Zobrazeno 1 - 10 of 260 pro vyhledávání: '"Peter J, Tonge"'
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Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity
Autor: Matthew T. Cifone, YongLe He, Rajeswari Basu, Nan Wang, Shabnam Davoodi, Lauren A. Spagnuolo, Yuanyuan Si, Taraneh Daryaee, Craig E. Stivala, Stephen G. Walker, Peter J. Tonge
Publikováno v: Journal of Medicinal Chemistry. 65:16510-16525
The relationship between drug-target residence time and the post-antibiotic effect (PAE) provides insights into target vulnerability. To probe the vulnerability of bacterial acetyl-CoA carboxylase (ACC), a series of heterobivalent inhibitors were syn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a780495b76d1729fadfc7383408ed03
https://doi.org/10.1021/acs.jmedchem.2c01380
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4
Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis
Autor: Jinnette Tolentino Collado, James N. Iuliano, Katalin Pirisi, Samruddhi Jewlikar, Katrin Adamczyk, Gregory M. Greetham, Michael Towrie, Jeremy R. H. Tame, Stephen R. Meech, Peter J. Tonge, Andras Lukacs
Publikováno v: ACS Chemical Biology. 17:2643-2654
The hydrogen bonding network that surrounds the flavin in Blue Light Utilizing FAD (BLUF) photoreceptors plays a crucial role in sensing and communicating the changes in the electronic structure of the flavin to the protein matrix upon light absorpti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc007b0cff868031a8a5cd4b070fc17
https://doi.org/10.1021/acschembio.2c00575
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6
Impact of Target Turnover on the Translation of Drug-Target Residence Time to Time-Dependent Antibacterial Activity
Autor: Mustufa Babar, Sneha Basak, Fereidoon Daryaee, Rajeswari Basu, Nan Wang, Peter J. Tonge, Stephen G. Walker, Eleanor K. H. Allen, John D. Haley
Publikováno v: ACS Infect Dis
The translation of time-dependent drug-target occupancy to extended pharmacological activity at low drug concentration depends on factors such as target vulnerability and the rate of target turnover. Previously, we demonstrated that the postantibioti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc053469ac1bf09d00c808753f6ea33
https://doi.org/10.1021/acsinfecdis.1c00317
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Akademický článek
The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography.
Autor: Zhuo Zhang, Alvaro A Ordonez, Peter Smith-Jones, Hui Wang, Kayla R Gogarty, Fereidoon Daryaee, Lauren E Bambarger, Yong S Chang, Sanjay K Jain, Peter J Tonge
Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0170871 (2017)
5-[18F]F-pyrazinamide (5-[18F]F-PZA), a radiotracer analog of the first-line tuberculosis drug pyrazinamide (PZA), was employed to determine the biodistribution of PZA using PET imaging and ex vivo analysis. 5-[18F]F-PZA was synthesized in 60 min usi
Externí odkaz: https://doaj.org/article/b645b581b9464ab5b1df345ed1325e5c
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9
Structural Basis for the Regulation of Biofilm Formation and Iron Uptake in A. baumannii by the Blue-Light-Using Photoreceptor, BlsA
Autor: Jarrod B. French, Iva Chitrakar, Jinelle M. Wint, Stephen G. Walker, James N. Iuliano, Helena A. Woroniecka, Peter J. Tonge, Jinnette Tolentino Collado, Yong Le He
Publikováno v: ACS Infectious Diseases. 6:2592-2603
The opportunistic human pathogen, A. baumannii, senses and responds to light using the blue light sensing A (BlsA) photoreceptor protein. BlsA is a blue-light-using flavin adenine dinucleotide (BLUF) protein that is known to regulate a wide variety o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba26f896a27b1348fc03f4b3619a2318
https://doi.org/10.1021/acsinfecdis.0c00156
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