The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate.

Autor: Charles Brabin, Peter J Appleford, Alison Woollard

Publikováno v: PLoS Genetics, Vol 7, Iss 8, p e1002200 (2011)

Seam cells in Caenorhabditis elegans provide a paradigm for the stem cell mode of division, with the ability to both self-renew and produce daughters that differentiate. The transcription factor RNT-1 and its DNA binding partner BRO-1 (homologues of

Externí odkaz: https://doaj.org/article/594f6954e74c4f93878ddc87dbc3f4c7

Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number

Autor: Ritobrata Ghose, Jeroen S. van Zon, Peter J. Appleford, Alison Woollard, Sneha L. Koneru, Dimitris Katsanos, Nicola Gritti, Lamia Mestek Boukhibar, Michalis Barkoulas, Richard J. Poole, Maria Doitsidou

Publikováno v: PLOS Biology
PLoS Biology, Vol 15, Iss 11, p e2002429 (2017)
PLoS Biology
Katsanos, D, Koneru, S L, Mestek Boukhibar, L, Gritti, N, Ghose, R, Appleford, P J, Doitsidou, M, Woollard, A, van Zon, J S, Poole, R J & Barkoulas, M 2017, ' Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number ', PLoS Biology, vol. 15, no. 11, pp. e2002429 . https://doi.org/10.1371/journal.pbio.2002429

Biological systems are subject to inherent stochasticity. Nevertheless, development is remarkably robust, ensuring the consistency of key phenotypic traits such as correct cell numbers in a certain tissue. It is currently unclear which genes modulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf74ca806e2d52f91f00232a26772f6f

unc-4 and dve-1 regulate expression of the mab-9 T-box gene

Autor: Alison Woollard, Peter J. Appleford, Gholamali Jafari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c201aea59f843fa553cfb0091e6685
https://doi.org/10.1016/j.cbpa.2008.04.248

Identification of cis-regulatory elements from the C. elegans T-box gene mab-9 reveals a novel role for mab-9 in hypodermal function

Autor: Toby Braun, Peter J. Appleford, Maria J. Gravato-Nobre, Alison Woollard

Publikováno v: Developmental Biology. 317(2):695-704

We have identified Conserved Non-coding Elements (CNEs) in the regulatory region of Caenorhabditis elegans and Caenorhabditis briggsae mab-9, a T-box gene known to be important for cell fate specification in the developing C. elegans hindgut. Two adj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e55da86b9a613918ec3756df1c2434

Strain and stage specific variation in Toxoplasma gondii antigens

Autor: Peter J. Appleford, Judith E. Smith

Publikováno v: International Journal for Parasitology. 30:1187-1191

The antigenic profile of virulent (RH, ENT, Martin) and avirulent (RRA, DEG, ME49) Toxoplasma strains was compared directly by western blotting using a panel of immune mouse sera. Dominant antigens of approximate MR 30–33, 21 and 25×103 were commo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec761c1105c77804eb36107d583d7b9
https://doi.org/10.1016/s0020-7519(00)00109-0