Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Peter Holland-Fischer"'
Autor:
Moises Alberto Suarez-Zdunek, Nicoline Stender Arentoft, Paul Suno Krohn, Emilie Høegholm Ernst Lauridsen, Shoaib Afzal, Julie Høgh, Magda Teresa Thomsen, Andreas Dehlbæk Knudsen, Børge Grønne Nordestgaard, Jens Georg Hillingsø, Gerda Elisabeth Villadsen, Peter Holland-Fischer, Allan Rasmussen, Anette Dam Fialla, Ulla Feldt-Rasmussen, Susanne D. Nielsen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The prevalence of hyperthyroidism and hypothyroidism and associated risk factors are unknown in liver transplant recipients. We aimed to determine the prevalence of hyperthyroidism and hypothyroidism and associated risk factors in liver tran
Externí odkaz:
https://doaj.org/article/0b4e87725eb24d828657b0196835d2c0
Autor:
Magda Teresa Thomsen, Julie Høgh, Andreas Dehlbæk Knudsen, Anne Marie Reimer Jensen, Marco Gelpi, Gerda E. Villadsen, Rozeta Abazi, Peter Holland-Fischer, Lars Køber, Otto Clemmesen, Paul Suno Krohn, Jens Hillingsø, Tina Vilsbøll, Tor Biering-Sørensen, Klaus Fuglsang Kofoed, Børge Grønne Nordestgaard, Allan Rasmussen, Susanne Dam Nielsen
Publikováno v:
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Liver transplantation is the only curative treatment for patients with end-stage liver disease. Short-term survival has improved due to improved surgical techniques and greater efficacy of immunosuppressive drugs. However, long-te
Externí odkaz:
https://doaj.org/article/0684212c407e437bb23696d406ee45e2
Autor:
David Haldrup, Chunshan Wei, Peter Holland-Fischer, Kurt Kristensen, Søren Rittig, Aksel Lange, Arne Hørlyck, Jan Solvig, Henning Grønbæk, Niels H. Birkebæk, Jan Frystyk
Publikováno v:
Haldrup, D, Wei, C, Holland-Fischer, P, Kristensen, K, Rittig, S, Lange, A, Hørlyck, A, Solvig, J, Grønbæk, H, Birkebæk, N H & Frystyk, J 2023, ' Effects of lifestyle intervention on IGF-1, IGFBP-3, and insulin resistance in children with obesity with or without metabolic-associated fatty liver disease ', European Journal of Pediatrics, vol. 182, no. 2, pp. 855-865 . https://doi.org/10.1007/s00431-022-04731-1
Haldrup, D, Wei, C, Holland-Fischer, P, Kristensen, K, Rittig, S, Lange, A, Hørlyck, A, Solvig, J, Grønbæk, H, Birkebæk, N H & Frystyk, J 2023, ' Effects of lifestyle intervention on IGF-1, IGFBP-3, and insulin resistance in children with obesity with or without metabolic-associated fatty liver disease ', European Journal of Pediatrics, vol. 182, no. 2, pp. 855–865 . https://doi.org/10.1007/s00431-022-04731-1
Haldrup, D, Wei, C, Holland-Fischer, P, Kristensen, K, Rittig, S, Lange, A, Hørlyck, A, Solvig, J, Grønbæk, H, Birkebæk, N H & Frystyk, J 2023, ' Effects of lifestyle intervention on IGF-1, IGFBP-3, and insulin resistance in children with obesity with or without metabolic-associated fatty liver disease ', European Journal of Pediatrics, vol. 182, no. 2, pp. 855–865 . https://doi.org/10.1007/s00431-022-04731-1
Obesity is a strong predictor for metabolic associated fatty liver disease (MAFLD), which has been associated with decreased insulin like growth factor 1 (IGF-1). In obesity, weight loss increases growth hormone secretion, but this is not unequivocal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2497f771028880043b9612bbf5a24ba0
https://vbn.aau.dk/da/publications/095b7c3d-4282-4b21-86b1-7bf8c1894fc3
https://vbn.aau.dk/da/publications/095b7c3d-4282-4b21-86b1-7bf8c1894fc3
Autor:
Kamilla, Steensig, Manan, Pareek, Anne Lund, Krarup, Peter, Sogaard, Michael, Maeng, Bhupendar, Tayal, Christina Ji-Young, Lee, Christian, Torp-Pedersen, Gregory Yh, Lip, Peter, Holland-Fischer, Kristian Hay, Kragholm
Publikováno v:
Clinics and research in hepatology and gastroenterology. 46(8)
Balancing the risk of thromboembolism and bleeding in patients with liver disease and atrial fibrillation/flutter is particularly challenging.To examine the risks of thromboembolism and bleeding with use/non-use of oral anticoagulation (including vit
Publikováno v:
Kazankov, K, Holland-Fischer, P, Thomsen, K L, Jalan, R & Mookerjee, R 2022, ' Bilirubin and its dynamics are independently associated with mortality in patients with acute decompensation of cirrhosis ', Journal of Hepatology, vol. 77, no. Suppl. 1, THU503, pp. S344 . https://doi.org/10.1016/S0168-8278(22)01050-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf8abf34818700b0f7e64c5fdbdebc7
https://vbn.aau.dk/da/publications/2f311e53-834f-4e49-968d-cfc2ef8a064a
https://vbn.aau.dk/da/publications/2f311e53-834f-4e49-968d-cfc2ef8a064a
Autor:
Marco Gelpi, Allan Rasmussen, Peter Holland-Fischer, Jens Hillingsø, Anne Marie Jensen, Tina Vilsbøll, Tor Biering-Sørensen, Magda Teresa Thomsen, Lars Køber, Otto Clemmesen, Børge G. Nordestgaard, Rozeta Abazi, Gerda Elisabeth Villadsen, Paul Suno Krohn, Julie Høgh, Klaus F. Kofoed, Susanne Dam Nielsen, Andreas Knudsen
Publikováno v:
Thomsen, M T, Høgh, J, Knudsen, A D, Jensen, A M R, Gelpi, M, Villadsen, G E, Abazi, R, Holland-Fischer, P, Køber, L, Clemmesen, O, Krohn, P S, Hillingsø, J, Vilsbøll, T, Biering-Sørensen, T, Kofoed, K F, Nordestgaard, B G, Rasmussen, A & Nielsen, S D 2021, ' The Danish comorbidity in liver transplant recipients study (DACOLT) : a non-interventional prospective observational cohort study ', BMC Gastroenterology, vol. 21, 145 . https://doi.org/10.1186/s12876-021-01733-5
Thomsen, M T, Høgh, J, Knudsen, A D, Jensen, A M R, Gelpi, M, Villadsen, G E, Abazi, R, Holland-Fischer, P, Køber, L, Clemmesen, O, Krohn, P S, Hillingsø, J, Vilsbøll, T, Biering-Sørensen, T, Kofoed, K F, Nordestgaard, B G, Rasmussen, A & Nielsen, S D 2021, ' The Danish comorbidity in liver transplant recipients study (DACOLT) : a non-interventional prospective observational cohort study ', BMC Gastroenterology, vol. 21, no. 1, 145 . https://doi.org/10.1186/s12876-021-01733-5
Thomsen, M T, Høgh, J, Knudsen, A D, Jensen, A M R, Gelpi, M, Villadsen, G E, Abazi, R, Holland-fischer, P, Køber, L, Clemmesen, O, Krohn, P S, Hillingsø, J, Vilsbøll, T, Biering-sørensen, T, Kofoed, K F, Nordestgaard, B G, Rasmussen, A & Nielsen, S D 2021, ' The Danish comorbidity in liver transplant recipients study (DACOLT) : a non-interventional prospective observational cohort study ', BMC Gastroenterology, vol. 21, no. 1 . https://doi.org/10.1186/s12876-021-01733-5
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Gastroenterology
Thomsen, M T, Høgh, J, Knudsen, A D, Jensen, A M R, Gelpi, M, Villadsen, G E, Abazi, R, Holland-Fischer, P, Køber, L, Clemmesen, O, Krohn, P S, Hillingsø, J, Vilsbøll, T, Biering-Sørensen, T, Kofoed, K F, Nordestgaard, B G, Rasmussen, A & Nielsen, S D 2021, ' The Danish comorbidity in liver transplant recipients study (DACOLT) : a non-interventional prospective observational cohort study ', BMC Gastroenterology, vol. 21, no. 1, 145 . https://doi.org/10.1186/s12876-021-01733-5
Thomsen, M T, Høgh, J, Knudsen, A D, Jensen, A M R, Gelpi, M, Villadsen, G E, Abazi, R, Holland-fischer, P, Køber, L, Clemmesen, O, Krohn, P S, Hillingsø, J, Vilsbøll, T, Biering-sørensen, T, Kofoed, K F, Nordestgaard, B G, Rasmussen, A & Nielsen, S D 2021, ' The Danish comorbidity in liver transplant recipients study (DACOLT) : a non-interventional prospective observational cohort study ', BMC Gastroenterology, vol. 21, no. 1 . https://doi.org/10.1186/s12876-021-01733-5
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Gastroenterology
Background Liver transplantation is the only curative treatment for patients with end-stage liver disease. Short-term survival has improved due to improved surgical techniques and greater efficacy of immunosuppressive drugs. However, long-term surviv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f2c7c3056b1b1b47d57a3b4b7b543a
https://findresearcher.sdu.dk:8443/ws/files/181756149/s12876_021_01733_5.pdf
https://findresearcher.sdu.dk:8443/ws/files/181756149/s12876_021_01733_5.pdf
Autor:
Zobair M Younossi, Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M Anstee, Zachary Goodman, Pierre Bedossa, Andreas Geier, Susanne Beckebaum, Philip N Newsome, David Sheridan, Muhammad Y Sheikh, James Trotter, Whitfield Knapple, Eric Lawitz, Manal F Abdelmalek, Kris V Kowdley, Aldo J Montano-Loza, Jerome Boursier, Philippe Mathurin, Elisabetta Bugianesi, Giuseppe Mazzella, Antonio Olveira, Helena Cortez-Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean-Francois Dufour, David Shapiro, Jason Campagna, Luna Zaru, Leigh MacConell, Reshma Shringarpure, Stephen Harrison, Arun J Sanyal, Manal Abdelmalek, Gary Abrams, Humberto Aguilar, Aijaz Ahmed, Elmar Aigner, Guruprasad Aithal, Aftab Ala, William Alazawi, Agustin Albillos, Michael Allison, Sfa Al-Shamma, Raul Andrade, Pietro Andreone, Mario Angelico, Victor Ankoma-Sey, Quentin Anstee, Rodolphe Anty, Victor Araya, Juan Ignacio Arenas Ruiz, Perttu Arkkila, Marty Arora, Tarik Asselah, Jennifer Au, Oyekoya Ayonrinde, Robert James Bailey, Maya Balakrishnan, Kiran Bambha, Meena Bansal, Sidney Barritt, John Bate, Jorge Beato, Jaideep Behari, Pablo Bellot, Ziv Ben Ari, Michael Bennett, Marina Berenguer, Benedetta Terziroli Beretta-Piccoli, Thomas Berg, Maurizio Bonacini, Lucia Bonet, Brian Borg, Marc Bourliere, William Bowman, David Bradley, Marija Brankovic, Marius Braun, Jean-Pierre Bronowicki, Savino Bruno, Cindy Cai, Amy Calderon, José Luis Calleja Panero, Elizabeth Carey, Michal Carmiel, Jose Antonio Carrión, Matthew Cave, Cristina Chagas, Tawfik Chami, Alan Chang, Allan Coates, Jeremy Cobbold, Charlote Costentin, Kathleen Corey, Lynsey Corless, Javier Crespo, Oscar Cruz Pereira, Victor de Ledinghen, Andrew deLemos, Moises Diago, Mamie Dong, Jean-François Dufour, Predrag Dugalic, Winston Dunn, Magby Elkhashab, Michael Epstein, Maria Desamparados Escudero-Garcia, Ohad Etzion, Larry Evans, Robert Falcone, Conrado Fernandez, Jose Ferreira, Scott Fink, Kevin Finnegan, Roberto Firpi-Morell, Annarosa Floreani, Thierry Fontanges, Ryan Ford, Ewan Forrest, Andrew Fowell, Anna Ludovica Fracanzani, Sven Francque, Bradley Freilich, Juan Frias, Michael Fuchs, Javier Fuentes, Michael Galambos, Juan Gallegos, Anja Geerts, Jacob George, Maged Ghali, Reem Ghalib, Pierre Gholam, Pere Gines, Norman Gitlin, Tobias Goeser, John Goff, Stuart Gordon, Frederic Gordon, Odile Goria, Shaun Greer, Alla Grigorian, Henning Gronbaek, Maeva Guillaume, Naresh Gunaratnam, Dina Halegoua-De Marzio, Bilal Hameed, Stephanie Hametner, James Hamilton, Marek Hartleb, Tarek Hassanein, Dieter Häussinger, Paul Hellstern, Robert Herring, Eva Heurich, Christophe Hezode, Holger Hinrichsen, Peter Holland Fischer, Yves Horsmans, Jonathan Huang, Hyder Hussaini, Antoine Jakiche, Lennox Jeffers, Blake Jones, Rosa Jorge, Francisco Jorquera, Shoba Joshi, Alisan Kahraman, Kelly Kaita, Nicholas Karyotakis, Zeid Kayali, Stergios Kechagias, Thomas Kepczyk, Mandana Khalili, Hicham Khallafi, Johannes Kluwe, Anita Kohli, Kevin Korenblat, Kris Kowdley, Aleksander Krag, Richard Krause, Andreas Kremer, Karen Krok, Miodrag Krstic, Marcelo Kugelmas, Sonal Kumar, Scott Kuwada, Damien Labarriere, Michelle Lai, Wim Laleman, Pietro Lampertico, Alice Lee, Vincent Leroy, Steven Lidofsky, Tina Huey Lim, Joseph Lim, Donald Lipkis, Ester Little, Amadeo Lonardo, Michelle Long, Velimir Anthony Christopher Luketic, Yoav Lurie, Guilherme Macedo, Joana Magalhaes, Mihály Makara, Benedict Maliakkal, Michael Manns, Pinelopi Manousou, Parvez Mantry, Giulio Marchesini, Carla Marinho, Paul Marotta, Hanns-Ulrich Marschall, Linda Martinez, Marlyn Mayo, Mark McCullen, William McLaughlin, Uta Merle, Raphael Merriman, Apurva Modi, Esther Molina, Aldo Montano-Loza, Carlos Monteverde, Amilcar Morales Cardona, Sulleman Moreea, Christophe Moreno, Filomena Morisco, Abdullah Mubarak, Beat Muellhaupt, Sandeep Mukherjee, Tobias Müller, Aleksandar Nagorni, Jahnavi Naik, Guy Neff, Moises Nevah, Philip Newsome, Eric Nguyen-Khac, Mazen Noureddin, Jude Oben, Hans Orlent, James Orr, Grisell Ortiz-Lasanta, Violaine Ozenne, Prashant Pandya, Angelo Paredes, James Park, Joykumar Patel, Keyur Patel, Sonali Paul, Heather Patton, Markus Peck-Radosavljevic, Salvatore Petta, Stephen Pianko, Anna Piekarska, Neville Pimstone, Joseph Pisegna, Paul Pockros, Stanislas Pol, Michael Porayko, John Poulos, David Pound, Joe Pouzar, Jose Presa Ramos, Nikolaos Pyrsopoulos, Nila Rafiq, Kate Muller, Alnoor Ramji, Ravi Ravinuthala, Chakradhar Reddy, Gautham Reddy K G, K. Rajender Reddy K R, Frederic Regenstein, Robert Reindollar, Justin Reynolds, Andres Riera, Jose Rivera Acosta, Geert Robaeys, Stuart Roberts, Federico Rodriguez-Perez, Sandor Romero, Manuel Romero-Gomez, Raymond Rubin, Mariagrazia Rumi, Simon Rushbrook, Christian Rust, Michael Ryan, Rifaat Safadi, Adnan Said, Kimmo Salminen, Didier Samuel, John Santoro, Arun Sanyal, Souvik Sarkar, Cynthia Schaeffer, Jörn Schattenberg, Ingolf Schiefke, Eugene Schiff, Wolfgang Schmidt, Jeffrey Schneider, Jeoffrey Schouten, Michael Schultz, Giada Sebastiani, David Semela, Thomas Sepe, Aasim Sheikh, Muhammad Sheikh, Kenneth Sherman, Oren Shibolet, Mitchell Shiffman, Asma Siddique, Cyril Sieberhagen, Samuel Sigal, Katarzyna Sikorska, Krzysztof Simon, Marie Sinclair, Richard Skoien, Joel Solis, Siddharth Sood, Bob Souder, James Spivey, Per Stal, Laura Stinton, Simone Strasser, Petar Svorcan, Gyongzi Szabo, Andrew Talal, Edward Tam, Brent Tetri, Paul Thuluvath, Hillel Tobias, Krzysztof Tomasiewicz, Dawn Torres, Albert Tran, Michael Trauner, Christian Trautwein, Emanuel Tsochatzis, Esther Unitt, Victor Vargas, Istvan Varkonyi, Ella Veitsman, Umberto Vespasiani Gentilucci, David Victor, John Vierling, Catherine Vincent, Aron Vincze, Manfred von der Ohe, Natasha Von Roenn, Raj Vuppalanchi, Michael Waters, Kymberly Watt, Julia Wattacheril, Martin Weltman, Amanda Wieland, Gregory Wiener, Alonzo Williams A, Jeffrey Williams J, Jason Wilson, Maria Yataco, Eric Yoshida, Ziad Younes, Liyun Yuan, Adam Zivony, Donald Zogg, Heinz Zoller, Fabien Zoulim, Eli Zuckerman, Massimo Zuin
Publikováno v:
REGENERATE Study Investigators 2019, ' Obeticholic acid for the treatment of non-alcoholic steatohepatitis : interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial ', The Lancet, vol. 394, no. 10215, pp. 2184-2196 . https://doi.org/10.1016/S0140-6736(19)33041-7
The lancet : international edition
Younossi, Z M, Ratziu, V, Loomba, R, Rinella, M, Anstee, Q M, Goodman, Z, Bedossa, P, Geier, A, Beckebaum, S, Newsome, P N, Sheridan, D, Sheikh, M Y, Trotter, J, Knapple, W, Lawitz, E, Abdelmalek, M F, Kowdley, K V, Montano-Loza, A J, Boursier, J, Mathurin, P, Bugianesi, E, Mazzella, G, Olveira, A, Cortez-Pinto, H, Graupera, I, Orr, D, Gluud, L L, Dufour, J-F, Shapiro, D, Campagna, J, Zaru, L, MacConell, L, Shringarpure, R, Harrison, S, Sanyal, A J & REGENERATE Study Investigators 2019, ' Obeticholic acid for the treatment of non-alcoholic steatohepatitis : interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial ', The Lancet, vol. 394, no. 10215, pp. 2184-2196 . https://doi.org/10.1016/S0140-6736(19)33041-7
The lancet : international edition
Younossi, Z M, Ratziu, V, Loomba, R, Rinella, M, Anstee, Q M, Goodman, Z, Bedossa, P, Geier, A, Beckebaum, S, Newsome, P N, Sheridan, D, Sheikh, M Y, Trotter, J, Knapple, W, Lawitz, E, Abdelmalek, M F, Kowdley, K V, Montano-Loza, A J, Boursier, J, Mathurin, P, Bugianesi, E, Mazzella, G, Olveira, A, Cortez-Pinto, H, Graupera, I, Orr, D, Gluud, L L, Dufour, J-F, Shapiro, D, Campagna, J, Zaru, L, MacConell, L, Shringarpure, R, Harrison, S, Sanyal, A J & REGENERATE Study Investigators 2019, ' Obeticholic acid for the treatment of non-alcoholic steatohepatitis : interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial ', The Lancet, vol. 394, no. 10215, pp. 2184-2196 . https://doi.org/10.1016/S0140-6736(19)33041-7
© 2019 Elsevier Ltd. All rights reserved.
Background: Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the his
Background: Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b4774824d4fc96584556df1079fe77
Autor:
Banwari Agarwal, Rohit Sawhney, Peter Holland-Fischer, Rajiv Jalan, M. Rosselli, Rajeshwar P. Mookerjee
Publikováno v:
Liver Transplantation. 22:732-742
Hepatic encephalopathy (HE) is a common feature of acute-on-chronic liver failure (ACLF). Although ammonia, inflammation, and cerebral oxygenation are associated with HE in acute liver failure, their roles in ACLF are unknown. The aim of this prospec
Autor:
Holger Jon Møller, Rajiv Jalan, Rajeshwar P. Mookerjee, Brian R. Davidson, Francis P. Robertson, Henning Grønbæk, Karen Louise Thomsen, Peter Holland-Fischer
Publikováno v:
J Clin Exp Hepatol
Thomsen, K L, Robertson, F P, Holland-Fischer, P, Davidson, B R, Mookerjee, R P, Møller, H J, Jalan, R & Grønbæk, H 2019, ' The Macrophage Activation Marker Soluble CD163 is Associated With Early Allograft Dysfunction After Liver Transplantation ', Journal of Clinical and Experimental Hepatology, vol. 9, no. 3, pp. 302-311 . https://doi.org/10.1016/j.jceh.2018.09.006
Thomsen, K L, Robertson, F P, Holland-Fischer, P, Davidson, B R, Mookerjee, R P, Møller, H J, Jalan, R & Grønbæk, H 2019, ' The Macrophage Activation Marker Soluble CD163 is Associated With Early Allograft Dysfunction After Liver Transplantation ', Journal of Clinical and Experimental Hepatology, vol. 9, no. 3, pp. 302-311 . https://doi.org/10.1016/j.jceh.2018.09.006
Background/Objectives: Soluble CD163 (sCD163), a macrophage activation marker, is upregulated in conditions of macrophage proliferation and activation. Elevated sCD163 levels have been associated with liver disease severity and progression. During li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ded870a29d9493537eef01733ab669f
https://europepmc.org/articles/PMC6637071/
https://europepmc.org/articles/PMC6637071/
Autor:
Rohit Sawhney, Guruprasad P. Aithal, Daniel M. Forton, S. Spinella, N Shah, Nathan Davies, K. Nash, S. Masson, Graham R. Foster, Rajiv Jalan, G. Privitera, Richard Aspinall, R.P. Mookerjee, Peter Holland-Fischer
Publikováno v:
Holland-Fischer, P, Shah, N S M, Sawhney, R, Privitera, G, Spinella, S, Masson, S, Gastier-Foster, J, Aithal, G, Nash, K, Forton, D, Aspinall, R, Davies, N, Jalan, R & Mookerjee, R P 2017, ' DASIMAR: a novel prognostic biomarker for acute cirrhosis decompensation to guide early intervention : a prospective multicenter study ', Journal of Hepatology, vol. 66, no. 1, SAT-022, pp. S567 . < http://www.sciencedirect.com/science/journal/01688278/66/1/supp/S?sdc=1 >
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27083b0b77c2a429c46091ebfe9f84cd
https://vbn.aau.dk/da/publications/9d8729a1-b143-4e50-9bed-a86ae75e6783
https://vbn.aau.dk/da/publications/9d8729a1-b143-4e50-9bed-a86ae75e6783