Zobrazeno 1 - 10
of 361
pro vyhledávání: '"Peter J, Oefner"'
Autor:
Md Nur A Alam Siddique, Fabian Kellermeier, Martha Ölke, Mingming Zhao, Konrad Büssow, Peter J. Oefner, Anja Lührmann, Katja Dettmer, Roland Lang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Aconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects. ACOD1-itaconate is essential for macrophage-mediated control of the intracellular pathogen Coxiel
Externí odkaz:
https://doaj.org/article/23f2879e75db4e8f8ffeb227a10843fd
Autor:
Kathrin Hammon, Kathrin Renner, Michael Althammer, Florian Voll, Nathalie Babl, Sonja-Maria Decking, Peter J. Siska, Carina Matos, Zugey Elizabeth Cárdenas Conejo, Karina Mendes, Friederike Einwag, Heiko Siegmund, Sabine Iberl, Raffaela S. Berger, Katja Dettmer, Rebecca Schoenmehl, Christoph Brochhausen, Wolfgang Herr, Peter J. Oefner, Michael Rehli, Simone Thomas, Marina Kreutz
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
D-2-hydroxyglutarate (D-2-HG) accumulates in primary acute myeloid leukemia (AML) patients with mutated isocitrate dehydrogenase (IDH) and other malignancies. D-2-HG suppresses antitumor T cell immunity but little is known about potential effects on
Externí odkaz:
https://doaj.org/article/10b1b9a9fb744f37b8e904c18044a165
Autor:
Fadi Fadil, Claudia Samol, Raffaela S. Berger, Fabian Kellermeier, Wolfram Gronwald, Peter J. Oefner, Katja Dettmer
Publikováno v:
Metabolites, Vol 14, Iss 6, p 293 (2024)
It was pointed out to us that we had not followed exactly the IROA TruQuant IQQ Workflow Kit protocol in the experimental part of our work [...]
Externí odkaz:
https://doaj.org/article/6b1266c2316e4bb7a4aea0c8ef5a036b
Autor:
Christian Schmidl, Wolfgang Herr, Nathalie Babl, Sonja-Maria Decking, Florian Voll, Michael Althammer, Ada Sala-Hojman, Roberta Ferretti, Clarissa Korf, Lisa Schmidleithner, Benedikt Nerb, Carina Matos, Gudrun E Koehl, Peter Siska, Christina Bruss, Fabian Kellermeier, Katja Dettmer, Peter J Oefner, Marvin Wichland, Ines Ugele, Christopher Bohr, Shivapriya Ramaswamy, Timo Heinrich, Christian Herhaus, Marina Kreutz, Kathrin Renner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background & Aims Intratumoral lactate accumulation and acidosis impair T-cell function and antitumor immunity. Interestingly, expression of the lactate transporter monocarboxylate transporter (MCT) 4, but not MCT1, turned out to be prognostic for th
Externí odkaz:
https://doaj.org/article/c03d167b710e4bcd97adb742f3e84064
Autor:
Michael Mauermeir, Martha Ölke, Inaya Hayek, Jan Schulze-Luehrmann, Katja Dettmer, Peter J. Oefner, Christian Berens, Christian Menge, Anja Lührmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCoxiella burnetii is a zoonotic pathogen, infecting humans, livestock, pets, birds and ticks. Domestic ruminants such as cattle, sheep, and goats are the main reservoir and major cause of human infection. Infected ruminants are usually asym
Externí odkaz:
https://doaj.org/article/2c135c8d26e84245b63690552ad21a9b
Autor:
Robert Schoeppe, Nathalie Babl, Sonja-Maria Decking, Gabriele Schönhammer, Andreas Siegmund, Christina Bruss, Katja Dettmer, Peter J. Oefner, Linus Frick, Anna Weigert, Jonathan Jantsch, Wolfgang Herr, Michael Rehli, Kathrin Renner, Marina Kreutz
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionGlutamine deficiency is a well-known feature of the tumor environment. Here we analyzed the impact of glutamine deprivation on human myeloid cell survival and function.MethodsDifferent types of myeloid cells were cultured in the absence o
Externí odkaz:
https://doaj.org/article/f75ccd4777814a5299a61f9d76f85a60
Autor:
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.
Externí odkaz:
https://doaj.org/article/fa68c802cf994295ba5c37913f6eb977
Autor:
Yurong Cheng, Pascal Schlosser, Johannes Hertel, Peggy Sekula, Peter J. Oefner, Ute Spiekerkoetter, Johanna Mielke, Daniel F. Freitag, Miriam Schmidts, GCKD Investigators, Florian Kronenberg, Kai-Uwe Eckardt, Ines Thiele, Yong Li, Anna Köttgen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Metabolites are indicators of health and disease; genetic studies can reveal variants influencing their levels. Here, the authors investigate the contribution of rare, exonic variants on the levels of urine metabolites and generate predictions on met
Externí odkaz:
https://doaj.org/article/b5d5b7f5988e4fe4b8e179a7a1c34fcb
Autor:
Yong Li, Yurong Cheng, Francesco Consolato, Guglielmo Schiano, Michael R. Chong, Maik Pietzner, Ngoc Quynh H. Nguyen, Nora Scherer, Mary L. Biggs, Marcus E. Kleber, Stefan Haug, Burulça Göçmen, Marie Pigeyre, Peggy Sekula, Inga Steinbrenner, Pascal Schlosser, Christina B. Joseph, Jennifer A. Brody, Morgan E. Grams, Caroline Hayward, Ulla T. Schultheiss, Bernhard K. Krämer, Florian Kronenberg, Annette Peters, Jochen Seissler, Dominik Steubl, Cornelia Then, Matthias Wuttke, Winfried März, Kai-Uwe Eckardt, Christian Gieger, Eric Boerwinkle, Bruce M. Psaty, Josef Coresh, Peter J. Oefner, Guillaume Pare, Claudia Langenberg, Jürgen E. Scherberich, Bing Yu, Shreeram Akilesh, Olivier Devuyst, Luca Rampoldi, Anna Köttgen
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and related to chronic kidney disease, hypertension, and pathogen defense. To gain in
Externí odkaz:
https://doaj.org/article/214e08c2c25c48b684ea1de9af2965d4
Autor:
Linus Frick, Linda Hinterland, Kathrin Renner, Marion Vogl, Nathalie Babl, Simon Heckscher, Anna Weigert, Susanne Weiß, Joachim Gläsner, Raffaela Berger, Peter J. Oefner, Katja Dettmer, Marina Kreutz, Valentin Schatz, Jonathan Jantsch
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Local tissue acidosis affects anti-tumor immunity. In contrast, data on tissue pH levels in infected tissues and their impact on antimicrobial activity is sparse. In this study, we assessed the pH levels in cutaneous Leishmania lesions. Leishmania ma
Externí odkaz:
https://doaj.org/article/3a7a69f7b3644f4f80e2f827ae3a20e3