Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Peter Huypens"'
Autor:
Meriem Ouni, Fabian Eichelmann, Markus Jähnert, Christin Krause, Sophie Saussenthaler, Christiane Ott, Pascal Gottmann, Thilo Speckmann, Peter Huypens, Stefan Wolter, Oliver Mann, Martin Hrabé De Angelis, Johannes Beckers, Henriette Kirchner, Matthias B. Schulze, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101774- (2023)
Objectives: Better disease management can be achieved with earlier detection through robust, sensitive, and easily accessible biomarkers. The aim of the current study was to identify novel epigenetic biomarkers determining the risk of type 2 diabetes
Externí odkaz:
https://doaj.org/article/cbd304180aef4bbdad8c44ce9af6265c
Autor:
Laura Stirm, Peter Huypens, Steffen Sass, Richa Batra, Louise Fritsche, Sara Brucker, Harald Abele, Anita M. Hennige, Fabian Theis, Johannes Beckers, Martin Hrabě de Angelis, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/0a645f5ef2d14b18a78a391a9f8dbc6b
Autor:
Simon I. Dreher, Selina Höckele, Peter Huypens, Martin Irmler, Christoph Hoffmann, Tim Jeske, Maximilian Hastreiter, Anja Moller, Andreas L. Birkenfeld, Hans-Ulrich Häring, Andreas Peter, Johannes Beckers, Martin Hrabě de Angelis, Cora Weigert
Publikováno v:
Cells, Vol 10, Iss 12, p 3443 (2021)
Physical training improves insulin sensitivity and can prevent type 2 diabetes (T2D). However, approximately 20% of individuals lack a beneficial outcome in glycemic control. TGF-β, identified as a possible upstream regulator involved in this low re
Externí odkaz:
https://doaj.org/article/e7802b730a534fd0bc3a53e75827922f
Autor:
Jihyun Kim, Vivian E Fernand, Tara M Henagan, Jeho Shin, Peter Huypens, Susan Newman, Thomas W Gettys, Ji Suk Chang
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159990 (2016)
The β3-adrenergic receptor (AR) signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β3-AR signaling highly induces the expression of transcriptional coactivator PGC-1α and
Externí odkaz:
https://doaj.org/article/14cc82e4d4674e62a87353c90829f043
Autor:
Daniel Gradinger, Oana V. Amarie, Marina Rubey, Johannes Beckers, Jan Rozman, Anna-Lena Amend, Gerhard K. H. Przemeck, Moya Wu, Birgit Rathkolb, Raffaele Teperino, Annette Feuchtinger, Peter Huypens, Martin Hrabě de Angelis, Martin Irmler, Nirav Florian Chhabra, Eckhard Wolf
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Comm. Biol. 3:628 (2020)
Communications Biology
Comm. Biol. 3:628 (2020)
Communications Biology
The transcription factor PAX6 is involved in the development of the eye and pancreatic islets, besides being associated with sleep–wake cycles. Here, we investigated a point mutation in the RED subdomain of PAX6, previously described in a human pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29afe64ec8758c29810e886fd3e7fea
https://doi.org/10.1038/s42003-020-01337-x
https://doi.org/10.1038/s42003-020-01337-x
Autor:
Michael Ristow, Mostafa Bakhti, Peter Huypens, Timo D. Müller, Mark L. Heiman, Susanna M. Hofmann, Alan D. Cherrington, Heiko Lickert, Martin Hrabé de Angelis, Stephen C. Woods, Annette Schürmann, Johannes Beckers, Mary Courtney Moore, Peter J. Havel, Christoffer Clemmensen, Simone Renner, Eckhard Wolf, Martin Klingenspor, Matthias H. Tschöp, Maximilian Kleinert
Publikováno v:
Kleinert, Maximilian; Clemmensen, Christoffer; Hofmann, Susanna M; Moore, Mary C; Renner, Simone; Woods, Stephen C; et al.(2018). Animal models of obesity and diabetes mellitus.. Nature reviews. Endocrinology, 14(3), 140-162. doi: 10.1038/nrendo.2017.161. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3z3879vp
Nature reviews. Endocrinology, vol 14, iss 3
Nature reviews. Endocrinology, vol 14, iss 3
More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5000c9123bd17d3614184e7e32ff2b26
https://doi.org/10.1038/nrendo.2017.161
https://doi.org/10.1038/nrendo.2017.161
Autor:
Christine Wurmser, Johannes Beckers, Anja Böhm, Selina Höckele, Maximilian Hastreiter, Cora Weigert, Peter Huypens, Laura Stirm, Tim Jeske, Christoph Klein, Harald Staiger
Publikováno v:
Bioinformatics
Bioinformatics 35, 4834-4836 (2019)
Bioinformatics 35, 4834-4836 (2019)
Summary Despite their fundamental role in various biological processes, the analysis of small RNA sequencing data remains a challenging task. Major obstacles arise when short RNA sequences map to multiple locations in the genome, align to regions tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05299ebb1b81aa88e783486ca094574c
http://europepmc.org/articles/PMC6853685
http://europepmc.org/articles/PMC6853685
Autor:
M Hrabe de Angelis, Maximilian Hastreiter, HU Häring, Selina Höckele, Anja Böhm, Johannes Beckers, Peter Huypens, Tim Jeske, C Hoffmann, Cora Weigert
Publikováno v:
Diabetologie und Stoffwechsel.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdfa4be8ac9c23cc3d3c211e186e697d
https://doi.org/10.1055/s-0038-1641809
https://doi.org/10.1055/s-0038-1641809
Publikováno v:
Islets. 4:1-9
The ability of the pancreatic β-cells to adapt the rate of insulin release in accordance to changes in circulating glucose levels is essential for glucose homeostasis. Two spatial barriers imposed by the plasma membrane and inner mitochondrial membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad74dcc5e7fa95cba5c45b5ab14832d
https://doi.org/10.4161/isl.18338
https://doi.org/10.4161/isl.18338
Autor:
Peter Huypens, Jamie W. Joseph, Stephanie Schaefer, Renjitha Pillai, Tanya Sheinin, Shawn D. Wettig, Mei Huang
Publikováno v:
Journal of Biological Chemistry. 286:1014-1024
The metabolic pathways that are involved in regulating insulin secretion from pancreatic β-cells are still incompletely understood. One potential regulator of the metabolic phenotype of β-cells is the transcription factor aryl hydrocarbon receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8a56d04ef06d5601b2c8ab81c1bfbf
https://doi.org/10.1074/jbc.m110.149062
https://doi.org/10.1074/jbc.m110.149062