Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Peter J, M Openshaw"'
Autor:
Gu-Lung Lin, Simon B. Drysdale, Matthew D. Snape, Daniel O’Connor, Anthony Brown, George MacIntyre-Cockett, Esther Mellado-Gomez, Mariateresa de Cesare, M. Azim Ansari, David Bonsall, James E. Bray, Keith A. Jolley, Rory Bowden, Jeroen Aerssens, Louis Bont, Peter J. M. Openshaw, Federico Martinon-Torres, Harish Nair, Tanya Golubchik, Andrew J. Pollard, RESCEU Consortium
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Respiratory syncytial virus (RSV) is the leading cause of hospitalisation for respiratory infection in young children. RSV disease severity is known to be age-dependent and highest in young infants, but other correlates of severity, particul
Externí odkaz:
https://doaj.org/article/cf0de01a2b3540ecb73b7d2b7c6334c0
Autor:
Janet M. Lord, Tonny Veenith, Jack Sullivan, Archana Sharma-Oates, Alex G. Richter, Neil J. Greening, Hamish J. C. McAuley, Rachael A. Evans, Paul Moss, Shona C. Moore, Lance Turtle, Nandan Gautam, Ahmed Gilani, Manan Bajaj, Louise V. Wain, Christopher Brightling, Betty Raman, Michael Marks, Amisha Singapuri, Omer Elneima, Peter J. M. Openshaw, Niharika A. Duggal, on behalf of the PHOSP-COVID Study collaborative group, ISARIC4C investigators
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Background The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescenc
Externí odkaz:
https://doaj.org/article/561f02bce68f4540ad8f7537241b5e00
Autor:
Ryan S. Thwaites, Ashley S. S. Uruchurtu, Victor Augusti Negri, Megan E. Cole, Nehmat Singh, Nelisa Poshai, David Jackson, Katja Hoschler, Tina Baker, Ian C. Scott, Xavier Romero Ros, Emma Suzanne Cohen, Maria Zambon, Katrina M. Pollock, Trevor T. Hansel, Peter J. M. Openshaw
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Compared to intramuscular vaccines, nasally administered vaccines have the advantage of inducing local mucosal immune responses that may block infection and interrupt transmission of respiratory pathogens. Live attenuated influenza vaccine (
Externí odkaz:
https://doaj.org/article/7758f7cf5b9244e48ab2a7df62ae80f4
Autor:
Mark Almond, Hugo A. Farne, Millie M. Jackson, Akhilesh Jha, Orestis Katsoulis, Oliver Pitts, Tanushree Tunstall, Eteri Regis, Jake Dunning, Adam J. Byrne, Patrick Mallia, Onn Min Kon, Ken A. Saunders, Karen D. Simpson, Robert J. Snelgrove, Peter J. M. Openshaw, Michael R. Edwards, Wendy S. Barclay, Liam M. Heaney, Sebastian L. Johnston, Aran Singanayagam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms underlying susceptibility are poorly understood. Here, we identify that obese individuals have deficient pulmonary antiviral immune responses in bron
Externí odkaz:
https://doaj.org/article/8d985523dc6242578a25e3fd4216932b
Autor:
Nevena Zivanovic, Deniz Öner, Yann Abraham, Joseph McGinley, Simon B. Drysdale, Joanne G. Wildenbeest, Marjolein Crabbe, Greet Vanhoof, Kim Thys, Ryan S. Thwaites, Hannah Robinson, Louis Bont, Peter J. M. Openshaw, Federico Martinón‐Torres, RESCEU Investigators, Andrew J. Pollard, Jeroen Aerssens
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 12, Pp n/a-n/a (2023)
Abstract Whereas most infants infected with respiratory syncytial virus (RSV) show no or only mild symptoms, an estimated 3 million children under five are hospitalized annually due to RSV disease. This study aimed to investigate biological mechanism
Externí odkaz:
https://doaj.org/article/ac35e4f76db64145b22518aa1ef50b98
Autor:
Hannah Goldswain, Xiaofeng Dong, Rebekah Penrice-Randal, Muhannad Alruwaili, Ghada T. Shawli, Tessa Prince, Maia Kavanagh Williamson, Jayna Raghwani, Nadine Randle, Benjamin Jones, I’ah Donovan-Banfield, Francisco J. Salguero, Julia A. Tree, Yper Hall, Catherine Hartley, Maximilian Erdmann, James Bazire, Tuksin Jearanaiwitayakul, Malcolm G. Semple, Peter J. M. Openshaw, J. Kenneth Baillie, ISARIC4C Investigators, Stevan R. Emmett, Paul Digard, David A. Matthews, Lance Turtle, Alistair C. Darby, Andrew D. Davidson, Miles W. Carroll, Julian A. Hiscox
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein,
Externí odkaz:
https://doaj.org/article/b3d75d58548e46f4b79481a60a9b08d2
Autor:
Bruno Salaun, Jonathan De Smedt, Charlotte Vernhes, Annick Moureau, Deniz Öner, Arangassery Rosemary Bastian, Michel Janssens, Sunita Balla-Jhagjhoorsingh, Jeroen Aerssens, Christophe Lambert, Samuel Coenen, Christopher C. Butler, Simon B. Drysdale, Joanne G. Wildenbeest, Andrew J. Pollard, Peter J. M. Openshaw, Louis Bont
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with
Externí odkaz:
https://doaj.org/article/67a78a025c7a47168be51ac3c6f1535b
Autor:
Eleanor Parker, Jordan Thomas, Kelly J. Roper, Samreen Ijaz, Tansy Edwards, Federica Marchesin, Ksenia Katsanovskaja, Lauren Lett, Christopher Jones, Hayley E. Hardwick, Chris Davis, Elen Vink, Sarah E. McDonald, Shona C. Moore, Steve Dicks, Keerthana Jegatheesan, Nicola J. Cook, Joshua Hope, Peter Cherepanov, Myra O. McClure, J. Kenneth Baillie, Peter J. M. Openshaw, Lance Turtle, Antonia Ho, Malcolm G. Semple, William A. Paxton, Richard S. Tedder, Georgios Pollakis, ISARIC4C Investigators
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The SARS-CoV-2 pandemic enables the analysis of immune responses induced against a novel coronavirus infecting immunologically naïve individuals. This provides an opportunity for analysis of immune responses and associations with age, sex and diseas
Externí odkaz:
https://doaj.org/article/a240e6b9bd6a4eef8a86c9b57f47b940
Autor:
Jonathan E. Millar, Lucile Neyton, Sohan Seth, Jake Dunning, Laura Merson, Srinivas Murthy, Clark D. Russell, Sean Keating, Maaike Swets, Carole H. Sudre, Timothy D. Spector, Sebastien Ourselin, Claire J. Steves, Jonathan Wolf, Annemarie B. Docherty, Ewen M. Harrison, Peter J. M. Openshaw, Malcolm G. Semple, J. Kenneth Baillie, ISARIC-4C
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract COVID-19 is clinically characterised by fever, cough, and dyspnoea. Symptoms affecting other organ systems have been reported. However, it is the clinical associations of different patterns of symptoms which influence diagnostic and therapeu
Externí odkaz:
https://doaj.org/article/dd82bb16bfa84fd290d8ce57abc1ca37
Autor:
Lance Turtle, Mathew Thorpe, Thomas M Drake, Maaike Swets, Carlo Palmieri, Clark D Russell, Antonia Ho, Stephen Aston, Daniel G Wootton, Alex Richter, Thushan I de Silva, Hayley E Hardwick, Gary Leeming, Andy Law, Peter J M Openshaw, Ewen M Harrison, ISARIC4C investigators, J Kenneth Baillie, Malcolm G Semple, Annemarie B Docherty
Publikováno v:
PLoS Medicine, Vol 20, Iss 1, p e1004086 (2023)
BackgroundImmunocompromised patients may be at higher risk of mortality if hospitalised with Coronavirus Disease 2019 (COVID-19) compared with immunocompetent patients. However, previous studies have been contradictory. We aimed to determine whether
Externí odkaz:
https://doaj.org/article/4fb1993f132a44399141afa021dbfa59