Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Peter I, Croucher"'
Autor:
Helen M. Gunter, Scott E. Youlten, Andre L. M. Reis, Tim McCubbin, Bindu Swapna Madala, Ted Wong, Igor Stevanovski, Arcadi Cipponi, Ira W. Deveson, Nadia S. Santini, Sarah Kummerfeld, Peter I. Croucher, Esteban Marcellin, Tim R. Mercer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The expression of genes encompasses their transcription into mRNA followed by translation into protein. In recent years, next-generation sequencing and mass spectrometry methods have profiled DNA, RNA and protein abundance in cells. However,
Externí odkaz:
https://doaj.org/article/9596d107d6324684931ffa09eb32bdd9
Autor:
Dylan J. M. Bergen, Qiao Tong, Ankit Shukla, Elis Newham, Jan Zethof, Mischa Lundberg, Rebecca Ryan, Scott E. Youlten, Monika Frysz, Peter I. Croucher, Gert Flik, Rebecca J. Richardson, John P. Kemp, Chrissy L. Hammond, Juriaan R. Metz
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-25 (2022)
Abstract Background Scales are mineralised exoskeletal structures that are part of the dermal skeleton. Scales have been mostly lost during evolution of terrestrial vertebrates whilst bony fish have retained a mineralised dermal skeleton in the form
Externí odkaz:
https://doaj.org/article/852349b6027c4257a4ba094496069336
Autor:
Qihao Ren, Weng Hua Khoo, Alexander P. Corr, Tri Giang Phan, Peter I. Croucher, Sheila A. Stewart
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-16 (2022)
Abstract Background Breast cancer can recur months to decades after an initial diagnosis and treatment. The mechanisms that control tumor cell dormancy remain poorly understood, making it difficult to predict which patients will recur and thus benefi
Externí odkaz:
https://doaj.org/article/22152aae55594e4188f347c69ed564c0
Autor:
Chansavath Phetsouphanh, Weng Hua Khoo, Katherine Jackson, Vera Klemm, Annett Howe, Anupriya Aggarwal, Anouschka Akerman, Vanessa Milogiannakis, Alberto Ospina Stella, Romain Rouet, Peter Schofield, Megan L. Faulks, Hannah Law, Thidarat Danwilai, Mitchell Starr, C. Mee Ling Munier, Daniel Christ, Mandeep Singh, Peter I. Croucher, Fabienne Brilot-Turville, Stuart Turville, Tri Giang Phan, Gregory J. Dore, David Darley, Philip Cunningham, Gail V. Matthews, Anthony D. Kelleher, John J. Zaunders
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundLong-term immunity to SARS-CoV-2 infection, including neutralizing antibodies and T cell-mediated immunity, is required in a very large majority of the population in order to reduce ongoing disease burden.MethodsWe have investigated the ass
Externí odkaz:
https://doaj.org/article/54f0e1950fa84edf8548d013da07f7a4
Autor:
Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, Claudio M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P. Corr, James T. Smith, Sindhu T. Mohanty, John A. Morris, Michelle M. McDonald, Julian M. W. Quinn, Amelia R. McGlade, Nenad Bartonicek, Matt Jansson, Konstantinos Hatzikotoulas, Melita D. Irving, Ana Beleza-Meireles, Fernando Rivadeneira, Emma Duncan, J. Brent Richards, David J. Adams, Christopher J. Lelliott, Robert Brink, Tri Giang Phan, John A. Eisman, David M. Evans, Eleftheria Zeggini, Paul A. Baldock, J. H. Duncan Bassett, Graham R. Williams, Peter I. Croucher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal
Externí odkaz:
https://doaj.org/article/60182d9a653b4b4d9d0b7b34378bcb3e
Autor:
Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J. Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Antonio C. Bianco, Alan Boyde, Eleftheria Zeggini, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and aft
Externí odkaz:
https://doaj.org/article/edbe1f565dfb4cb59b5b96ecd707f7bc
Autor:
Anna L Swan, Christine Schütt, Jan Rozman, Maria Del Mar Muñiz Moreno, Stefan Brandmaier, Michelle Simon, Stefanie Leuchtenberger, Mark Griffiths, Robert Brommage, Piia Keskivali-Bond, Harald Grallert, Thomas Werner, Raffaele Teperino, Lore Becker, Gregor Miller, Ala Moshiri, John R Seavitt, Derek D Cissell, Terrence F Meehan, Elif F Acar, Christopher J Lelliott, Ann M Flenniken, Marie-France Champy, Tania Sorg, Abdel Ayadi, Robert E Braun, Heather Cater, Mary E Dickinson, Paul Flicek, Juan Gallegos, Elena J Ghirardello, Jason D Heaney, Sylvie Jacquot, Connor Lally, John G Logan, Lydia Teboul, Jeremy Mason, Nadine Spielmann, Colin McKerlie, Stephen A Murray, Lauryl M J Nutter, Kristian F Odfalk, Helen Parkinson, Jan Prochazka, Corey L Reynolds, Mohammed Selloum, Frantisek Spoutil, Karen L Svenson, Taylor S Vales, Sara E Wells, Jacqueline K White, Radislav Sedlacek, Wolfgang Wurst, K C Kent Lloyd, Peter I Croucher, Helmut Fuchs, Graham R Williams, J H Duncan Bassett, Valerie Gailus-Durner, Yann Herault, Ann-Marie Mallon, Steve D M Brown, Philipp Mayer-Kuckuk, Martin Hrabe de Angelis, IMPC Consortium
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009190 (2020)
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a ran
Externí odkaz:
https://doaj.org/article/14895730ccd5432c954b9d406684a8d3
Autor:
Mara N. Zeissig, Duncan R. Hewett, Vasilios Panagopoulos, Krzysztof M. Mrozik, L. Bik To, Peter I. Croucher, Andrew C.W. Zannettino, Kate Vandyke
Publikováno v:
Haematologica, Vol 106, Iss 12 (2020)
Multiple myeloma (MM) disease progression is dependent on the ability of MM plasma cells (PC) to egress from the bone marrow (BM), enter the circulation and disseminate to distal BM sites. Expression of the chemokine CXCL12 by BM stromal cells is cru
Externí odkaz:
https://doaj.org/article/6d1b9b271dcc4ee990634f98c7077a89
Autor:
Marie Pereira, Jeong-Hun Ko, John Logan, Hayley Protheroe, Kee-Beom Kim, Amelia Li Min Tan, Peter I Croucher, Kwon-Sik Park, Maxime Rotival, Enrico Petretto, JH Duncan Bassett, Graham R Williams, Jacques Behmoaras
Publikováno v:
eLife, Vol 9 (2020)
Functional characterisation of cell-type-specific regulatory networks is key to establish a causal link between genetic variation and phenotype. The osteoclast offers a unique model for interrogating the contribution of co-regulated genes to in vivo
Externí odkaz:
https://doaj.org/article/3598a6a41082456e82266d54eb35c4ad
Autor:
Imogen Moran, Akira Nguyen, Weng Hua Khoo, Danyal Butt, Katherine Bourne, Clara Young, Jana R. Hermes, Maté Biro, Gary Gracie, Cindy S. Ma, C. Mee Ling Munier, Fabio Luciani, John Zaunders, Andrew Parker, Anthony D. Kelleher, Stuart G. Tangye, Peter I. Croucher, Robert Brink, Mark N. Read, Tri Giang Phan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties
Externí odkaz:
https://doaj.org/article/434c7143b0dc490799e9dd7d746d107f