Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Peter J Cullen"'
Autor:
Boris Simonetti, Qian Guo, Manuel Giménez-Andrés, Kai-En Chen, Edmund R R Moody, Ashley J Evans, Mintu Chandra, Chris M Danson, Tom A Williams, Brett M Collins, Peter J Cullen
Publikováno v:
PLoS Biology, Vol 20, Iss 4, p e3001601 (2022)
Coat complexes coordinate cargo recognition through cargo adaptors with biogenesis of transport carriers during integral membrane protein trafficking. Here, we combine biochemical, structural, and cellular analyses to establish the mechanistic basis
Externí odkaz:
https://doaj.org/article/844881cd71af4ba98857830ac0cd310b
Autor:
Kirsty J McMillan, Paul J Banks, Francesca LN Hellel, Ruth E Carmichael, Thomas Clairfeuille, Ashley J Evans, Kate J Heesom, Philip Lewis, Brett M Collins, Zafar I Bashir, Jeremy M Henley, Kevin A Wilkinson, Peter J Cullen
Publikováno v:
eLife, Vol 10 (2021)
The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To provide a broader view of SNX27-associated pathologies,
Externí odkaz:
https://doaj.org/article/37f2888d4612454586ef6c3bee532043
Autor:
Michael D Healy, Manuela K Hospenthal, Ryan J Hall, Mintu Chandra, Molly Chilton, Vikas Tillu, Kai-En Chen, Dion J Celligoi, Fiona J McDonald, Peter J Cullen, J Shaun Lott, Brett M Collins, Rajesh Ghai
Publikováno v:
eLife, Vol 7 (2018)
The COMMD proteins are a conserved family of proteins with central roles in intracellular membrane trafficking and transcription. They form oligomeric complexes with each other and act as components of a larger assembly called the CCC complex, which
Externí odkaz:
https://doaj.org/article/52ef44e3fdd642e78e446da5ae0c2ac6
Autor:
Rebeka Butkovič, Alexander P. Walker, Michael D. Healy, Kerrie E. McNally, Meihan Liu, Tineke Veenendaal, Kohji Kato, Nalan Liv, Judith Klumperman, Brett M. Collins, Peter J. Cullen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Commander is a multiprotein complex that orchestrates endosomal recycling of integral cargo proteins and is essential for normal development. While the structure of this complex has recently been described, how cargo proteins are selected fo
Externí odkaz:
https://doaj.org/article/85deafa608c9468da12e9b3d0fe09ce1
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32386 (2012)
The inositol (1,4,5) trisphosphate 3-kinases comprise a family of enzymes (A, B, and C) that phosphorylate the calcium mobilising molecule inositol (1,4,5) trisphosphate (IP(3)) to generate inositol (1,3,4,5) tetrakisphosphate. This molecule can func
Externí odkaz:
https://doaj.org/article/9f0c330a81d847d09e083e7e5b943ac9
Autor:
Alessia Calcagni’, Leopoldo Staiano, Nicolina Zampelli, Nadia Minopoli, Niculin J. Herz, Giuseppe Di Tullio, Tuong Huynh, Jlenia Monfregola, Alessandra Esposito, Carmine Cirillo, Aleksandar Bajic, Mahla Zahabiyon, Rachel Curnock, Elena Polishchuk, Luke Parkitny, Diego Luis Medina, Nunzia Pastore, Peter J. Cullen, Giancarlo Parenti, Maria Antonietta De Matteis, Paolo Grumati, Andrea Ballabio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Batten disease, one of the most devastating types of neurodegenerative lysosomal storage disorders, is caused by mutations in CLN3. Here, we show that CLN3 is a vesicular trafficking hub connecting the Golgi and lysosome compartments. Proteo
Externí odkaz:
https://doaj.org/article/6b4c5ef6c8024f6aa64e8fc752ca2920
Autor:
James L. Daly, Chris M. Danson, Philip A. Lewis, Lu Zhao, Sara Riccardo, Lucio Di Filippo, Davide Cacchiarelli, Daehoon Lee, Stephen J. Cross, Kate J. Heesom, Wen-Cheng Xiong, Andrea Ballabio, James R. Edgar, Peter J. Cullen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer dysfunction, which is linked to neurodegenerative disorders inclu
Externí odkaz:
https://doaj.org/article/25c4f4af8ff64ff395880ff48cfb4aa6
Autor:
Jiahe Lu, Alisa Veler, Boris Simonetti, Timsse Raj, Po Han Chou, Stephen J. Cross, Alexander M. Phillips, Xiongtao Ruan, Lan Huynh, Andrew W. Dowsey, Dingwei Ye, Robert F. Murphy, Paul Verkade, Peter J. Cullen, Christoph Wülfing
Publikováno v:
Cells, Vol 12, Iss 21, p 2558 (2023)
T cells can express multiple inhibitory receptors. Upon induction of T cell exhaustion in response to a persistent antigen, prominently in the anti-tumor immune response, many are expressed simultaneously. Key inhibitory receptors are CTLA-4, PD-1, L
Externí odkaz:
https://doaj.org/article/ac243134714943f4b979a7673d47dd5c
Publikováno v:
Traffic. 24:234-250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f494c8791eec8b03d84b618efc5e93d5
https://doi.org/10.1111/tra.12885
https://doi.org/10.1111/tra.12885
The OECD Convention is the first major international treaty specifically to address'supply-side bribery'by sanctioning the briber. The OECD Convention establishes an international standard for compliance with anti-corruption rules by 36 countries, in
