Zobrazeno 1 - 10
of 1 005
pro vyhledávání: '"Peter J, Hotez"'
Autor:
Syamala Rani Thimmiraju, Rakesh Adhikari, JeAnna R. Redd, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Yi-Lin Chen, Suman Sharma, Amandeep Kaur, Nestor L. Uzcategui, Shannon E. Ronca, Wen-Hsiang Chen, Jason T. Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, Jeroen Pollet
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-5 (2024)
Abstract The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV,
Externí odkaz:
https://doaj.org/article/44e886df60de4b48bf25ffd2242f40b2
Autor:
Peter J. Hotez, Maria Elena Bottazzi, Nelufa Yesmin Islam, Jungsoon Lee, Jeroen Pollet, Cristina Poveda, Ulrich Strych, Syamala Rani Thimmiraju, Nestor L. Uzcategui, Leroy Versteeg, Daniel Gorelick
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 535-545 (2024)
ABSTRACTIntroduction Zebrafishes represent a proven model for human diseases and systems biology, exhibiting physiological and genetic similarities and having innate and adaptive immune systems. However, they are underexplored for human vaccinology,
Externí odkaz:
https://doaj.org/article/7b5259018f2c4102869b765483e32b3f
Autor:
Peter J. Hotez
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-20 (2024)
Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to document and preserve these histories
Externí odkaz:
https://doaj.org/article/4d5878afc1a24f0381d89e78acca70b1
Autor:
Peter J. Hotez, Rakesh Adhikari, Wen-Hsiang Chen, Yi-Lin Chen, Portia Gillespie, Nelufa Y. Islam, Brian Keegan, Rakhi Tyagi Kundu, Jungsoon Lee, Zhuyun Liu, Jason T. Kimata, Numan Oezguen, Jeroen Pollet, Cristina Poveda, Kay Razavi, Shannon E. Ronca, Ulrich Strych, Syamala R. Thimmiraju, Leroy Versteeg, Maria Jose Villar-Mondragon, Junfei Wei, Bin Zhan, Maria Elena Bottazzi
Publikováno v:
Expert Review of Vaccines, Vol 22, Iss 1, Pp 495-500 (2023)
Introduction The development of a yeast-expressed recombinant protein-based vaccine technology co-developed with LMIC vaccine producers and suitable as a COVID-19 vaccine for global access is described. The proof-of-concept for developing a SARS-CoV-
Externí odkaz:
https://doaj.org/article/9dc912870f71410b853d29ac8af90252
Autor:
Zongyuan Liu, Rebecca Ulrich vonBargen, April L. Kendricks, Kate Wheeler, Ana Carolina Leão, Krithivasan Sankaranarayanan, Danya A. Dean, Shelley S. Kane, Ekram Hossain, Jeroen Pollet, Maria Elena Bottazzi, Peter J. Hotez, Kathryn M. Jones, Laura-Isobel McCall
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Post-infectious conditions present major health burdens but remain poorly understood. In Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that successfully clear T. cruzi do not always improve clinical outcome
Externí odkaz:
https://doaj.org/article/ece30cfd780f4288923b0c11f864e0a8
Autor:
William R. Lykins, Jeroen Pollet, Jessica A. White, Brian Keegan, Leroy Versteeg, Ulrich Strych, Wen-Hsiang Chen, Raodoh Mohamath, Gabi Ramer-Denisoff, Sierra Reed, Samuel Beaver, Alana Gerhardt, Emily A. Voigt, Mark A. Tomai, Robert Sitrin, Robert K. M. Choy, Frederick J. Cassels, Peter J. Hotez, Maria Elena Bottazzi, Christopher B. Fox
Publikováno v:
Frontiers in Drug Delivery, Vol 4 (2024)
Introduction: Since their introduction, adjuvanted recombinant subunit vaccines against COVID-19 have played a pivotal role in protecting global populations. Optimizing the immune response’s quality, amplitude, and durability to these vaccines depe
Externí odkaz:
https://doaj.org/article/f548c0f6edd64e56889f7e3269b838a0
Autor:
Duc Minh Nguyen, Cristina Poveda, Jeroen Pollet, Fabian Gusovsky, Maria Elena Bottazzi, Peter J Hotez, Kathryn Marie Jones
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011519 (2023)
BackgroundChagas disease, chronic infection with Trypanosoma cruzi, mainly manifests as cardiac disease. However, the liver is important for both controlling parasite burdens and metabolizing drugs. Notably, high doses of anti-parasitic drug benznida
Externí odkaz:
https://doaj.org/article/1a67838d992942c3894c9ef56f930384
Autor:
Lan Yao, Hiam Chemaitelly, Emanuel Goldman, Esayas Kebede Gudina, Asma Khalil, Rahaman Ahmed, Ayorinde Babatunde James, Anna Roca, Mosoka Papa Fallah, Andrew Macnab, William C. Cho, John Eikelboom, Farah Naz Qamar, Peter Kremsner, Miquel Oliu-Barton, Ivan Sisa, Birkneh Tilahun Tadesse, Florian Marks, Lishi Wang, Jerome H. Kim, Xia Meng, Yongjun Wang, Alyce D. Fly, Cong-Yi Wang, Sara W. Day, Scott C. Howard, J. Carolyn Graff, Marcello Maida, Kunal Ray, Carlos Franco-Paredes, Tapfumanei Mashe, Ngashi Ngongo, Jean Kaseya, Nicaise Ndembi, Yu Hu, Maria Elena Bottazzi, Peter J. Hotez, Ken J. Ishii, Gang Wang, Dianjun Sun, Lotfi Aleya, Weikuan Gu
Publikováno v:
EClinicalMedicine, Vol 64, Iss , Pp 102222- (2023)
Summary: In counteracting highly infectious and disruptive respiratory diseases such as COVID-19, vaccination remains the primary and safest way to prevent disease, reduce the severity of illness, and save lives. Unfortunately, vaccination is often n
Externí odkaz:
https://doaj.org/article/abae73e6eb0d4edda474a72fd201eb41
Autor:
Sergio Castañeda, Marina Muñoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramírez
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Alterations caused by Trypanosoma cruzi in the composition of gut microbiome may play a vital role in the host-parasite interactions that shapes physiology and immune responses against infection. Thus, a better understanding of this parasite
Externí odkaz:
https://doaj.org/article/42109869aaae41bdbd1f568d9a619fa6
Autor:
Peter J Hotez, Salim S Abdool Karim, Lois Privor-Dumm, Jerome H Kim, Sarah Gilbert, Didi Thompson, Jean-Louis Excler
Publikováno v:
BMJ Global Health, Vol 8, Iss 6 (2023)
Although significant progress has been made in achieving goals for COVID-19 vaccine access, the quest for equity and justice remains an unfinished agenda. Vaccine nationalism has prompted calls for new approaches to achieve equitable access and justi
Externí odkaz:
https://doaj.org/article/846698c9e26043098c81582539ed6934