Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Peter J, Peters"'
Autor:
Oren Tzfadia, Abril Gijsbers, Alexandra Vujkovic, Jihad Snobre, Roger Vargas, Klaas Dewaele, Conor J. Meehan, Maha Farhat, Sneha Hakke, Peter J. Peters, Bouke C. de Jong, Axel Siroy, Raimond B. G. Ravelli
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Proteins encoded by the ESX-1 genes of interest are essential for full virulence in all Mycobacterium tuberculosis complex (Mtbc) lineages, the pathogens causing the highest mortality worldwide. Identifying critical regions in these ESX-1-re
Externí odkaz:
https://doaj.org/article/4bf15e6bd66b40e1ba26def65cc251f8
Autor:
Estefanía Lozano‐Andrés, Agustin Enciso‐Martinez, Abril Gijsbers, Andrea Ridolfi, Guillaume Van Niel, Sten F. W. M. Libregts, Cláudio Pinheiro, Martijn J. C. vanHerwijnen, An Hendrix, Marco Brucale, Francesco Valle, Peter J. Peters, Cees Otto, Ger J. A. Arkesteijn, Marca H. M. Wauben
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 11, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EVs) in blood plasma are recognized as potential biomarkers for disease. Although blood plasma is easily obtainable, analysis of EVs at the single particle level is still challenging due to the biological complexity o
Externí odkaz:
https://doaj.org/article/5836cf23d0c543cd83c1f6286a06c431
Autor:
Stephen Adonai Leon-Icaza, Salimata Bagayoko, Romain Vergé, Nino Iakobachvili, Chloé Ferrand, Talip Aydogan, Célia Bernard, Angelique Sanchez Dafun, Marlène Murris-Espin, Julien Mazières, Pierre Jean Bordignon, Serge Mazères, Pascale Bernes-Lasserre, Victoria Ramé, Jean-Michel Lagarde, Julien Marcoux, Marie-Pierre Bousquet, Christian Chalut, Christophe Guilhot, Hans Clevers, Peter J Peters, Virginie Molle, Geanncarlo Lugo-Villarino, Kaymeuang Cam, Laurence Berry, Etienne Meunier, Céline Cougoule
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011559 (2023)
Mycobacterium abscessus (Mabs) drives life-shortening mortality in cystic fibrosis (CF) patients, primarily because of its resistance to chemotherapeutic agents. To date, our knowledge on the host and bacterial determinants driving Mabs pathology in
Externí odkaz:
https://doaj.org/article/dd6af14953434ec98b532b99ba43fe5d
Autor:
Abril Gijsbers, Vanesa Vinciauskaite, Axel Siroy, Ye Gao, Giancarlo Tria, Anjusha Mathew, Nuria Sánchez-Puig, Carmen López-Iglesias, Peter J. Peters, Raimond B.G. Ravelli
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 153-164 (2021)
ESX-1 is a major virulence factor of Mycobacterium tuberculosis, a secretion machinery directly involved in the survival of the microorganism from the immune system defence. It disrupts the phagosome membrane of the host cell through a contact-depend
Externí odkaz:
https://doaj.org/article/bb17f446d6a54f5087b60bddb7ad8098
Autor:
Raimond B. G. Ravelli, Frank J. T. Nijpels, Rene J. M. Henderikx, Giulia Weissenberger, Sanne Thewessem, Abril Gijsbers, Bart W. A. M. M. Beulen, Carmen López-Iglesias, Peter J. Peters
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
There is a need to further improve the automation of cryo-EM sample preparation to make it more easily accessible for non-specialists, reduce sample waste and increase reproducibility. Here, the authors present VitroJet, a single device, where sub-nl
Externí odkaz:
https://doaj.org/article/576baa0f76434676a7786827d52416e0
Autor:
Salimata Bagayoko, Stephen Adonai Leon-Icaza, Miriam Pinilla, Audrey Hessel, Karin Santoni, David Péricat, Pierre-Jean Bordignon, Flavie Moreau, Elif Eren, Aurélien Boyancé, Emmanuelle Naser, Lise Lefèvre, Céline Berrone, Nino Iakobachvili, Arnaud Metais, Yoann Rombouts, Geanncarlo Lugo-Villarino, Agnès Coste, Ina Attrée, Dara W Frank, Hans Clevers, Peter J Peters, Céline Cougoule, Rémi Planès, Etienne Meunier
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009927 (2021)
Regulated cell necrosis supports immune and anti-infectious strategies of the body; however, dysregulation of these processes drives pathological organ damage. Pseudomonas aeruginosa expresses a phospholipase, ExoU that triggers pathological host cel
Externí odkaz:
https://doaj.org/article/ac74c14209964749a163336c8cf869b0
Autor:
Sanne van der Niet, Maaike van Zon, Karin de Punder, Anita Grootemaat, Sofie Rutten, Simone J. C. F. M. Moorlag, Diane Houben, Astrid M. van der Sar, Wilbert Bitter, Roland Brosch, Rogelio Hernandez Pando, Maria T. Pena, Peter J. Peters, Eric A. Reits, Katrin D. Mayer-Barber, Nicole N. van der Wel
Publikováno v:
mSphere, Vol 6, Iss 3 (2021)
For decades, Mycobacterium tuberculosis
Externí odkaz:
https://doaj.org/article/e730026f181142668249df16e8486b5a
Autor:
Casper Berger, Navya Premaraj, Raimond B. G. Ravelli, Kèvin Knoops, Carmen López-Iglesias, Peter J. Peters
Publikováno v:
Nature Methods. 20:499-511
Cryogenic electron microscopy and data processing enable the determination of structures of isolated macromolecules to near-atomic resolution. However, these data do not provide structural information in the cellular environment where macromolecules
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 2, Iss , Pp 100037- (2021)
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Despite decades of research driving advancements in drug development and discovery against TB, it still leads among the causes of deaths due to infectious
Externí odkaz:
https://doaj.org/article/1acd60055e4e4437b5d95dda150e9ae8
Autor:
Su Min Pack, Peter J. Peters
Publikováno v:
Vaccines, Vol 10, Iss 2, p 236 (2022)
SARS-CoV-2 vaccine production has taken us by storm. We aim to fill in the history of concepts and the work of pioneers and provide a framework of strategies employing structural vaccinology. Cryo-electron microscopy became crucial in providing three
Externí odkaz:
https://doaj.org/article/abc9c61b299d4df884dd88d60b8f5f38