Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Peter Järver"'
Autor:
Kariem Ezzat, Maria Pernemalm, Sandra Pålsson, Thomas C. Roberts, Peter Järver, Aleksandra Dondalska, Burcu Bestas, Michal J. Sobkowiak, Bettina Levänen, Magnus Sköld, Elizabeth A. Thompson, Osama Saher, Otto K. Kari, Tatu Lajunen, Eva Sverremark Ekström, Caroline Nilsson, Yevheniia Ishchenko, Tarja Malm, Matthew J. A. Wood, Ultan F. Power, Sergej Masich, Anders Lindén, Johan K. Sandberg, Janne Lehtiö, Anna-Lena Spetz, Samir EL Andaloussi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The protein corona around artificial nanoparticles is known to influence activity and biological fate, the formation around viruses is less well understood. Here, the authors observe the formation of protein corona on viruses and study the effects th
Externí odkaz:
https://doaj.org/article/707b1edf615a4fe08fe6eacaded85b36
Autor:
Peter Järver, Aleksandra Dondalska, Candice Poux, AnnSofi Sandberg, Joseph Bergenstråhle, Annette E. Sköld, Nathalie Dereuddre-Bosquet, Fréderic Martinon, Sandra Pålsson, Eman Zaghloul, David Brodin, Birgitta Sander, Kim A. Lennox, Mark A. Behlke, Samir EL-Andaloussi, Janne Lehtiö, Joakim Lundeberg, Roger LeGrand, Anna-Lena Spetz
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract Recognition of nucleic acids by endosomal Toll-like receptors (TLR) is essential to combat pathogens, but requires strict control to limit inflammatory responses. The mechanisms governing this tight regulation are unclear. We found that sing
Externí odkaz:
https://doaj.org/article/8ee60f6cd9e941b7b20a1654b77636dc
Autor:
Candice Poux, Aleksandra Dondalska, Joseph Bergenstråhle, Sandra Pålsson, Vanessa Contreras, Claudia Arasa, Peter Järver, Jan Albert, David C. Busse, Roger LeGrand, Joakim Lundeberg, John S. Tregoning, Anna-Lena Spetz
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The initiation of an immune response is dependent on the activation and maturation of dendritic cells after sensing pathogen associated molecular patterns by pattern recognition receptors. However, the response needs to be balanced as excessive pro-i
Externí odkaz:
https://doaj.org/article/15ac5559956a41ec8c1585cb51e3c25a
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56597 (2013)
Affinity proteins binding to antibody constant regions have proved to be invaluable tools in biotechnology. Here, protein engineering was used to expand the repertoire of available immunoglobulin binding proteins via improvement of the binding streng
Externí odkaz:
https://doaj.org/article/0da7970e7b314152a8f4f648a7280c0c
Autor:
Peter Järver, Thibault Coursindel, Samir EL Andaloussi, Caroline Godfrey, Matthew JA Wood, Michael J Gait
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Externí odkaz:
https://doaj.org/article/26969c85402d4af882438039e0d79a44
Autor:
Tatu Lajunen, Ultan F. Power, Osama Saher, Janne Lehtiö, Sergej Masich, Magnus Sköld, Maria Pernemalm, Thomas C. Roberts, Sandra Pålsson, Tarja Malm, Otto K. Kari, Burcu Bestas, Bettina Levänen, Anna-Lena Spetz, Johan K. Sandberg, Michał J. Sobkowiak, Eva Sverremark Ekström, Samir El Andaloussi, Kariem Ezzat, Anders Lindén, Matthew J.A. Wood, Peter Järver, Aleksandra Dondalska, Caroline Nilsson, Yevheniia Ishchenko, Elizabeth A. Thompson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Ezzat, K, Pernemalm, M, Palsson, S, Roberts, T C, Jarver, P, Dondalska, A, Bestas, B, Sobkowiak, M J, Levanen, B, Skold, M, Thompson, E A, Saher, O, Kari, O K, Lajunen, T, Ekstrom, E S, Nilsson, C, Ishchenko, Y, Malm, T, Wood, M J A, Power, U, Masich, S, Linden, A, Sandberg, J K, Lehtio, J, Spetz, A-L & Andaloussi, S EL 2019, ' The Viral protein Corona Directs Viral Pathogenesis and Amyloid Aggregation ', Nature Communications, vol. 10, 2331 . https://doi.org/10.1038/s41467-019-10192-2
Nature Communications
Ezzat, K, Pernemalm, M, Palsson, S, Roberts, T C, Jarver, P, Dondalska, A, Bestas, B, Sobkowiak, M J, Levanen, B, Skold, M, Thompson, E A, Saher, O, Kari, O K, Lajunen, T, Ekstrom, E S, Nilsson, C, Ishchenko, Y, Malm, T, Wood, M J A, Power, U, Masich, S, Linden, A, Sandberg, J K, Lehtio, J, Spetz, A-L & Andaloussi, S EL 2019, ' The Viral protein Corona Directs Viral Pathogenesis and Amyloid Aggregation ', Nature Communications, vol. 10, 2331 . https://doi.org/10.1038/s41467-019-10192-2
Nature Communications
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269bca5334edfffd20bf069b6bd50e65
https://doi.org/10.1101/246785
https://doi.org/10.1101/246785
Autor:
Amer F. Saleh, Ülo Langel, Mattias Hällbrink, Michael J. Gait, Graham McClorey, Samir El Andaloussi, Suzan M. Hammond, Matthew J.A. Wood, C. I. Edvard Smith, Peter Järver, Andrey A. Arzumanov, Eman M. Zaghloul
Publikováno v:
Nucleic Acid Therapeutics
Oligonucleotide analogs have provided novel therapeutics targeting various disorders. However, their poor cellular uptake remains a major obstacle for their clinical development. Negatively charged oligonucleotides, such as 2′-O-Methyl RNA and lock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b4fb2758b64af6424147955c879861
https://doi.org/10.1089/nat.2014.0511
https://doi.org/10.1089/nat.2014.0511
Publikováno v:
Nucleic Acid Therapeutics. 24:37-47
Exon skipping is one of a number of “steric blocking” applications of oligonucleotides (ONs) and their analogues that in recent years have undergone a renaissance and which have led to new therapeutic opportunities (Kurreck, 2008; Kole et al., 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55af69196e59ad733ffdeaa25e2d0b2
https://doi.org/10.1089/nat.2013.0454
https://doi.org/10.1089/nat.2013.0454
Evaluation of backbone-cyclized HER2-binding 2-helix Affibody molecule for In Vivo molecular imaging
Autor:
Hadis Honarvar, Amelie Eriksson Karlström, Karl Andersson, Vladimir Tolmachev, Peter Järver, Nima Jokilaakso, Jennie Malmberg, Anna Orlova, Daniel Rosik
Publikováno v:
Nuclear Medicine and Biology. 40:378-386
Introduction Affibody molecules, small scaffold proteins, have demonstrated an appreciable potential as imaging probes. Affibody molecules are composed of three alpha-helices. Helices 1 and 2 are involved in molecular recognition, while helix 3 provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff54bfe9e9264326aa3cf4d505ddd7bf
https://doi.org/10.1016/j.nucmedbio.2012.12.009
https://doi.org/10.1016/j.nucmedbio.2012.12.009
Transposable elements have emerged as a promising candidate for human non-viral gene-therapy. The Tc1/mariner transposon Sleeping Beauty is to date one of the most efficient transposons in mammals. Sleeping Beauty transposase has so far mostly been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b043f0fed7aea3417b47b9e9b016287
https://doi.org/10.1007/s10989-007-9114-z
https://doi.org/10.1007/s10989-007-9114-z