Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Peter J Gough"'
Autor:
Jong W Yu, Sandy Hoffman, Allison M Beal, Angela Dykon, Michael A Ringenberg, Anna C Hughes, Lauren Dare, Amber D Anderson, Joshua Finger, Viera Kasparcova, David Rickard, Scott B Berger, Joshi Ramanjulu, John G Emery, Peter J Gough, John Bertin, Kevin P Foley
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127083 (2015)
CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and other pathways. Previous studies have suggested that as part of this complex, MALT1 functions as both a scaffolding protein to activate NF-κB through recruitment o
Externí odkaz:
https://doaj.org/article/327f71770e43439cbfdc0ac0b47f3d3d
Autor:
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Pamela A Haile, Xin Zeng, Monica N Montoute, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, John G Emery, Robert W Marquis, Peter J Gough, John Bertin
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96737 (2014)
NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a
Externí odkaz:
https://doaj.org/article/d8966b29a270430a972aa590bfa33f4f
Autor:
Daniel M Reed, Gabor Foldes, Timothy Gatheral, Koralia E Paschalaki, Zsuzsanna Lendvai, Zsolt Bagyura, Tamas Nemeth, Judit Skopal, Bela Merkely, Aurica G Telcian, Leila Gogsadze, Michael R Edwards, Peter J Gough, John Bertin, Sebastian L Johnston, Sian E Harding, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e91119 (2014)
Human embryonic stem cell-derived endothelial cells (hESC-EC), as well as other stem cell derived endothelial cells, have a range of applications in cardiovascular research and disease treatment. Endothelial cells sense Gram-negative bacteria via the
Externí odkaz:
https://doaj.org/article/241a3f71d5eb429f83104ac2d430c14d
Autor:
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Xin Zeng, Monica N Montoute, Tushar Chordia, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, Pamela A Haile, Jong Yu, John G Emery, Robert W Marquis, Peter J Gough, John Bertin
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69619 (2013)
NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the
Externí odkaz:
https://doaj.org/article/5e593a2a329d48da9774642aa0357266
A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses.
Autor:
Timothy Gatheral, Daniel M Reed, Laura Moreno, Peter J Gough, Bart J Votta, Clark A Sehon, David J Rickard, John Bertin, Eric Lim, Andrew G Nicholson, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42386 (2012)
Understanding the mechanisms by which pathogens induce vascular inflammation and dysfunction may reveal novel therapeutic targets in sepsis and related conditions. The intracellular receptor NOD1 recognises peptidoglycan which features in the cell wa
Externí odkaz:
https://doaj.org/article/5d1c7be4724b464285ac6ff607299987
Autor:
Yulin Ouyang, Li Wen, Jane A. Armstrong, Michael Chvanov, Diane Latawiec, Wenhao Cai, Mohammad Awais, Rajarshi Mukherjee, Wei Huang, Peter J. Gough, John Bertin, Alexei V. Tepikin, Robert Sutton, David N. Criddle
Publikováno v:
Cells, Vol 10, Iss 5, p 1035 (2021)
Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy. The role of Receptor-Interacting Protein Kinase 1 (RIPK1), a key component of programmed necrosis
Externí odkaz:
https://doaj.org/article/657597a70d3a47e68edf551bae6591c1
Autor:
Yves Dondelinger, Gunter Hartel, Mark L. Everard, John Bertin, Vivian Zhang, John W. Upham, Peter J. Gough, Natasha Collinson, Antoon J. M. van Oosterhout, Rhiannon B. Werder, Mathieu J.M. Bertrand, Jennifer Simpson, Ashik Ullah, Zhixuan Loh, Kirsten Spann, Simon Phipps, Christopher C Blyth, Jason P. Lynch
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Rationale: Respiratory syncytial virus (RSV) bronchiolitis causes significant infant mortality. Bronchiolitis is characterized by airway epithelial cell (AEC) death; however, the mode of death remains unknown. Objectives: To determine whether necropt
Autor:
Linda M. McAllister-Lucas, Tina L. Sumpter, Kevin Foley, Danielle N. Alfano, Peter J. Gough, John Bertin, Peter C. Lucas, Linda R. Klei, Matthew Trotta, Hanna B. Klei
Publikováno v:
The Journal of Immunology. 204:2337-2348
The signaling protein MALT1 plays a key role in promoting NF-κB activation in Ag-stimulated lymphocytes. In this capacity, MALT1 has two functions, acting as a scaffolding protein and as a substrate-specific protease. MALT1 is also required for NF-
Autor:
Mohammad Awais, Wei Huang, Wenhao Cai, John Bertin, Alexei V. Tepikin, Li Wen, Jane A Armstrong, Michael Chvanov, David N. Criddle, Rajarshi Mukherjee, Robert Sutton, Peter J. Gough, Diane Latawiec, Yulin Ouyang
Publikováno v:
CELLS
Cells
Cells, Vol 10, Iss 1035, p 1035 (2021)
Volume 10
Issue 5
Cells
Cells, Vol 10, Iss 1035, p 1035 (2021)
Volume 10
Issue 5
Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy. The role of Receptor-Interacting Protein Kinase 1 (RIPK1), a key component of programmed necrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc0219b10329fb521ac7200948cf421
Autor:
Pamela A. Haile, Linda N. Casillas, Bartholomew J. Votta, Gren Z. Wang, Adam K. Charnley, Xiaoyang Dong, Michael J. Bury, Joseph J. Romano, John F. Mehlmann, Bryan W. King, Karl F. Erhard, Charles R. Hanning, David B. Lipshutz, Biva M. Desai, Carol A. Capriotti, Michelle C. Schaeffer, Scott B. Berger, Mukesh K. Mahajan, Michael A. Reilly, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, John K. Kenna, Allison M. Beal, Michael T. Ouellette, Mike Kelly, Gillian Stemp, Máire A. Convery, Anna Vossenkämper, Thomas T. MacDonald, Peter J. Gough, John Bertin, Robert W. Marquis
Publikováno v:
Journal of Medicinal Chemistry. 62:6482-6494