Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Peter I Mackenzie"'
Autor:
Tatsuro Nakamura, Naho Yamaguchi, Yuu Miyauchi, Tomoki Takeda, Yasushi Yamazoe, Kiyoshi Nagata, Peter I Mackenzie, Hideyuki Yamada, Yuji Ishii
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Our previous studies have demonstrated functional protein-protein interactions between cytochrome P450 (CYP) 3A and UDP-glucuronosyltransferase (UGT). However, the role of carbohydrate chains of UGTs in the interaction with CYP is not well understood
Externí odkaz:
https://doaj.org/article/b0ce577bd271465cb7a29b9eef60a9f2
Autor:
Yuu Miyauchi, Akane Kimura, Madoka Sawai, Keiko Fujimoto, Yuko Hirota, Yoshitaka Tanaka, Shinji Takechi, Peter I. Mackenzie, Yuji Ishii
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Heterologous expression systems are important for analyzing the effects of genetic factors including single nucleotide polymorphisms on the functions of drug-metabolizing enzymes. In this study, we focused on a baculovirus-mammalian cell (Bac-Mam) ex
Externí odkaz:
https://doaj.org/article/d396e18a4e0a412f92e7c0b6d14f73d8
Publikováno v:
Drug Metabolism Reviews. 54:120-140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::499adfb85ac7b8ceec63a90c7af09e81
https://doi.org/10.1080/03602532.2022.2048846
https://doi.org/10.1080/03602532.2022.2048846
Autor:
Theresa E. Hickey, Peter I. Mackenzie, Wayne D. Tilley, Jason S. Carroll, Jessica L.L. Robinson, Carlos Caldas, Roslin Russell, Apichaya Chanawong, Dhilushi Wijayakumara, Robyn Meech, Gerard A. Tarulli, Luke A. Selth, Dong G. Hu
Word Document with legends for supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230371ea6aaaa4e1ade5b8023763b789
https://doi.org/10.1158/0008-5472.22412508
https://doi.org/10.1158/0008-5472.22412508
Autor:
Theresa E. Hickey, Peter I. Mackenzie, Wayne D. Tilley, Jason S. Carroll, Jessica L.L. Robinson, Carlos Caldas, Roslin Russell, Apichaya Chanawong, Dhilushi Wijayakumara, Robyn Meech, Gerard A. Tarulli, Luke A. Selth, Dong G. Hu
Glucuronidation is an enzymatic process that terminally inactivates steroid hormones, including estrogens and androgens, thereby influencing carcinogenesis in hormone-dependent cancers. While estrogens drive breast carcinogenesis via the estrogen rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a48b384e41efde1421cf1df308c5db2
https://doi.org/10.1158/0008-5472.c.6508455
https://doi.org/10.1158/0008-5472.c.6508455
Autor:
Theresa E. Hickey, Peter I. Mackenzie, Wayne D. Tilley, Jason S. Carroll, Jessica L.L. Robinson, Carlos Caldas, Roslin Russell, Apichaya Chanawong, Dhilushi Wijayakumara, Robyn Meech, Gerard A. Tarulli, Luke A. Selth, Dong G. Hu
Word document containing additional details of materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18606eef70ce71375731cc2ff6f31ed
https://doi.org/10.1158/0008-5472.22412502.v1
https://doi.org/10.1158/0008-5472.22412502.v1
Autor:
Theresa E. Hickey, Peter I. Mackenzie, Wayne D. Tilley, Jason S. Carroll, Jessica L.L. Robinson, Carlos Caldas, Roslin Russell, Apichaya Chanawong, Dhilushi Wijayakumara, Robyn Meech, Gerard A. Tarulli, Luke A. Selth, Dong G. Hu
Supplementary Figure 1. Correlation plots depicting the relationship between UGT2B15 and UGT2B17 mRNA expression in breast cancer. Supplementary Figure 3. Steroid-mediated regulation of GREB1, UGTB215 and UGTB17 in MCF7 cells. Supplementary Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1737e450c5b4caeb16ee8df1211db1
https://doi.org/10.1158/0008-5472.22412499.v1
https://doi.org/10.1158/0008-5472.22412499.v1
Autor:
Theresa E. Hickey, Peter I. Mackenzie, Wayne D. Tilley, Jason S. Carroll, Jessica L.L. Robinson, Carlos Caldas, Roslin Russell, Apichaya Chanawong, Dhilushi Wijayakumara, Robyn Meech, Gerard A. Tarulli, Luke A. Selth, Dong G. Hu
Supplementary Figure 2. Kaplan-Meier survival plots showing relationship between UGTB215 and UGTB17 levels and outcome in distinct breast cancer subtypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0c6a8692a08686b576743d30ae6373
https://doi.org/10.1158/0008-5472.22412511.v1
https://doi.org/10.1158/0008-5472.22412511.v1
Autor:
Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Ross A. McKinnon, Peter I. Mackenzie, Robyn Meech
Publikováno v:
Cancers; Volume 14; Issue 22; Pages: 5708
The human UDP-glycosyltransferase (UGTs) superfamily has a critical role in the metabolism of anticancer drugs and numerous pro/anti-cancer molecules (e.g., steroids, lipids, fatty acids, bile acids and carcinogens). Recent studies have shown wide an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838e2e86e1de9cd4c52660cbce9a8f5f
Publikováno v:
Molecular Pharmacology. 99:488-503
The human UDP-glycosyltransferase (UGT) gene superfamily generates 22 canonical transcripts coding for functional enzymes and also produces nearly 150 variant UGT transcripts through alternative splicing and intergenic splicing. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b755833de388f58ce03d6bc73476b3
https://doi.org/10.1124/molpharm.120.000225
https://doi.org/10.1124/molpharm.120.000225