Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Peter J Blair"'
Autor:
Moon Young Lee, Chanjae Park, Se Eun Ha, Paul J Park, Robyn M Berent, Brian G Jorgensen, Robert D Corrigan, Nathan Grainger, Peter J Blair, Orazio J Slivano, Joseph M Miano, Sean M Ward, Terence K Smith, Kenton M Sanders, Seungil Ro
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171262 (2017)
Serum response factor (SRF) transcriptionally regulates expression of contractile genes in smooth muscle cells (SMC). Lack or decrease of SRF is directly linked to a phenotypic change of SMC, leading to hypomotility of smooth muscle in the gastrointe
Externí odkaz:
https://doaj.org/article/e61d17fcddeb42c798c6f15cef0042fa
Autor:
Kenton M. Sanders, Matthew C. Shonnard, Lauren E. Peri, Sung Jin Hwang, Peter J. Blair, Yulia Bayguinov, Sean M. Ward
Publikováno v:
Diabetes
Patients with diabetes often develop gastrointestinal motor problems, including gastroparesis. Previous studies have suggested this gastric motor disorder was a consequence of an enteric neuropathy. Disruptions in interstitial cells of Cajal (ICC) ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6164f84fd4ab223f49a2cce25fb052f1
http://europepmc.org/articles/PMC6385756
http://europepmc.org/articles/PMC6385756
Autor:
Kenton M. Sanders, Sean M. Ward, Lauen E. Peri, David M. Pardo, Yulia Bayguinov, Timothy I. Webb, Peter J. Blair, Tae Sik Sung, Sang Don Koh, Jason R. Rock, Sung Jin Hwang
Publikováno v:
The Journal of Physiology. 596:1549-1574
KEY POINTS Enteric neurotransmission is essential for gastrointestinal (GI) motility, although the cells and conductances responsible for post-junctional responses are controversial. The calcium-activated chloride conductance (CaCC), anoctamin-1 (Ano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::412903829b1fb145b6000c68113ae20e
https://doi.org/10.1113/jp275478
https://doi.org/10.1113/jp275478
Autor:
Rachael Fortune-Grant, Haifeng Zheng, Yulia Bayguinov, Matthew C. Shonnard, Nathan Grainger, Jason R. Rock, Sean M. Ward, Sung Jin Hwang, Grant W. Hennig, Lauren E. Peri, David M. Pardo, Kenton M. Sanders, Sonali Deep Verma, Peter J. Blair, Robert S. Cook
Publikováno v:
J Physiol
KEY POINTS: Electrical pacemaking in gastrointestinal muscles is generated by specialized interstitial cells of Cajal that produce the patterns of contractions required for peristalsis and segmentation in the gut. The calcium‐activated chloride con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ef3c1002c85b53a4cdca515c7d64f4
https://europepmc.org/articles/PMC6487927/
https://europepmc.org/articles/PMC6487927/
Publikováno v:
Journal of Neurogastroenterology and Motility
Smooth muscle layers of the gastrointestinal tract consist of a heterogeneous population of cells that include enteric neurons, several classes of interstitial cells of mesenchymal origin, a variety of immune cells and smooth muscle cells (SMCs). Ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2d35b1f65af56d7a1cadff6fce4c6d
https://doi.org/10.5056/jnm14060
https://doi.org/10.5056/jnm14060
Autor:
Jason R. Rock, Kenton M. Sanders, David M. Pardo, Peter J. Blair, Sung Jin Hwang, Sean M. Ward
Publikováno v:
Translational Andrology and Urology
Objective There is a growing body of evidence that gastrointestinal smooth muscle excitability is regulated by several different classes of interstitial cells [interstitial cells of Cajal (ICC) and PDGFRα(+) cells] that are electrically coupled to S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0142d7fdcdf023e07a00aa8b237a5d6
http://europepmc.org/articles/PMC5143232
http://europepmc.org/articles/PMC5143232
Publikováno v:
Cell and Tissue Research. 350:199-213
Kit immunohistochemistry and confocal reconstructions have provided detailed 3-dimensional images of ICC networks throughout the gastrointestinal (GI) tract. Morphological criteria have been used to establish that different classes of ICC exist withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6bd15992c9fdb23c0110e6c6e832f2
https://doi.org/10.1007/s00441-012-1468-7
https://doi.org/10.1007/s00441-012-1468-7
Publikováno v:
Neurogastroenterology & Motility. 24:e437-e449
Background Morphological studies have revealed a close anatomical relationship between enteric nerve terminals and intramuscular ICC (ICC-IM) which supports a role for ICC-IM as intermediaries in enteric motor neurotransmission. Recently, a second ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79ef8f67ee33d64e89942d583d079e78
https://doi.org/10.1111/j.1365-2982.2012.01975.x
https://doi.org/10.1111/j.1365-2982.2012.01975.x
Autor:
Peter J. Blair, Sean M. Ward, Violeta N. Mutafova-Yambolieva, Leonie Durnin, Sung Jin Hwang, Kenton M. Sanders
Publikováno v:
The Journal of Physiology. 590:1957-1972
Activation of enteric inhibitory motor neurons causes inhibitory junctional potentials (IJPs) and muscle relaxation in mammalian gastrointestinal (GI) muscles, including humans. IJPs in many GI muscles are bi-phasic with a fast initial hyperpolarizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eccb8be36845f2eca79100ef5f795f0b
https://doi.org/10.1113/jphysiol.2011.224634
https://doi.org/10.1113/jphysiol.2011.224634
Autor:
Kenton M. Sanders, Peter J. Blair, Sean M. Ward, Grant W. Hennig, Sung Jin Hwang, Kate E O'Driscoll, Jason R. Rock, Brian D. Harfe, Yulia Bayguinov, Fiona C. Britton
Publikováno v:
The Journal of Physiology. 587:4887-4904
Specialized cells, referred to as interstitial cells of Cajal (ICC), generate and actively propagate the spontaneous electrical activity known as slow waves in the gastrointestinal (GI) tract (Ward et al. 1994, Huizinga et al. 1995; Sanders, 1996). S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a28155d322279aa5925c8cbd78308ab1
https://doi.org/10.1113/jphysiol.2009.176198
https://doi.org/10.1113/jphysiol.2009.176198