Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Peter J, McHugh"'
Autor:
Lonnie P. Swift, B. Christoffer Lagerholm, Lucy R. Henderson, Malitha Ratnaweera, Hannah T. Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D. Ulrich, Joseph A. Newman, Christopher J. Schofield, Peter J. McHugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at the break termini. Prior to comple
Externí odkaz:
https://doaj.org/article/cd10c307980d47f8a16e6289838eff95
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/d148412c778249528a51a49c7bf23f14
Autor:
Peter J McHugh
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008616 (2020)
Externí odkaz:
https://doaj.org/article/b2cb3d87df1b486d9ddbfd20c30815d5
Autor:
George E. Ronson, Ann Liza Piberger, Martin R. Higgs, Anna L. Olsen, Grant S. Stewart, Peter J. McHugh, Eva Petermann, Nicholas D. Lakin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair i
Externí odkaz:
https://doaj.org/article/a8b5718ddf664c57b19e95d580a3e43a
Autor:
Patricia Price, Azeem Saleem, Julian Matthews, Johann S. de Bono, Peter J. McHugh, Anna L Olsen, Christopher Slapak, Michael Burgess, Sunil Kadam, Valérie André, Sophie Callies, Michael Lahn, Joanna Davies, Malcolm Ranson, Denis C. Talbot
Purpose: Enhanced tumor cell survival through expression of inhibitors of apoptosis (IAP) is a hallmark of cancer. Survivin, an IAP absent from most normal tissues, is overexpressed in many malignancies and associated with a poorer prognosis. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b2a8492d795bdb92f964c057eacca0
https://doi.org/10.1158/1078-0432.c.6519461
https://doi.org/10.1158/1078-0432.c.6519461
Autor:
Patricia Price, Azeem Saleem, Julian Matthews, Johann S. de Bono, Peter J. McHugh, Anna L Olsen, Christopher Slapak, Michael Burgess, Sunil Kadam, Valérie André, Sophie Callies, Michael Lahn, Joanna Davies, Malcolm Ranson, Denis C. Talbot
Supplementary Figures S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443e92e2bc85658c64b2c5cd9e3055a1
https://doi.org/10.1158/1078-0432.22442798
https://doi.org/10.1158/1078-0432.22442798
Autor:
Valentina Mengoli, Ilaria Ceppi, Aurore Sanchez, Elda Cannavo, Swagata Halder, Sarah Scaglione, Pierre‐Henri Gaillard, Peter J McHugh, Nathalie Riesen, Piergiorgio Pettazzoni, Petr Cejka
Publikováno v:
The EMBO Journal. 42
The Werner Syndrome helicase, WRN, is a promising therapeutic target in cancers with microsatellite instability (MSI). Long-term MSI leads to the expansion of TA nucleotide repeats proposed to form cruciform DNA structures, which in turn cause DNA br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2a3cc95d20ace29de581b40ece9f6d
https://doi.org/10.15252/embj.2022111998
https://doi.org/10.15252/embj.2022111998
Autor:
Marcin Bielinski, Hannah T Baddock, J.A. Newman, S.M.M. Mukhopadhyay, Peter J. McHugh, Christopher J. Schofield, Opher Gileadi, Angeline E Gavard, Adam A Dannerfjord, Yuliana Yosaatmadja
Publikováno v:
Nucleic Acids Research
Artemis (SNM1C/DCLRE1C) is an endonuclease that plays a key role in development of B- and T-lymphocytes and in dsDNA break repair by non-homologous end-joining (NHEJ). Artemis is phosphorylated by DNA-PKcs and acts to open DNA hairpin intermediates g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c17e074069329b662c5ea0feaf7a5aa
https://doi.org/10.1093/nar/gkab693
https://doi.org/10.1093/nar/gkab693
Autor:
Opher Gileadi, Peter J. McHugh, J.A. Newman, Yuliana Yosaatmadja, Christopher J. Schofield, Marcin Bielinski, Hannah T Baddock
Publikováno v:
Nucleic Acids Research
The SNM1 nucleases which help maintain genome integrity are members of the metallo-β-lactamase (MBL) structural superfamily. Their conserved MBL-β-CASP-fold SNM1 core provides a molecular scaffold forming an active site which coordinates the metal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e38fdb74b5fe545ecfc1086d9718ac1
https://doi.org/10.1093/nar/gkab692
https://doi.org/10.1093/nar/gkab692
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179278 (2017)
Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme have previously been shown to induce a DNA damage response and, ultimat
Externí odkaz:
https://doaj.org/article/1ce5dbcd5bfa466089cddf70c7d65c1b