Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Peter J, Cox"'
Autor:
Wen He, Gareth T. Young, Baohong Zhang, Peter J. Cox, Lily Ting-Yin Cho, Sally John, Sara A. Paciga, Linda S. Wood, Nicolas Danziger, Serena Scollen, Ciara Vangjeli
Publikováno v:
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-6 (2018)
Abstract Background Individuals with an extremely rare inherited condition, termed Congenital Insensitivity to Pain (CIP), do not feel pain in response to noxious stimuli. Variants in SCN9A, encoding the transmembrane voltage-gated sodium channel Nav
Externí odkaz:
https://doaj.org/article/862c2e5ec8fe408fa43dfb860e2efaf2
Autor:
Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Malgorzata A Mis, Anna Wilbrey, Elizabeth C Payne, Alex Gutteridge, Peter J Cox, Rachel Doyle, David Printzenhoff, Zhixin Lin, Brian E Marron, Christopher West, Nigel A Swain, R Ian Storer, Paul A Stupple, Neil A Castle, James A Hounshell, Mirko Rivara, Andrew Randall, Sulayman D Dib-Hajj, Douglas Krafte, Stephen G Waxman, Manoj K Patel, Richard P Butt, Edward B Stevens
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152405 (2016)
Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors. H
Externí odkaz:
https://doaj.org/article/b9af198893454af186b55747950a6251
Autor:
Camille H. Soubrane, Claudia C. Bauer, Gary J. Stephens, Edward B. Stevens, Peter J. Cox, Venetia Owenson, Manoj K. Patel, Graeme S. Cottrell, Matteo Ottolini, Bryan S. Barker, Michael Rigby, Edward Perez-Reyes, Selvi Ince, James A. Hounshell, Hong Lin
Publikováno v:
The Journal of Neuroscience. 38:9186-9201
The putative cache (Ca2+channel and chemotaxis receptor) domain containing 1 (CACHD1) protein has predicted structural similarities to members of the α2δ voltage-gated Ca2+channel auxiliary subunit family. CACHD1 mRNA and protein were highly expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96a0da41285326e674ec480471651597
https://doi.org/10.1523/jneurosci.3572-15.2018
https://doi.org/10.1523/jneurosci.3572-15.2018
Autor:
Christopher William West, Nigel Alan Swain, Peter J. Cox, Joseph S. Warmus, Kiyoyuki Omoto, David C. Pryde, George Salvatore Amato, Steven Michael Reister, Jamie Turner, Brett M Antonio, Aaron C. Gerlach, Brian E. Marron, Karen Padilla, Katrina Yoger, John H. Mahoney
Publikováno v:
ACS Medicinal Chemistry Letters. 8:666-671
A series of TRPA1 antagonists is described which has as its core structure an indazole moiety. The physical properties and in vitro DMPK profiles are discussed. Good in vivo exposure was obtained with several analogs, allowing efficacy to be assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1a69bdcd2bd38c2563a5531fab1a88
https://doi.org/10.1021/acsmedchemlett.7b00140
https://doi.org/10.1021/acsmedchemlett.7b00140
Autor:
Alex Gutteridge, Xing Chen, Eric B. Fauman, Serena Scollen, Melissa R. Miller, Mera Tilley, David A. Hinds, Craig L. Hyde, Youna Hu, Amy V. Jones, Donal Gorman, Daniel Ziemek, Chao Tian, Peter J. Cox, Michael W. Nagle
Publikováno v:
Human Molecular Genetics
Understanding the interaction between humans and mosquitoes is a critical area of study due to the phenomenal burdens on public health from mosquito-transmitted diseases. In this study, we conducted the first genome-wide association studies (GWAS) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e508092e57703b2c0220550fbc4da578
https://doi.org/10.1093/hmg/ddx036
https://doi.org/10.1093/hmg/ddx036
Autor:
David C. Pryde, Brian E. Marron, Peter J. Cox, C. J. Markworth, Joseph S. Warmus, Christopher William West, David Printzenhoff, S. McMurray, Stupple Paul Anthony, Zhixin Lin, Nigel Alan Swain, Mark L. Chapman, C. E. Payne, Ryoichi Suzuki, Gareth Waldron
Publikováno v:
MedChemComm. 8:1255-1267
In this article, we describe the discovery of an aryl ether series of potent and selective Nav1.3 inhibitors. Based on structural analogy to a similar series of compounds we have previously shown bind to the domain IV voltage sensor region of Nav cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::686aba00c31c3db790fd73e2323a9e86
https://doi.org/10.1039/c7md00131b
https://doi.org/10.1039/c7md00131b
Autor:
Craig L. Hyde, Gordon McMurray, Ana Sredic-Rhodes, David A. Hinds, Youna Hu, Donal Gorman, Amy V. Jones, James Bilsland, Nicholas A. Furlotte, Serena Scollen, James R.F. Hockley, Peter J. Cox
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. Genome-wide association study on 11,891 females of European descent for self-reported dysmenorrhea pain severity identified a significant association that colocalises with the NGF locus.
Dys
Dys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74acabc30da531deea300d22d59f075
http://europepmc.org/articles/PMC5436737
http://europepmc.org/articles/PMC5436737
Autor:
Joseph S. Warmus, Sarah Elizabeth Skerratt, Steven M Reister, David C. Pryde, Thomas Ryckmans, J. Turner, Karen M. Padilla, Katrina E. Yoger, A. C. Gerlach, Nigel Alan Swain, G. Amato, Peter J. Cox, C. G. West, Brian E. Marron, David C. Blakemore
Publikováno v:
MedChemComm. 7:2145-2158
A series of potent and selective carboxamide TRPA1 antagonists were identified by a high throughput screen. Structure–activity relationship studies around this series are described, resulting in a highly potent example of the series. Pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::646aab78dfcb415f3cbbd6666b75f640
https://doi.org/10.1039/c6md00387g
https://doi.org/10.1039/c6md00387g
Autor:
Sara A. Paciga, Lily Ting-Yin Cho, Baohong Zhang, Ciara Vangjeli, Sally John, Gareth T. Young, Nicolas Danziger, Wen He, Linda S. Wood, Peter J. Cox, Serena Scollen
Publikováno v:
BMC Medical Genetics
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-6 (2018)
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-6 (2018)
Background Individuals with an extremely rare inherited condition, termed Congenital Insensitivity to Pain (CIP), do not feel pain in response to noxious stimuli. Variants in SCN9A, encoding the transmembrane voltage-gated sodium channel Nav1.7, have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c3ddba98d0f5a9eabacee742da3af2
http://europepmc.org/articles/PMC6057094
http://europepmc.org/articles/PMC6057094
Autor:
Nathan, Brown, Jean, Cambruzzi, Peter J, Cox, Mark, Davies, James, Dunbar, Dean, Plumbley, Matthew A, Sellwood, Aaron, Sim, Bryn I, Williams-Jones, Magdalena, Zwierzyna, David W, Sheppard
Publikováno v:
Progress in medicinal chemistry. 57(1)
Interpretation of Big Data in the drug discovery community should enhance project timelines and reduce clinical attrition through improved early decision making. The issues we encounter start with the sheer volume of data and how we first ingest it b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1901097fbf73603be67fdb09494f2be5
https://pubmed.ncbi.nlm.nih.gov/29680150
https://pubmed.ncbi.nlm.nih.gov/29680150