Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Peter Humphries"'
Autor:
Naomi Chadderton, Arpad Palfi, Daniel M. Maloney, Matthew Carrigan, Laura K. Finnegan, Killian S. Hanlon, Ciara Shortall, Mary O’Reilly, Peter Humphries, Lorraine Cassidy, Paul F. Kenna, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 322 (2023)
AAV gene therapy for ocular disease has become a reality with the market authorisation of LuxturnaTM for RPE65-linked inherited retinal degenerations and many AAV gene therapies currently undergoing phase III clinical trials. Many ocular disorders ha
Externí odkaz:
https://doaj.org/article/bd632e8c331249f2b641b632703c689a
Autor:
Daniel M. Maloney, Naomi Chadderton, Sophia Millington-Ward, Arpad Palfi, Ciara Shortall, James J. O’Byrne, Lorraine Cassidy, David Keegan, Peter Humphries, Paul Kenna, Gwyneth Jane Farrar
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Optic Atrophy 1 (OPA1) is a mitochondrially targeted GTPase that plays a pivotal role in mitochondrial health, with mutations causing severe mitochondrial dysfunction and typically associated with Dominant Optic Atrophy (DOA), a progressive blinding
Externí odkaz:
https://doaj.org/article/4b299d0b315044cd94b2e4bfd9480a83
Autor:
Laura Whelan, Adrian Dockery, Niamh Wynne, Julia Zhu, Kirk Stephenson, Giuliana Silvestri, Jacqueline Turner, James J. O’Byrne, Matthew Carrigan, Peter Humphries, David Keegan, Paul F. Kenna, G. Jane Farrar
Publikováno v:
Genes, Vol 11, Iss 1, p 105 (2020)
The Irish national registry for inherited retinal degenerations (Target 5000) is a clinical and scientific program to identify individuals in Ireland with inherited retinal disorders and to attempt to ascertain the genetic cause underlying the diseas
Externí odkaz:
https://doaj.org/article/745b641f03484c6aaa24bd976e07365b
Autor:
Killian S. Hanlon, Naomi Chadderton, Arpad Palfi, Alfonso Blanco Fernandez, Peter Humphries, Paul F. Kenna, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Significant advances in gene therapy have enabled exploration of therapies for inherited retinal disorders, many of which are in preclinical development or clinical evaluation. Gene therapy for retinal conditions has led the way in this growing field
Externí odkaz:
https://doaj.org/article/04cb834d403e47d8ba622955f1dd673d
Autor:
Arpad Palfi, Naomi Chadderton, Mary O'Reilly, Kerstin Nagel-Wolfrum, Uwe Wolfrum, Jean Bennett, Peter Humphries, Paul Kenna, Sophia Millington-Ward, Jane Farrar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Externí odkaz:
https://doaj.org/article/f6fa74f399e04b7e8a9f988e52f52604
Autor:
Adrian Dockery, Kirk Stephenson, David Keegan, Niamh Wynne, Giuliana Silvestri, Peter Humphries, Paul F. Kenna, Matthew Carrigan, G. Jane Farrar
Publikováno v:
Genes, Vol 8, Iss 11, p 304 (2017)
There are an estimated 5000 people in Ireland who currently have an inherited retinal degeneration (IRD). It is the goal of this study, through genetic diagnosis, to better enable these 5000 individuals to obtain a clearer understanding of their cond
Externí odkaz:
https://doaj.org/article/6d7241bd600c4734a42eadfbdcbee7d6
Autor:
Arpad Palfi, Naomi Chadderton, Mary O'Reilly, Kerstin Nagel-Wolfrum, Uwe Wolfrum, Jean Bennett, Peter Humphries, Paul Kenna, Sophia Millington-Ward, Jane Farrar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
As gene therapies for various forms of retinal degeneration progress toward human clinical trial, it will be essential to have a repertoire of safe and efficient vectors for gene delivery to the target cells. Recombinant adeno-associated virus (AAV)
Externí odkaz:
https://doaj.org/article/a385329107234f679f6928e877524be4
Autor:
Magdalena Czekaj, Jochen Haas, Marlen Gebhardt, Thomas Müller-Reichert, Peter Humphries, Jane Farrar, Udo Bartsch, Marius Ader
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41798 (2012)
Cell transplantation to treat retinal degenerative diseases represents an option for the replacement of lost photoreceptor cells. In vitro expandable cells isolated from the developing mammalian retina have been suggested as a potential source for th
Externí odkaz:
https://doaj.org/article/71d825942a7b4d758fb4b39a2f7db775
Autor:
Jeffrey O’Callaghan, Conor Delaney, Merissa O’Connor, Joseph van Batenburg-Sherwood, Martin Schicht, Elke Lütjen-Drecoll, Natalie Hudson, Sorcha Ni Dhubhghaill, Peter Humphries, Chris Stanley, Annahita Keravala, Thomas Chalberg, Matthew S. Lawrence, Matthew Campbell
Publikováno v:
Science Advances
Approximately 80 million people globally are affected by glaucoma, with a projected increase to over 110 million by 2040. Substantial issues surrounding patient compliance remain with topical eye drops, and up to 10% of patients become treatment resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2163670e3efbc40f0669a05cfbd865
https://doi.org/10.1126/sciadv.adf6537
https://doi.org/10.1126/sciadv.adf6537
Autor:
Peter Humphries, Jesse Thorner
Publikováno v:
Transactions of the American Mathematical Society. 375:1801-1824
Let π \pi be a unitary cuspidal automorphic representation of G L n \mathrm {GL}_n over a number field, and let π ~ \widetilde {\pi } be contragredient to π \pi . We prove effective upper and lower bounds of the correct order in the short interval