Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Peter J, Boogaard"'
Publikováno v:
Toxics, Vol 12, Iss 9, p 623 (2024)
1,3-Butadiene (BD) is classified as a human carcinogen, and occupational exposure should be minimized. This study examined the effectiveness of personal protective equipment (PPE) during the clean-up and repair of a storage tank containing sludge con
Externí odkaz:
https://doaj.org/article/334f9a5b239b473983017d50648250e5
Autor:
Quan Shi, Juan-Carlos Carrillo, Michael G. Penman, Jason Manton, Elena Fioravanzo, Robert H. Powrie, Clifford R. Elcombe, Tilly Borsboom-Patel, Yuan Tian, Hua Shen, Peter J. Boogaard
Publikováno v:
Chemical Research in Toxicology 35 (2022) 8
Chemical Research in Toxicology, 35(8), 1383-1392
Chemical Research in Toxicology, 35(8), 1383-1392
To reduce the number of animals and studies needed to fulfill the information requirements as required by Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (EC no. 1907/2006), a read-across approach was used to support appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578f5d7d8706476f04f9ccfc2df7e09a
https://doi.org/10.1021/acs.chemrestox.2c00089
https://doi.org/10.1021/acs.chemrestox.2c00089
Autor:
Danlei Wang, Viktoria Schramm, Jeroen Pool, Eleni Pardali, Annemarijn Brandenburg, Ivonne M. C. M. Rietjens, Peter J. Boogaard
Publikováno v:
Archives of Toxicology, 96, 1109-1131
Archives of Toxicology 96 (2022)
Archives of Toxicology 96 (2022)
Alkyl-substituted PAHs may be present in certain petroleum-derived products and in the environment and may eventually end up in consumer products, such as foodstuffs, cosmetics and pharmaceuticals. Safety concerns over possible exposure to alkylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ecc2ec0676ac04aa71e207a694906e
https://doi.org/10.1007/s00204-022-03239-9
https://doi.org/10.1007/s00204-022-03239-9
Autor:
Peter J. Boogaard
Publikováno v:
Critical Reviews in Toxicology 52 (2023) 10
Critical Reviews in Toxicology, 52(10), 799-810
Critical Reviews in Toxicology, 52(10), 799-810
Historically, benzene has been widely used in a large variety of applications. Occupational exposure limits (OELs) were set for benzene as it was found to be acutely toxic, causing central nervous system depression at high exposures. OELs were lowere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f497638b9b71a8786ac23325b43aea9d
https://research.wur.nl/en/publications/human-biomonitoring-of-low-level-benzene-exposures
https://research.wur.nl/en/publications/human-biomonitoring-of-low-level-benzene-exposures
Autor:
Peter J. Boogaard, Jochen Buschmann, Wolfgang Koch, Hans B. Ketelslegers, Rainer Fuhst, Katharina Schwarz, Christine McAlinden, Mathieu Vaissiere, Anna Steneholm, Katharina Blümlein, Dirk Schaudien, Lize Deferme
Publikováno v:
Reproductive Toxicology. 99:15-26
The prenatal developmental toxicity of bitumen fume was tested by nose-only inhalation in the rat. The fumes for exposure were collected from the headspace of a storage tank filled with a bitumen corresponding in composition to an anticipated worst-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e283286da0632d461bdd321c509307
https://doi.org/10.1016/j.reprotox.2020.11.009
https://doi.org/10.1016/j.reprotox.2020.11.009
Autor:
John S, House, Fabian A, Grimm, William D, Klaren, Abigail, Dalzell, Srikeerthana, Kuchi, Shu-Dong, Zhang, Klaus, Lenz, Peter J, Boogaard, Hans B, Ketelslegers, Timothy W, Gant, Ivan, Rusyn, Fred A, Wright
Publikováno v:
ALTEX.
The application of in vitro biological assays as new approach methodologies (NAMs) to support grouping of UVCB (unknown or variable composition, complex reaction products, and biological materials) substances has recently been demonstrated. In additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796ac6f76012776d139cd2018802b1fd
https://doi.org/10.14573/altex.2107051
https://doi.org/10.14573/altex.2107051
Autor:
M. Wehr, Martijn Rooseboom, Peter J. Boogaard, Sylvia Escher, Andreas Karwath, Satinder S. Sarang
Publikováno v:
Regulatory Toxicology and Pharmacology 128 (2022)
Regulatory Toxicology and Pharmacology, 128
Regulatory Toxicology and Pharmacology, 128
Respiratory irritation is an important human health endpoint in chemical risk assessment. There are two established modes of action of respiratory irritation, 1) sensory irritation mediated by the interaction with sensory neurons, potentially stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990415982a930ccf95beafb772f00041
https://doi.org/10.1016/j.yrtph.2021.105089
https://doi.org/10.1016/j.yrtph.2021.105089
Autor:
Danlei Wang, Angelique Groot, Albrecht Seidel, Lulu Wang, Effimia Kiachaki, Peter J. Boogaard, Ivonne M.C.M. Rietjens
Publikováno v:
Chemico-Biological Interactions, 363
Chemico-Biological Interactions 363 (2022)
Chemico-Biological Interactions 363 (2022)
In recent years concerns over consumer exposure to mineral oil aromatic hydrocarbons (MOAH), especially those containing alkylated polycyclic aromatic hydrocarbons (PAHs), have emerged. This is especially due to the fact that some PAHs are known to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa931d26d7ee30e36373f965b4ae48c
https://research.wur.nl/en/publications/the-influence-of-alkyl-substitution-on-the-in-vitro-metabolism-an
https://research.wur.nl/en/publications/the-influence-of-alkyl-substitution-on-the-in-vitro-metabolism-an
Autor:
Jing Fang, Danlei Wang, Nynke I. Kramer, Ivonne M. C. M. Rietjens, Peter J. Boogaard, Lenny Kamelia
Publikováno v:
Journal of Applied Toxicology, 43(6), 845-861
Journal of Applied Toxicology 43 (2022) 6
Journal of Applied Toxicology 43 (2022) 6
The present study evaluated the aryl hydrocarbon receptor (AhR), estrogen receptor-α (ER-α), and retinoic acid receptor (RAR) mediated activities of nine 4- and 5-ring unsubstituted and monomethylated polycyclic aromatic hydrocarbons (PAHs) using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9078ed9b3d381f3b64f3e4f3f0ff8ae
https://research.wur.nl/en/publications/the-role-of-receptor-mediated-activities-of-4-and-5-ring-unsubsti
https://research.wur.nl/en/publications/the-role-of-receptor-mediated-activities-of-4-and-5-ring-unsubsti
Publikováno v:
Toxicology in Vitro 80 (2022)
Toxicology in Vitro, 80
Toxicology in Vitro, 80
The present study evaluates the in vitro developmental toxicity of 4- and 5-ring polycyclic aromatic hydrocarbons (PAHs) including benz[a]anthracene (BaA) and benzo[a]pyrene (BaP) and six of their monomethylated congeners, and dibenz[a,h]anthracene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4a069b5e891b51242c42ae37770a4d
https://pubmed.ncbi.nlm.nih.gov/35033653
https://pubmed.ncbi.nlm.nih.gov/35033653