Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Peter Hewitt"'
Autor:
Natalie Page, Vignesh Karthikaisamy, Darren O'Hara, Aaron N. Cranston, Colin R. O'Dowd, Xavier Jacq, Richard Wilkinson, Stephanie Burton, Hayley Gibson, Joana Costa, Daniel Longley, Matthew Helm, Chris McGivern, Steven Shepherd, Christina Bell, Peter Hewitt, Mary McFarland, Hugues Miel, Steven Whitehead, Lauren Proctor, Shane J. Rountree, Mark Wappett, Mauricio Berriel Diaz, Stephan Herzig, Timothy Harrison
Publikováno v:
Cancer Research. 83:LB022-LB022
Cancer cachexia is a metabolic wasting syndrome characterized by weight loss, anorexia and anemia as a result of tumor burden, and affects up to 80% of advanced cancer patients #1. Cachexia is particularly prevalent in pancreatic, lung, colorectal an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5ec75cf5c267c11f4c7cd1f3093782
https://doi.org/10.1158/1538-7445.am2023-lb022
https://doi.org/10.1158/1538-7445.am2023-lb022
Publikováno v:
Tunnelling and Underground Space Technology. 123:104429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af7cce21d5fe2139fbc8c62162e960ae
https://doi.org/10.1016/j.tust.2022.104429
https://doi.org/10.1016/j.tust.2022.104429
Autor:
Peter Hewitt
Publikováno v:
Performance Research. 21:122-130
What is the relationship between language and the world it supposedly depicts? Is it possible to establish a straightforward correspondence between language and language independent facts, or does language in some way shape the way in which we see th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9efd6825599fb3a40d8afa3bfe1f4441
https://doi.org/10.1080/13528165.2016.1192885
https://doi.org/10.1080/13528165.2016.1192885
Autor:
Eamon Cassidy, Peter Hewitt, Elias Arkoudis, Natalie Page, Gerald Gavory, Hugues Miel, J. S. Shane Rountree, Caroline Hughes, Ewa Odrzywol, Keeva McClelland, Matthew Helm, Colin O'Dowd, Scarlett Dvorkin, Tim Harrison, Linda Jordan, Oliver Barker, Stephanie Feutren-Burton, Ewelina Rozycka, Jakub T. Flasz
Publikováno v:
O'Dowd, C R, Helm, M D, Rountree, J S S, Flasz, J T, Arkoudis, E, Miel, H, Hewitt, P R, Jordan, L, Barker, O, Hughes, C, Rozycka, E, Cassidy, E, McClelland, K, Odrzywol, E, Page, N, Fuetren-Burton, S, Dvorkin, S, Gavory, G & Harrison, T 2018, ' Identification and structure-guided development of pyrimidinone based USP7 inhibitors ', ACS Medicinal Chemistry Letters, vol. 9, no. 3, pp. 238-243 . https://doi.org/10.1021/acsmedchemlett.7b00512
[Image: see text] Ubiquitin specific protease 7 (USP7, HAUSP) has become an attractive target in drug discovery due to the role it plays in modulating Mdm2 levels and consequently p53. Increasing interest in USP7 is emerging due to its potential invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f42201b193e5dbba8db4243fe20048
https://pubmed.ncbi.nlm.nih.gov/29541367
https://pubmed.ncbi.nlm.nih.gov/29541367
Autor:
Ewelina Rozycka, Stephanie Burton, Natalie Page, Christina Bell, Steven Whitehead, Matthew Helm, Colin O'Dowd, Oliver Barker, Frank Burkamp, Steven Shepherd, Gerald Gavory, Eamon Cassidy, Shane Rountree, Tim Harrison, Peter Hewitt, Xavier Jacq, Mark Wappett
Publikováno v:
Cancer Research. 79:LB-049
The current interest in protein homeostasis as a therapeutic strategy has highlighted the importance of protein ubiquitination as a post-translational modification. Protein degradation has been enabled by several approaches (e.g. small molecule degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b335541ffa3408590a07af3c2fc2b81e
https://doi.org/10.1158/1538-7445.am2019-lb-049
https://doi.org/10.1158/1538-7445.am2019-lb-049
Autor:
Colin O'Dowd, Caroline Hughes, Mary McFarland, Peter Hewitt, Nathalie Bedard, Xavier Jacq, Mark Wappett, Rachel Church, Aaron Cranston, Hugues Miel, Ewelina Rozycka, Eamon Cassidy, Oliver Baker, Simon S. Wing, Ashling Henderson, Christina Bell, Shane Roundtree, Matthew Helm, Stephanie Burton, Joana Costa, Gerald Gavory, Tim Harrison, Lauren Proctor, Steven Whitehead
Publikováno v:
Cancer Research. 79:LB-087
Over the past decade, protein ubiquitination has emerged as an important post-translational modification with regulatory functions in all important cellular processes. Deubiquitinating enzymes (DUBs) including ubiquitin specific proteases (USPs) cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84225a1d29500dc055e4d41bb2e148af
https://doi.org/10.1158/1538-7445.am2019-lb-087
https://doi.org/10.1158/1538-7445.am2019-lb-087
Publikováno v:
British Journal of Occupational Therapy. 76:355-361
Introduction: Young-onset dementia affects about 1 in 1500 people aged under 65 years in the United Kingdom (UK). It is associated with loss of employment, independence and an increase in psychological distress. This project set out to identify the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a465a4dbbf3be64e413e14fc7db933
https://doi.org/10.4276/030802213x13757040168270
https://doi.org/10.4276/030802213x13757040168270
Autor:
Colin O'Dowd, Adam Treder, Eamon Cassidy, Joana Costa, Christina Bell, Ashling Henderson, Gerald Gavory, Oliver Barker, Ewelina Rozycka, Matt Helm, Timothy Harrison, Natalie Page, Frank Burkamp, Mary McFarland, Anthony Dossang, Mark Wappett, Steven Shepherd, Hugues Miel, Peter Hewitt, Stephanie Burton, Caroline Hughes, Shane Rountree, Lauren Proctor, Steven Whitehead
Publikováno v:
Cancer Research. 78:1935-1935
Over the past decade, protein ubiquitination has emerged as an important post-translational modification with regulatory functions in all important cellular processes. Deubiquitinating enzymes (DUBs) including ubiquitin specific proteases (USPs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aadcc8acfb17ff79c7e20112a76d2c81
https://doi.org/10.1158/1538-7445.am2018-1935
https://doi.org/10.1158/1538-7445.am2018-1935
Autor:
Ewelina Rozycka, Oliver Barker, Joana Costa, Ashling Henderson, Caroline Hughes, Peter Hewitt, Gerald Gavory, Tim Harrison, Anthony Dossang, Colin O'Dowd, Mary McFarland, Lauren Proctor, Hugues Miel
Publikováno v:
Cancer Research. 77:1181-1181
Over the past decade, protein ubiquitination has emerged as an important post-translational modification with regulatory functions in all important cellular processes. Deubiquitinating enzymes (DUBs) including ubiquitin specific proteases (USPs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81e68da27c8aa7f5976ab157b48cef2e
https://doi.org/10.1158/1538-7445.am2017-1181
https://doi.org/10.1158/1538-7445.am2017-1181
Autor:
Christensen, Peter Hewitt
The dissertation examines the production of knowledge and architecture through the German-sponsored construction of the Ottoman railway network, comprising four discrete projects: the railways of European Turkey, the Anatolian railways, the Baghdad r
Externí odkaz:
http://dissertations.umi.com/gsas.harvard:11375
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274597
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274597
