Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Peter Hornbeck"'
Publikováno v:
BMC Medical Genomics, Vol 12, Iss S6, Pp 1-10 (2019)
BMC Medical Genomics
BMC Medical Genomics
Background Perturbed posttranslational modification (PTM) landscapes commonly cause pathological phenotypes. The Cancer Genome Atlas (TCGA) project profiles thousands of tumors allowing the identification of spontaneous cancer-driving mutations, whil
SRSF protein kinases 1 and 2 are essential host factors for human coronaviruses including SARS-CoV-2
Autor:
Shankara Anand, Lewis C. Cantley, Long He, Joseph D. Trimarco, Benjamin E. Nilsson-Payant, Edward R. Kastenhuber, Harel Weinstein, Andrew D. Davidson, Maia Kavanagh-Williamson, Elena Piskounova, Anthony Possemato, Tyler Levy, Cait E. Hamele, Xinyu Zhu, Robert E. Schwartz, Benjamin R. tenOever, Kaitlyn N. Burke, John Blenis, Jared L. Johnson, Gina Lee, Kripa Shobana-Ganesh, François Aguet, Sasha Tkachev, Gad Getz, David A. Matthews, Clare M. Smith, Kate J. Heesom, Nicholas S. Heaton, Purushothama Rao Tata, Shuibing Chen, Danielle K. Bulaon, Aleksandra Tata, Ryan R. Chaparian, Peter Hornbeck, Alexander Kerelsky, Katarina M. Liberatore, Tomer M. Yaron, Brook E. Heaton, Marisa N. Mercadante, Benjamin M. Cohen, Alfred T. Harding, Olivier Elemento, Sean A. Beausoleil, Ting-Yu Lin, Tristan X. Jordan
Publikováno v:
bioRxiv
While vaccines are vital for preventing COVID-19 infections, it is critical to develop new therapies to treat patients who become infected. Pharmacological targeting of a host factor required for viral replication can suppress viral spread with a low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8def4c82dbd399ebda8cd6b0c2c056c
https://europepmc.org/articles/PMC7430567/
https://europepmc.org/articles/PMC7430567/
Publikováno v:
Molecular Cancer Research. 16:173-183
The activity of Src family kinases (Src being the prototypical member) is tightly regulated by differential phosphorylation on Tyr416 (positive) and Tyr527 (negative), a duet that reciprocally regulates kinase activity. The latter negative regulation
Autor:
Steven A. Carr, Jill P. Mesirov, Rajesh Raju, Peter Hornbeck, Michael A. Gillette, Rushdy Ahmad, Pablo Tamayo, D. R. Mani, Matthew J. Szucs, Philipp Mertins, Judit Jané-Valbuena, Dominique Forestier, Karsten Krug, Filip Mundt, Bin Zhang, Hasmik Keshishian, Jacob D. Jaffe
Signaling pathways are orchestrated by post-translational modifications (PTMs) such as phosphorylation. However, pathway analysis of PTM data sets generated by mass spectrometry (MS)-based proteomics is typically performed at a gene-centric level bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc117c3e89459e00fac319d697a1e58c
https://europepmc.org/articles/PMC6398202/
https://europepmc.org/articles/PMC6398202/
Autor:
Travis J. Wheeler, Peter Hornbeck, Jon M. Kornhauser, Beth L. Murray, Latham, Bin Zhang, Florian Gnad, Nandhikonda, Alexander Nord, Elzbieta Skrzypek
Publikováno v:
Nucleic Acids Research
For 15 years the mission of PhosphoSitePlus® (PSP, https://www.phosphosite.org) has been to provide comprehensive information and tools for the study of mammalian post-translational modifications (PTMs). The number of unique PTMs in PSP is now more
Publikováno v:
BCB
Multiple sequence alignment (MSA) is a classic problem in computational genomics. In typical use, MSA software is expected to align a collection of homologous genes, such as orthologs from multiple species or duplication-induced paralogs within a spe
Autor:
Mark L. Grimes, William Cook, Avi Ma'ayan, Lauren Foltz, Travis J. Wheeler, Peter Hornbeck, Alexander Lachmann, Bin Zhang, Ekaterina Smirnova, Klarisa Rikova, Tyler Levy, Michael J. Comb, Neil R. Clark, Jeremiah Gaiser, Benjamin Hall
Publikováno v:
Grimes, M, Hall, B, Foltz, L, Levy, T, Rikova, K, Gaiser, J, Cook, W, Smirnova, E, Wheeler, T, Clark, N R, Lachmann, A, Zhang, B, Hornbeck, P, Ma’ayan, A & Comb, M 2018, ' Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks ', Science Signaling, vol. 11, no. 531, pp. eaaq1087 . https://doi.org/10.1126/scisignal.aaq1087
Protein posttranslational modifications (PTMs) have typically been studied independently, yet many proteins are modified by more than one PTM type, and cell signaling pathways somehow integrate this information. We coupled immunoprecipitation using P
Autor:
Adam G. Sowalsky, Sushil Kumar, Raymond B. Birge, Peter Hornbeck, Leszek Kotula, Sajjad Hossain, Updesh Dixit, Yongzhang Liu, Weiming Zheng, Jing Li, Bin Lu
Publikováno v:
Oncotarget
// Sushil Kumar 1 , Bin Lu 2,3 , Updesh Dixit 1 , Sajjad Hossain 4 , Yongzhang Liu 2 , Jing Li 5 , Peter Hornbeck 5 , Weiming Zheng 6 , Adam G. Sowalsky 7 , Leszek Kotula 4 and Raymond B. Birge 1 1 Department of Microbiology, Biochemistry and Molecul
Autor:
Peter Hornbeck, Jon M. Kornhauser, Elzbieta Skrzypek, Vaughan Latham, Beth L. Murray, Bin Zhang
Publikováno v:
Nucleic Acids Research
PhosphoSitePlus(®) (PSP, http://www.phosphosite.org/), a knowledgebase dedicated to mammalian post-translational modifications (PTMs), contains over 330,000 non-redundant PTMs, including phospho, acetyl, ubiquityl and methyl groups. Over 95% of the
Autor:
Kazuya Machida, Wojciech Jankowski, Canan Kasikara, Tong Liu, Raymond B. Birge, Jing Li, Hong Li, Khanh-Quynh N. Nguyen, Charalampos G. Kalodimos, Charles Reichman, Peter Hornbeck, Ganapathy Sriram, Tamjeed Saleh
Publikováno v:
Oncogene
Crk, the prototypical member of a class of Src homology-2 (SH2) and Src homology-3 (SH3) domain containing proteins that controls the coordinated assembly of signaling complexes, is regulated by phosphorylation of Y221 in the linker region, which for