Challenges of early renal cancer detection: symptom patterns and incidental diagnosis rate in a multicentre prospective UK cohort of patients presenting with suspected renal cancer

Autor: Michelle Wilson, Naveen S Vasudev, Grant D Stewart, Adebanji Adeyoju, Jon Cartledge, Michael Kimuli, Shibendra Datta, Damian Hanbury, David Hrouda, Grenville Oades, Poulam Patel, Naeem Soomro, Mark Sullivan, Jeff Webster, Peter J Selby, Rosamonde E Banks

Publikováno v: BMJ Open, Vol 10, Iss 5 (2020)

Objectives To describe the frequency and nature of symptoms in patients presenting with suspected renal cell carcinoma (RCC) and examine their reliability in achieving early diagnosis.Design Multicentre prospective observational cohort study.Setting

Externí odkaz: https://doaj.org/article/6cfcf49e402e4693a956dc28fe5252e7

Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Autor: Ghislaine Scelo, Mark P. Purdue, Kevin M. Brown, Mattias Johansson, Zhaoming Wang, Jeanette E. Eckel-Passow, Yuanqing Ye, Jonathan N. Hofmann, Jiyeon Choi, Matthieu Foll, Valerie Gaborieau, Mitchell J. Machiela, Leandro M. Colli, Peng Li, Joshua N. Sampson, Behnoush Abedi-Ardekani, Celine Besse, Helene Blanche, Anne Boland, Laurie Burdette, Amelie Chabrier, Geoffroy Durand, Florence Le Calvez-Kelm, Egor Prokhortchouk, Nivonirina Robinot, Konstantin G. Skryabin, Magdalena B. Wozniak, Meredith Yeager, Gordana Basta-Jovanovic, Zoran Dzamic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Neonila Szeszenia-Dabrowska, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Laura Baglietto, Heiner Boeing, Kay-Tee Khaw, Elisabete Weiderpass, Borje Ljungberg, Raviprakash T. Sitaram, Fiona Bruinsma, Susan J. Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J. Vatten, Tony Fletcher, Kvetoslava Koppova, Susanna C. Larsson, Alicja Wolk, Rosamonde E. Banks, Peter J. Selby, Douglas F. Easton, Paul Pharoah, Gabriella Andreotti, Laura E. Beane Freeman, Stella Koutros, Demetrius Albanes, Satu Männistö, Stephanie Weinstein, Peter E. Clark, Todd L. Edwards, Loren Lipworth, Susan M. Gapstur, Victoria L. Stevens, Hallie Carol, Matthew L. Freedman, Mark M. Pomerantz, Eunyoung Cho, Peter Kraft, Mark A. Preston, Kathryn M. Wilson, J. Michael Gaziano, Howard D. Sesso, Amanda Black, Neal D. Freedman, Wen-Yi Huang, John G. Anema, Richard J. Kahnoski, Brian R. Lane, Sabrina L. Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L. Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I-Min Lee, Wong-Ho Chow, Lee E. Moore, Christopher Wood, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C. Leibovich, Toni K. Choueiri, G. Mark Lathrop, Nathaniel Rothman, Jean-Francois Deleuze, James D. McKay, Alexander S. Parker, Xifeng Wu, Richard S. Houlston, Paul Brennan, Stephen J. Chanock

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

Risk for renal cell carcinoma (RCC) is higher when there are first-degree family members with the disease. Here, Scelo and colleagues perform a genome-wide association meta-analysis and new genome-wide scan to identify seven new loci with significant

Externí odkaz: https://doaj.org/article/ad47bc9f89b649d087928811441ea01d

Supplementary Figure 3 from Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from First-Line Treatment

Autor: Richard G. Vile, Alan Melcher, Kevin J. Harrington, Peter J. Selby, Hardev Pandha, Jose S. Pulido, Matt Coffey, Reuben S. Harris, Karen Kaluza Smith, Elizabeth J. Ilett, Phonphimon Wongthida, Kevin G. Shim, Matthew Schuelke, Christopher B. Driscoll, Amy M. Molan, Jill Thompson, Timothy Kottke, Amanda L. Huff, Laura Evgin

Suppl Fig 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2df2dac03c88594d6ea75552686923
https://doi.org/10.1158/2326-6066.22537064.v1

Supplementary Figure 6 from Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from First-Line Treatment

Autor: Richard G. Vile, Alan Melcher, Kevin J. Harrington, Peter J. Selby, Hardev Pandha, Jose S. Pulido, Matt Coffey, Reuben S. Harris, Karen Kaluza Smith, Elizabeth J. Ilett, Phonphimon Wongthida, Kevin G. Shim, Matthew Schuelke, Christopher B. Driscoll, Amy M. Molan, Jill Thompson, Timothy Kottke, Amanda L. Huff, Laura Evgin

Suppl Fig 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c424bb33f2ad0c4b1d5bd3983f66e1a
https://doi.org/10.1158/2326-6066.22537052

Supplementary Methods S1 from Application of Genomic Sequencing to Refine Patient Stratification for Adjuvant Therapy in Renal Cell Carcinoma

Autor: Rosamonde E. Banks, Yasser Riazalhosseini, Mark Lathrop, Paul Brennan, Jörg Tost, Alvis Brazma, Guillaume Bourque, Anne Cambon-Thomsen, Bozidar Kovacevic, Ljiljana Bogdanovic, Viorel Jinga, Dana Mates, Marie Navratilova, Lenka Foretova, Oxana Shangina, Anush Moukeria, David Zaridze, Estelle Chanudet, Vladimir Janout, Antonin Brisuda, Ivana Holcatova, Magdalena B. Wozniak, Poulam M. Patel, Adebanji Adeyoju, Naeem Soomro, Jon Cartledge, Michael Kimuli, Sebastian Trainor, Peter J. Selby, Anne Y. Warren, Behnoush Abedi-Ardekani, Sharon M. Jackson, Edgars Celms, Juris Viksna, Lars Egevad, Antoine Paccard, Madeleine Arseneault, Nazanin Nourbehesht, Robert Eveleigh, Louis Letourneau, Michelle Wilson, Kate I. Glennon, Ghislaine Scelo, Naveen S. Vasudev

Supplementary Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65313f8ad3eddf184684c4275925538b
https://doi.org/10.1158/1078-0432.22495080