Zobrazeno 1 - 10
of 370
pro vyhledávání: '"Peter J, Mohler"'
Autor:
Aaron D. Argall, Holly C. Sucharski-Argall, Luke G. Comisford, Sallie J. Jurs, Jack T. Seminetta, Michael J. Wallace, Casey A. Crawford, Sarah S. Takenaka, Mei Han, Mona El Refaey, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8403 (2024)
Altered ankyrin-R (AnkR; encoded by ANK1) expression is associated with diastolic function, left ventricular remodeling, and heart failure with preserved ejection fraction (HFpEF). First identified in erythrocytes, the role of AnkR in other tissues,
Externí odkaz:
https://doaj.org/article/788ff8b6db97434b9710c167319a61c4
Autor:
Sehyoun Yoon, Marc Dos Santos, Marc P. Forrest, Christopher P. Pratt, Natalia Khalatyan, Peter J. Mohler, Jeffrey N. Savas, Peter Penzes
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112784- (2023)
Summary: Rare genetic variants in ANK2, which encodes ankyrin-B, are associated with neurodevelopmental disorders (NDDs); however, their pathogenesis is poorly understood. We find that mice with prenatal deletion in cortical excitatory neurons and ol
Externí odkaz:
https://doaj.org/article/2e405b575a864345a6945ca6fb17a8ae
Autor:
Eun-A Kwak, Christopher C. Pan, Aaron Ramonett, Sanjay Kumar, Paola Cruz-Flores, Tasmia Ahmed, Hannah R. Ortiz, Jeffrey J. Lochhead, Nathan A. Ellis, Ghassan Mouneimne, Teodora G. Georgieva, Yeon Sun Lee, Todd W. Vanderah, Tally Largent-Milnes, Peter J. Mohler, Thomas J. Hund, Paul R. Langlais, Karthikeyan Mythreye, Nam Y. Lee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Defective angiogenesis remains a high source of morbidity in multiple disorders. Here they show that βIV-spectrin, a membrane-associated cytoskeletal protein, is essential for regulation of endothelial tip cell populations and VEGF signaling during
Externí odkaz:
https://doaj.org/article/9b6fe5a83d2b46eeafef20d5197ddbd4
Autor:
Ning Li, Esthela Artiga, Anuradha Kalyanasundaram, Brian J. Hansen, Amy Webb, Maciej Pietrzak, Brandon Biesiadecki, Bryan Whitson, Nahush A. Mokadam, Paul M. L. Janssen, John D. Hummel, Peter J. Mohler, Halina Dobrzynski, Vadim V. Fedorov
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Heart failure (HF) is frequently accompanied with the sinoatrial node (SAN) dysfunction, which causes tachy-brady arrhythmias and increased mortality. MicroRNA (miR) alterations are associated with HF progression. However, the transcriptome
Externí odkaz:
https://doaj.org/article/d1f3400a06c3430697951538c406b0ec
Autor:
Ning Li, Anuradha Kalyanasundaram, Brian J. Hansen, Esthela J. Artiga, Roshan Sharma, Suhaib H. Abudulwahed, Katelynn M. Helfrich, Galina Rozenberg, Pei-Jung Wu, Stanislav Zakharkin, Sandor Gyorke, Paul ML. Janssen, Bryan A. Whitson, Nahush A. Mokadam, Brandon J. Biesiadecki, Federica Accornero, John D. Hummel, Peter J. Mohler, Halina Dobrzynski, Jichao Zhao, Vadim V. Fedorov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their
Externí odkaz:
https://doaj.org/article/f630452532e74b488261b252cd5af083
Autor:
Holly C. Sucharski, Emma K. Dudley, Jordan Williams, Revati Dewal, Kristin I. Stanford, Peter J. Mohler, Sara N. Koenig
Publikováno v:
JVS - Vascular Science, Vol 3, Iss , Pp 423- (2022)
Externí odkaz:
https://doaj.org/article/e81bd78984ae4eef8bd5e30953d4160d
Autor:
Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey
Publikováno v:
Cells, Vol 11, Iss 19, p 3049 (2022)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete
Externí odkaz:
https://doaj.org/article/63890685f8b04fc6b2be5d434329bc0f
Floppy Mitral Valve/Mitral Valve Prolapse (FMV/MVP): An unrevealed genotype – Phenotype relationship
Autor:
Konstantinos Dean Boudoulas, Antonios A. Pitsis, Efstratios K. Theofilogiannakos, Francesca Madiai, Sara Koenig, Timotheos G. Kelpis, Peter J. Mohler, Ernest L. Mazzaferri, Harisios Boudoulas
Publikováno v:
Hellenic Journal of Cardiology, Vol 61, Iss 5, Pp 354-356 (2020)
Externí odkaz:
https://doaj.org/article/0b50e5fc82ae4ea5918d0231ed33dfca
Autor:
Michael J. Wallace, Mona El Refaey, Pietro Mesirca, Thomas J. Hund, Matteo E. Mangoni, Peter J. Mohler
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND). SND more generally occurs in the elderly population and is a
Externí odkaz:
https://doaj.org/article/12565219d0e44d409486f3ab9e98b4b4
Autor:
Matthew J. Mears, Michael J. Wallace, Jacob S. Yount, Lorri A. Fowler, Penny S. Jones, Peter J. Mohler, Loren E. Wold
Publikováno v:
MethodsX, Vol 8, Iss , Pp 101433- (2021)
Precautionary measures of physical isolation, social distancing, and masks have all aided in controlling the spread of COVID-19. However, detection of the virus is crucial to implement isolation of infected individuals. This paper presents the innova
Externí odkaz:
https://doaj.org/article/390539f0eaa540f6a46d85019efbb577