Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Peter J Artymiuk"'
Autor:
Magdah Ganash, Danh Phung, Svetlana E Sedelnikova, Toril Lindbäck, Per Einar Granum, Peter J Artymiuk
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74748 (2013)
The structure of NheA, a component of the Bacillus cereus Nhe tripartite toxin, has been solved at 2.05 Å resolution using selenomethionine multiple-wavelength anomalous dispersion (MAD). The structure shows it to have a fold that is similar to the
Externí odkaz:
https://doaj.org/article/0ea8e6cebd924f57ad8fd946c1b91b3f
Autor:
Jon R. Sayers, Min Feng, Faizah A AlMalki, Tom Ceska, John B. Rafferty, Claudia S. Flemming, Svetlana E. Sedelnikova, Jing Zhang, Peter J. Artymiuk
Publikováno v:
Nature structural & molecular biology
Maintenance of genome integrity requires that branched nucleic acid molecules are\ud accurately processed to produce double-helical DNA. Flap endonucleases are essential\ud enzymes that trim such branched molecules generated by Okazaki fragment synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de16c526acbc77b49d43dfd0aaae58b
https://doi.org/10.1038/nsmb.3241
https://doi.org/10.1038/nsmb.3241
Publikováno v:
Genetics
Members of the Frizzled family of sevenpass transmembrane receptors signal via the canonical Wnt pathway and also via noncanonical pathways of which the best characterized is the planar polarity pathway. Activation of both canonical and planar polari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea63bdd9759ad9108690f4c0599cd123
https://doi.org/10.1534/genetics.112.144592
https://doi.org/10.1534/genetics.112.144592
Autor:
Jon R. Sayers, Richard J. Ross, Peter J. Artymiuk, Rowena Speak, S. Pradhananga, Ian Wilkinson
Publikováno v:
Scientific Reports
Acromegaly is a human disease of growth hormone (GH) excess with considerable morbidity and increased mortality. Somatostatin analogues are first line medical treatment but the disease remains uncontrolled in up to 40% of patients. GH receptor (GHR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa365a9a9a024f7b8205d7dc6288ad2f
https://doi.org/10.1038/srep35072
https://doi.org/10.1038/srep35072
Autor:
Richard J. Ross, Jon R. Sayers, Aiden H. Riley, Colin Gray, Peter J. Artymiuk, Yahia A Kaabi, Ian Wilkinson, David C. James, F Guesdon
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 32, Iss 6 (2012)
Bioscience Reports, Vol 32, Iss 6 (2012)
We have investigated the interaction between GH (growth hormone) and GHR (GH receptor). We previously demonstrated that a truncated GHR that possesses a transmembrane domain but no cytoplasmic domain blocks receptor signalling. Based on this observat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25b3437512761cdd92343e1c0d24bb7
http://europepmc.org/articles/PMC3497723
http://europepmc.org/articles/PMC3497723
Publikováno v:
Nucleic Acids Research
Similarities in the 3D patterns of RNA base interactions or arrangements can provide insights into their functions and roles in stabilization of the RNA 3D structure. Nucleic Acids Search for Substructures and Motifs (NASSAM) is a graph theoretical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af46437b6f0d7143a769fa9a16d0cfb
http://europepmc.org/articles/PMC3394293
http://europepmc.org/articles/PMC3394293
Autor:
S. Pradhananga, Ian Wilkinson, Jon R. Sayers, Caroline Touvay, Peter J. Artymiuk, Carol Kinoshita, Eric Ferrandis, Zida Wu, Kevin Stafford, Christian J. Strasburger, Richard J. Ross
Publikováno v:
Clinical Science. 119:483-491
A fundamental concern for all new biological therapeutics is the possibility of inducing an immune response. We have recently demonstrated that an LR-fusion (ligand–receptor fusion) of growth hormone generates a potent long-acting agonist; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cd8f90a7988d8016b891e8545a1be6
https://doi.org/10.1042/cs20100241
https://doi.org/10.1042/cs20100241
Autor:
Arthur J. G. Moir, Stuart Hunt, Peter J. Artymiuk, Per A. Bullough, Jeffrey Green, Svetomir B. Tzokov
Publikováno v:
Microbiology. 154:633-642
Some enteric bacteria synthesize a pore-forming toxin, HlyE, which is cytolytic and cytotoxic to host cells. Measurement of HlyE binding to erythrocyte ghosts and the kinetics of HlyE-mediated erythrocyte lysis suggests that interaction with target m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8e59fc102b36291e6c26f00a5266d1
https://doi.org/10.1099/mic.0.2007/011700-0
https://doi.org/10.1099/mic.0.2007/011700-0
Publikováno v:
AIP Conference Proceedings.
A fundamental understanding of the atomic level interactions in ribonucleic acid (RNA) and how they contribute towards RNA architecture is an important knowledge platform to develop through the discovery of motifs from simple arrangements base pairs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd8260447bdbefa45be9e7fc720a5fd2
https://doi.org/10.1063/1.4931240
https://doi.org/10.1063/1.4931240
Autor:
Michael J. Gasson, Peter J. Artymiuk, Claire Shearman, Per A. Bullough, Svetomir B. Tzokov, Timothy J. Stillman, Maria Carradus, Colin H. Williams, Jeffrey Green, Svetlana E. Sedelnikova, Valia A. Norte, Manisha Upadhyay
Publikováno v:
Molecular Microbiology. 57:1101-1112
Summary Dps proteins play a major role in the protection of bacterial DNA from damage by reactive oxygen spe- cies. Previous studies have implicated the extended lysine-containing N-terminal regions of Dps subunits in DNA binding, but this part of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62153d1891b6e1c01efc96338c5e5672
https://doi.org/10.1111/j.1365-2958.2005.04757.x
https://doi.org/10.1111/j.1365-2958.2005.04757.x