul, McGillan, Neil G, Berry, Gemma L, Nixon, Suet C, Leung, Peter J H, Webborn, Mark C, Wenlock, Stefan, Kavanagh, Andrew, Cassidy, Rachel H, Clare, Darren A, Cook, Kelly L, Johnston, Louise, Ford, Stephen A, Ward, Mark J, Taylor, W David, Hong, Paul M, O'Neill
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Autor:
Paul M. O'Neill, Edward W. Tate, W. David Hong, Adam P. Roberts, Marc P. Hübner, Peter J. H. Webborn, Mark J. Taylor, Alexandra Ehrens, Stefan J. Frohberger, Dominique Struever, John Archer, Farid Benayoud, Joseph D. Turner, Rachel H. Clare, Achim Hoerauf, Stefan Kavanagh, Fabian Gusovsky, Andrew Steven, Neil G. Berry, Kelly L. Johnston, Ghaith Aljayyoussi, Andrew Cassidy, Remigiusz A. Serwa, Suet C. Leung, Janet Hemingway, Alasdair T. M. Hubbard, Gemma L. Nixon, Amy Siu, Stephen A. Ward, Emma A Murphy, Louise Ford, Li Qie, Motohiro Shiotani, Darren A. N. Cook
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d971c5d526af7ac9de5fb24d20f2893d
Autor:
W David, Hong, Farid, Benayoud, Gemma L, Nixon, Louise, Ford, Kelly L, Johnston, Rachel H, Clare, Andrew, Cassidy, Darren A N, Cook, Amy, Siu, Motohiro, Shiotani, Peter J H, Webborn, Stefan, Kavanagh, Ghaith, Aljayyoussi, Emma, Murphy, Andrew, Steven, John, Archer, Dominique, Struever, Stefan J, Frohberger, Alexandra, Ehrens, Marc P, Hübner, Achim, Hoerauf, Adam P, Roberts, Alasdair T M, Hubbard, Edward W, Tate, Remigiusz A, Serwa, Suet C, Leung, Li, Qie, Neil G, Berry, Fabian, Gusovsky, Janet, Hemingway, Joseph D, Turner, Mark J, Taylor, Stephen A, Ward, Paul M, O'Neill
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) are neglected tropical diseases that cause severe disability and affect more than 157 million people globally. Current control efforts are hindered by the lack of
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009384 (2021)
PLoS Pathogens
PLoS Pathogens
It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billi
Autor:
Elizabeth Kinchin, Lilian Alcaraz, Aaron Rigby, Haydn Beaton, Matt Soars, Rebecca Denton, Keith Bowers, Ash Bahl, David Donald, John Collington, Cathy MacDonald, Rob Riley, Peter J. H. Webborn, Christopher A. Luckhurst, Brian Springthorpe, Mark Furber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7702-7706
The discovery of potent small molecule dual antagonists of the human CCR3 and H(1) receptors is described for the treatment of allergic diseases, for example, asthma and allergic rhinitis. Optimizing in vitro potency and metabolic stability, starting
Autor:
Aaron Rigby, Peter J. H. Webborn, Rob Riley, John Collington, Mark Furber, Brian Springthorpe, Matt Soars, Ash Bahl, Cathy MacDonald, Keith Bowers, Elizabeth Kinchin, Lilian Alcaraz, Rebecca Denton, Haydn Beaton, David Donald, Christopher A. Luckhurst
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7707-7710
The second part of this communication focuses on the resolution of issues surrounding the series of hydroxyamide phenoxypiperidine CCR3/H(1) dual antagonists described in Part I. This involved further structural exploration directed at reducing metab
Autor:
Peter J. H. Webborn, Malcolm R. Clench, Nicole Strittmatter, John G. Swales, James W. Tucker, Richard J. A. Goodwin
Publikováno v:
Scientific Reports
Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing robust and reliable qualitative distribution images of an analyte or analytes in tissue sectio
Autor:
Paul Lyne, Patrick Brassil, Ann White, Jason Breed, Mei Su, Dorin Toader, Yan Yu, Sonya Zabludoff, Jon Read, James W. Janetka, Chun Deng, Dingwei Yu, Vibha Oza, Susan Ashwell, Zheng Xiaolan, Nicholas John Newcombe, Candice Horn, Martin Pass, Peter J. H. Webborn, Ludo Otterbien, Heather Haye, Jay Ezhuthachan, Anna L Valentine, Sian Roswell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5133-5138
Checkpoint Kinase-1 (Chk1, CHK1, CHEK1) is a Ser/Thr protein kinase that mediates cellular responses to DNA-damage. A novel class of Chk1 inhibitors, triazoloquinolones/triazolones (TZ's) was identified by high throughput screening. The optimization