Výsledky vyhledávání - "Peter J, Gengo"

ARD-353 [4-((2R,5S)-4-(R)-(4-Diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic Acid], A Novel Nonpeptide δ Receptor Agonist, Reduces Myocardial Infarct Size without Central Effects

Autor: William Pendergast, Kwen-Jen Chang, Garrett J. Gross, Ke Wei, Scott J. O'Neill, Jonathon D. S. Holt, Peter J. Gengo, Michael. J. Watson

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 316:423-430

A novel delta-receptor selective compound, ARD-353 [4-((2R,5S)-4-(R)-(4-diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2, 5-dimethylpiperazin-1-ylmethyl)benzoic acid], was evaluated for activity on infarct size in a rat model of acute myocardial inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3f750a3e67d899e4bcf6aea8f4ceb2
https://doi.org/10.1124/jpet.105.092742

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DPI-3290 [(+)-3-((α-R)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A Mixed Opioid Agonist with Potent Antinociceptive Activity and Limited Effects on Respiratory Function

Autor: Peter J. Gengo, Robert W. McNutt, Ying Fu Su, Kwen-Jen Chang, Hugh O. Pettit, Scott J. O'Neill

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 307:1227-1233

Allyl-2,5-dimethyl-1-piperazines have been of interest as analgesic agents for the management of moderate-to-severe pain. In this study, we compared the antinociceptive properties and respiratory depressant activity of one such agent, (+)-3-((alpha-R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a88fbd2a53724680e810e75fe15985e
https://doi.org/10.1124/jpet.103.054429

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DPI-221 [4-((alpha-s)-alpha-((2s,5r)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: a novel nonpeptide delta receptor agonist producing increased micturition interval in normal rats

Autor: William Pendergast, Ke Wei, Michael. J. Watson, Jonathon D.S. Holt, Scott J. O'Neill, Peter J. Gengo, Kwen-Jen Chang, Jane P. Chang

Publikováno v: The Journal of pharmacology and experimental therapeutics. 315(2)

There is a wealth of information from animal models and clinical opioid-analgesic use that indicates a significant role for opioid receptors in the modulation of bladder activity. The novel benzhydrylpiperazine compound DPI-221 [4-((alpha-S)-alpha-((

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c1bfae6beb88a656f4f818efe7f202
https://pubmed.ncbi.nlm.nih.gov/16020629

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DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity

Autor: Scott J. O'Neill, Peter J. Gengo, Ke Wei, Michael J. Bishop, Robert W. McNutt, Kwen-Jen Chang, Hugh O. Pettit

Publikováno v: The Journal of pharmacology and experimental therapeutics. 307(3)

Compound (+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide (DPI-3290), is one of a series of novel centrally acting agents with potent antinociceptive activity that binds specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627cb28e68af9c755395d87c58883e34
https://pubmed.ncbi.nlm.nih.gov/14534368

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DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function

Autor: Peter J, Gengo, Hugh O, Pettit, Scott J, O'Neill, Ying Fu, Su, Robert, McNutt, Kwen-Jen, Chang

Publikováno v: The Journal of pharmacology and experimental therapeutics. 307(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3a01deddca8bf732c64bae1ae0a9aea
https://pubmed.ncbi.nlm.nih.gov/14534367

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Preclinical neurochemical and electrophysiological profile of 1192U90, a potential antipsychotic

Autor: Peter J. Gengo, Michael J. Durcan, Ching M. Wang, Anne V. Russell, Philip F. Morgan, Ronald M. Norton, Barrett R. Cooper, Stacy A. Jones-Humble, Richard F. Cox, Donald Lyerly, Flora L.M. Tang, Michael J. Watson

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 15(3)

11192U90 was submitted to receptor binding and monoamine uptake assays. It bound potently at serotonin 5-HT2, dopaminergic D2, serotonin 5-HT1A, and adrenergic alpha 1 and alpha 2 receptors. It also bound to dopaminergic D1, serotonin 5-HT3, serotoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6d87f697c4f774b5f233f30d8a0380
https://pubmed.ncbi.nlm.nih.gov/8873105

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Ryanodine action at calcium release channels. 1. importance of hydroxyl substituents

Autor: John E. Casida, Loretta C. Cole, Peter J. Gengo, Phillip R. Jefferies, Todd A. Blumenkopf

Publikováno v: Journal of medicinal chemistry. 39(12)

Ryanodine (1) and dehydroryanodine (2) have a polar face formed by cis-hydroxyls at C-2, C-4, C-6, and C-12. The importance of the hydroxyls to the action of 1 and 2 at the ryanodine receptor (ryr) of calcium release channels is examined at [3H]-1 bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fa21415f77f042fd7b99ffa32547ef
https://pubmed.ncbi.nlm.nih.gov/8691427

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Amrinone combined with dobutamine improves hemodynamics and oxygen delivery without down-regulation of cardiac beta-adrenergic receptor density in porcine endotoxemia

Autor: John R. Dodam, Peter W. Hellyer, Jana L. Jones, Peter J. Gengo

Publikováno v: Shock (Augusta, Ga.). 3(3)

Effects of amrinone (AMR), a phosphodiesterase inhibitor, alone and in combination with dobutamine (DOB), on hemodynamics and O2 delivery were studied during porcine endotoxemia. Pentobarbital-anesthetized pigs were randomly administered either Esche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cfac371c96991c4a3820a68ea20ef1
https://pubmed.ncbi.nlm.nih.gov/7773803

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Cardiac inotropic responses to calcium and forskolin are not altered by prolonged isoproterenol infusion

Autor: Raymond F. Kauffman, Virginia L. Wyss, Barbara G. Utterback, J. Scott Hayes, Peter J. Gengo, Nancy Bowling

Publikováno v: European journal of pharmacology. 187(2)

Effects of prolonged isoproterenol infusion upon the density of cardiac calcium channels, calcium-mediated contractile responses, and the ability of forskolin to enhance tension development and cyclic AMP accumulation were studied in ventricular musc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28813f46526a9c8173977e89d6cf4912
https://pubmed.ncbi.nlm.nih.gov/1703077

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Interaction of phenoxybenzamine with muscarinic receptors and calcium channels

Autor: Fouad Yousif, David J. Triggle, R.A. Janis, Peter J. Gengo

Publikováno v: Biochemical pharmacology. 33(21)

Phenoxybenzamine (POB, 10 −6 –10 −4 M) inhibited the responses of guinea pig ileal longitudinal smooth muscle to both muscarinic agonists and K + -depolarization but was more effective against the agonist-induced responses. POB inhibited bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd92b6a4bebf42ef52b17b758dadfb76
https://pubmed.ncbi.nlm.nih.gov/6093812

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