Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Peter Hortschansky"'
Autor:
André Sachse, Ines Hasenbein, Peter Hortschansky, Klaus D. Schmuck, Stefan Maenz, Bernhard Illerhaus, Peter Kuehmstedt, Roland Ramm, René Huber, Elke Kunisch, Victoria Horbert, Francesca Gunnella, Andreas Roth, Harald Schubert, Raimund W. Kinne
Publikováno v:
Journal of Materials Science: Materials in Medicine, Vol 34, Iss 7, Pp 1-15 (2023)
Abstract Bilateral defects (diameter 8 mm) in the medial tibial head of senile, osteopenic female sheep (n = 48; 9.63 ± 0.10 years; mean ± SEM) were treated with hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP)/dicalcium phosphate dihydrate (
Externí odkaz:
https://doaj.org/article/418d355f135241449c3d1ab3ba2983e4
Autor:
Carsten Schwarz, Patience Eschenhagen, Henrijette Schmidt, Thordis Hohnstein, Christina Iwert, Claudia Grehn, Jobst Roehmel, Eva Steinke, Mirjam Stahl, Laura Lozza, Ekaterina Tikhonova, Elisa Rosati, Ulrik Stervbo, Nina Babel, Jochen G. Mainz, Hilmar Wisplinghoff, Frank Ebel, Lei-Jie Jia, Matthew G. Blango, Peter Hortschansky, Sascha Brunke, Bernhard Hube, Axel A. Brakhage, Olaf Kniemeyer, Alexander Scheffold, Petra Bacher
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
BACKGROUND The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types of A. fumigatus–specific Th cells in pwCF and their cont
Externí odkaz:
https://doaj.org/article/952a35bb46204b4d99016140937e7c30
Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus
Autor:
Alexander Kühbacher, Mandy Peiffer, Peter Hortschansky, Petra Merschak, Michael J. Bromley, Hubertus Haas, Axel A. Brakhage, Fabio Gsaller
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Aspergillus fumigatus is one of the deadliest fungal species, causing hundreds of thousands of deaths each year. Because azoles provide the preferred first-line option for treatment of aspergillosis, the increase in rates of resistance and t
Externí odkaz:
https://doaj.org/article/b64b3732f24548c5bbb8c2445cb492cc
Autor:
Lukas Page, Julia Wallstabe, Jasmin Lother, Maximilian Bauser, Olaf Kniemeyer, Lea Strobel, Vera Voltersen, Janka Teutschbein, Peter Hortschansky, Charles Oliver Morton, Axel A. Brakhage, Max Topp, Hermann Einsele, Sebastian Wurster, Juergen Loeffler
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Aspergillus fumigatus causes life-threatening opportunistic infections in immunocompromised patients. As therapeutic outcomes of invasive aspergillosis (IA) are often unsatisfactory, the development of targeted immunotherapy remains an important goal
Externí odkaz:
https://doaj.org/article/207287c8a5c445f8b26ff8097c93cc97
Autor:
Ines Hasenbein, André Sachse, Peter Hortschansky, Klaus D. Schmuck, Victoria Horbert, Christoph Anders, Thomas Lehmann, René Huber, Alexander Maslaris, Frank Layher, Christina Braun, Andreas Roth, Frank Plöger, Raimund W. Kinne
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 513 (2022)
Effects of hydroxyapatite (HA) particles with bone morphogenetic BMP-2 or GDF-5 were compared in sheep lumbar osteopenia; in vitro release in phosphate-buffered saline (PBS) or sheep serum was assessed by ELISA. Lumbar (L) vertebral bone defects (Ø
Externí odkaz:
https://doaj.org/article/79ebcc514e4d49fbba037c561a278293
Autor:
Manuel Sánchez López-Berges, Mareike Thea Scheven, Peter Hortschansky, Matthias Misslinger, Clara Baldin, Fabio Gsaller, Ernst R. Werner, Thomas Krüger, Olaf Kniemeyer, Jakob Weber, Axel A. Brakhage, Hubertus Haas
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7739 (2021)
The airborne fungus Aspergillus fumigatus causes opportunistic infections in humans with high mortality rates in immunocompromised patients. Previous work established that the bZIP transcription factor HapX is essential for virulence via adaptation t
Externí odkaz:
https://doaj.org/article/d99ccd7dfd014e79b14fb1b34f7c45ad
Autor:
Matthias Misslinger, Mareike Thea Scheven, Peter Hortschansky, Manuel Sánchez López-Berges, Katharina Heiss, Nicola Beckmann, Thomas Heigl, Martin Hermann, Thomas Krüger, Olaf Kniemeyer, Axel A Brakhage, Hubertus Haas
Publikováno v:
PLoS Genetics, Vol 15, Iss 9, p e1008379 (2019)
Efficient adaptation to iron starvation is an essential virulence determinant of the most common human mold pathogen, Aspergillus fumigatus. Here, we demonstrate that the cytosolic monothiol glutaredoxin GrxD plays an essential role in iron sensing i
Externí odkaz:
https://doaj.org/article/d31ad98d678b4e83bb0839932928c100
Autor:
Vera Voltersen, Matthew G. Blango, Sahra Herrmann, Franziska Schmidt, Thorsten Heinekamp, Maria Strassburger, Thomas Krüger, Petra Bacher, Jasmin Lother, Esther Weiss, Kerstin Hünniger, Hong Liu, Peter Hortschansky, Alexander Scheffold, Jürgen Löffler, Sven Krappmann, Sandor Nietzsche, Oliver Kurzai, Hermann Einsele, Olaf Kniemeyer, Scott G. Filler, Utz Reichard, Axel A. Brakhage
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Aspergillus fumigatus is a common airborne fungal pathogen of humans and a significant source of mortality in immunocompromised individuals. Here, we provide the most extensive cell wall proteome profiling to date of A. fumigatus resting con
Externí odkaz:
https://doaj.org/article/9fe5a0ecbee347959685d1702c23f58a
Autor:
Nanbiao Long, Thomas Orasch, Shizhu Zhang, Lu Gao, Xiaoling Xu, Peter Hortschansky, Jing Ye, Fenli Zhang, Kai Xu, Fabio Gsaller, Maria Straßburger, Ulrike Binder, Thorsten Heinekamp, Axel A Brakhage, Hubertus Haas, Ling Lu
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007762 (2018)
Both branched-chain amino acids (BCAA) and iron are essential nutrients for eukaryotic cells. Previously, the Zn2Cys6-type transcription factor Leu3/LeuB was shown to play a crucial role in regulation of BCAA biosynthesis and nitrogen metabolism in S
Externí odkaz:
https://doaj.org/article/be69d7fd105d4bbb84fc6f1c2324f420
Aspf2 From Aspergillus fumigatus Recruits Human Immune Regulators for Immune Evasion and Cell Damage
Autor:
Prasad Dasari, Iordana A. Shopova, Maria Stroe, Dirk Wartenberg, Hans Martin-Dahse, Niklas Beyersdorf, Peter Hortschansky, Stefanie Dietrich, Zoltán Cseresnyés, Marc Thilo Figge, Martin Westermann, Christine Skerka, Axel A. Brakhage, Peter F. Zipfel
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The opportunistic fungal pathogen Aspergillus fumigatus can cause life-threatening infections, particularly in immunocompromised patients. Most pathogenic microbes control host innate immune responses at the earliest time, already before infiltrating
Externí odkaz:
https://doaj.org/article/66b75f15becf48bea906679d1351830e