Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Peter J Choi"'
Autor:
Elizabeth Cooper, Caitlin R. M. Oyagawa, Rebecca Johnson, Peter J. Choi, Jena Macapagal Foliaki, Jason Correia, Patrick Schweder, Peter Heppner, Edward Mee, Clinton Turner, Richard Faull, William A. Denny, Mike Dragunow, Jiney Jose, Thomas I-H. Park
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Glioblastoma is the most common and aggressive primary brain tumour in adults. The development of anti-brain cancer agents are challenged by the blood-brain barrier and the resistance conferred by the local tumour microenvironment. Heptameth
Externí odkaz:
https://doaj.org/article/e89e926fe6974ecaa78c8ebfb63ce277
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100343- (2022)
The use of heptamethine cyanine dyes (HMCD) as a vehicle for targeted delivery of drugs to cancer tissues shows promise. The synthesis of drug–dye conjugates is hampered by scalability and purification issues. Herein we disclose synthetic procedure
Externí odkaz:
https://doaj.org/article/6867163edde540debaccaa9bf1556810
Autor:
Hamish S. Sutherland, Peter J. Choi, Guo-Liang Lu, Anna C. Giddens, Amy S. T. Tong, Scott G. Franzblau, Christopher B. Cooper, Brian D. Palmer, William A. Denny
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1125 (2022)
Pyrazolo[1,5-a]pyrimidines have been reported as potent inhibitors of mycobacterial ATP synthase for the treatment of Mycobacterium tuberculosis (M.tb). In this work, we report the design and synthesis of approximately 70 novel 3,5-diphenyl-N-(pyridi
Externí odkaz:
https://doaj.org/article/4840706fc3a44c07b8ab3fa39c285356
Autor:
Elizabeth Cooper, Peter J. Choi, William A. Denny, Jiney Jose, Mike Dragunow, Thomas I.-H. Park
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier (BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by the local tumor microenvironment. Clinically approved chemotherapeut
Externí odkaz:
https://doaj.org/article/f16ec4db14f14da6996120a8e137954f
Autor:
Peter J. Choi, Daniel Conole, Hamish S. Sutherland, Adrian Blaser, Amy S.T. Tong, Christopher B. Cooper, Anna M. Upton, Brian D. Palmer, William A. Denny
Publikováno v:
Molecules, Vol 25, Iss 6, p 1423 (2020)
Bedaquiline is a novel drug approved in 2012 by the FDA for treatment of drug-resistant tuberculosis (TB). Although it shows high efficacy towards drug-resistant forms of TB, its use has been limited by the potential for significant side effects. In
Externí odkaz:
https://doaj.org/article/2c871cfcedf94323adc59bd51b4d499c
Autor:
Elizabeth Cooper, Zoe Woolf, Molly E V Swanson, Jason Correia, Patrick Schweder, Edward Mee, Peter Heppner, Clinton Turner, Richard L M Faull, Emma L Scotter, William A Denny, Peter J Choi, Mike Dragunow, Jiney Jose, Thomas I-H Park
Publikováno v:
Neuro-oncology advances. 4(1)
Background Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Whilst the role of the efflux transporters are well established in GBM, the expression and function of uptake transporters, such as the organic anion trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ba4f12f6c5b1784b74ce1ee4dba602
https://pubmed.ncbi.nlm.nih.gov/36382105
https://pubmed.ncbi.nlm.nih.gov/36382105
Autor:
Elizabeth Cooper, Peter J. Choi, Kihwan Hwang, Kyung M. Nam, Chae‐Yong Kim, Tina Shaban, Patrick Schweder, Edward Mee, Jason Correia, Clinton Turner, Richard L. M. Faull, William A. Denny, Katsuya Noguchi, Mike Dragunow, Jiney Jose, Thomas I.‐H. Park
Publikováno v:
Chemical biologydrug designREFERENCES.
The development of chemotherapies for glioblastoma is hindered by their limited bioavailability and toxicity on normal brain function. To overcome these limitations, we investigated the structure-dependent activity of heptamethine cyanine dyes (HMCD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b9812c550b917d6fe592d96f78ba8f
https://pubmed.ncbi.nlm.nih.gov/36323652
https://pubmed.ncbi.nlm.nih.gov/36323652
Autor:
Elizabeth Alexandra Cooper, Peter J Choi, Kyung Mi Nam, Patrick Schweder, Edward Mee, Clinton Turner, Richard Faull, William A. Denny, Chae-Yong Kim, Mike Dragunow, Kihwan Hwang, Jiney Jose, Thomas I-H Park
Publikováno v:
WFNOS 2022 Abstract Book.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb686680e61a407e59aaa90d8cb11d77
https://doi.org/10.14791/btrt.2022.10.f-1232
https://doi.org/10.14791/btrt.2022.10.f-1232
Autor:
Anna Cullen, Elizabeth Cooper, William A Denny, Mike Dragunow, Peter J Choi, Thomas I-H Park, Jiney Jose
Publikováno v:
WFNOS 2022 Abstract Book.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87d036eb528e850fb5592729e50e0f2
https://doi.org/10.14791/btrt.2022.10.f-1292
https://doi.org/10.14791/btrt.2022.10.f-1292
Autor:
Clinton Turner, Peter J. Choi, Thomas I. H. Park, Jiney Jose, Richard L.M. Faull, William A. Denny, Edward W. Mee, Patrick Schweder, Elizabeth Cooper, Mike Dragunow
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
Cytoprotective agents are mainly used to protect the gastrointestinal tract linings and in the treatment of gastric ulcers. These agents are devoid of appreciable cytotoxic or cytostatic effects, and medicinal chemistry efforts to modify them into an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e7d1954e3fb475af9112776a26c57f
https://pubmed.ncbi.nlm.nih.gov/34438012
https://pubmed.ncbi.nlm.nih.gov/34438012