Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Peter I. Darroch"'
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 11, Pp 2315-2324 (2005)
We report the synthesis and characterization of a novel thiourea derivative of sphingomyelin (AD2765). In vitro assays using pure enzyme and/or cell extracts revealed that this compound inhibited the hydrolysis of BODIPY-conjugated or 14C-labeled sph
Externí odkaz:
https://doaj.org/article/0e3c9696d4ce48b6a8816460f180b6ee
Publikováno v:
CRIS
Universities and funders need robust metrics to help them develop and monitor evidence-based strategies. Metrics are a part, albeit an important part, of the evaluation landscape, and no single metric can paint a holistic picture or inform strategy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b230da5e4844328ab6722d05a4c48ac
This research explores whether and how the societal impact of research can be demonstrated by using proxy measures such as mentions of research in mainstream news media, social media and in policy documents. We explore the use of these measures withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39c1963bc193b0bc140ea3191ab8350
https://research.wur.nl/en/publications/an-explorative-study-on-a-universitys-outreach-in-the-field-of-un
https://research.wur.nl/en/publications/an-explorative-study-on-a-universitys-outreach-in-the-field-of-un
Autor:
Nicholas T. Ktistakis, Kok Choi Kong, Jaclyn S. Long, Kah Fei Wan, Susan Pyne, Peter I. Darroch, Nigel J. Pyne
Publikováno v:
Biochemical Journal. 391:25-32
We have shown previously that LPPs (lipid phosphate phosphatases) reduce the stimulation of the p42/p44 MAPK (p42/p44 mitogen-activated protein kinase) pathway by the GPCR (G-protein-coupled receptor) agonists S1P (sphingosine 1-phosphate) and LPA (l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74158d5a166952697deb597d087b1f25
https://doi.org/10.1042/bj20050342
https://doi.org/10.1042/bj20050342
Publikováno v:
Molecular genetics and metabolism. 95(3)
Herein we describe detailed characterization of four common mutations (L302P, H421Y, R496L and DeltaR608) within the acid sphingomyelinase (ASM) gene causing types A and B Niemann-Pick disease (NPD). In vitro and in situ enzyme assays revealed marked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4932eb25581d8c0b528e1e731d6fd78c
https://pubmed.ncbi.nlm.nih.gov/18815062
https://pubmed.ncbi.nlm.nih.gov/18815062
Publikováno v:
Seminars in celldevelopmental biology. 15(5)
The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719dacd1ba3527389d3859dab55281b3
https://pubmed.ncbi.nlm.nih.gov/15271294
https://pubmed.ncbi.nlm.nih.gov/15271294
Autor:
Ann-Marie Conway, Soma Rakhit, Nigel J. Pyne, Susan Pyne, Peter I. Darroch, Rothwelle J. Tate, Amanda E. McKie
Publikováno v:
Biochemical Society transactions. 27(4)
Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It is released from platelets after their activation with agents such as thrombin [l]. In addition, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c53cc7e7b57bdcb1cc98d415b1fec9d
https://pubmed.ncbi.nlm.nih.gov/10917611
https://pubmed.ncbi.nlm.nih.gov/10917611
Publikováno v:
Biochemical Society Transactions. 29:A118-A118
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7a6ca6334ff42642fbddcfd34872fe9
https://doi.org/10.1042/bst029a118a
https://doi.org/10.1042/bst029a118a
Publikováno v:
Biochemical Society Transactions. 28:A279-A279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::251d4329545d5fd890100a5f9cc5a86f
https://doi.org/10.1042/bst028a279
https://doi.org/10.1042/bst028a279
Publikováno v:
Biochemical Society Transactions. 28:A357-A357
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ee7c51a68393e635121d1333619475
https://doi.org/10.1042/bst028a357a
https://doi.org/10.1042/bst028a357a