Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Peter Heukels"'
Autor:
Lysanne A. Lievense, MD, PhD, Peter Heukels, MD, PhD, Nico C. van Walree, MD, Cor H. van der Leest, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 1, Pp 100441- (2023)
Introduction: Immune checkpoint inhibition (ICI) is an important treatment modality in metastatic NSCLC and management of immunotherapy-related adverse effects (irAEs) can be challenging. Retreatment after discontinuation of ICI because of irAEs is a
Externí odkaz:
https://doaj.org/article/3dd65decf6dd4073a810a737dd461e0d
Autor:
Peter Heukels, Jennifer A. C. van Hulst, Menno van Nimwegen, Carian E. Boorsma, Barbro N. Melgert, Jan H. von der Thusen, Bernt van den Blink, Rogier A. S. Hoek, Jelle R. Miedema, Stefan F. H. Neys, Odilia B. J. Corneth, Rudi W. Hendriks, Marlies S. Wijsenbeek, Mirjam Kool
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Rationale Idiopathic Pulmonary Fibrosis (IPF) is thought to be triggered by repeated alveolar epithelial cell injury. Current evidence suggests that aberrant immune activation may contribute. However, the role of B-cell activation remains un
Externí odkaz:
https://doaj.org/article/13715e292aad4ffcbe1f2d8589b1faa4
Aberrant B Cell Receptor Signaling in Naïve B Cells from Patients with Idiopathic Pulmonary Fibrosis
Autor:
Stefan F. H. Neys, Peter Heukels, Jennifer A. C. van Hulst, Jasper Rip, Marlies S. Wijsenbeek, Rudi W. Hendriks, Odilia B. J. Corneth
Publikováno v:
Cells, Vol 10, Iss 6, p 1321 (2021)
Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease in which an impaired healing response to recurrent micro-injuries is thought to lead to fibrosis. Recent findings hint at a role for B cells and autoimmunity in IPF pathoge
Externí odkaz:
https://doaj.org/article/fa45eff5b9444030877a295a4126064e
Publikováno v:
Frontiers in Medicine, Vol 4 (2017)
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease which has a major impact on patients’ quality of life (QOL). Except for lung transplantation, there is no curative treatment option. Fortunately, two disease-modifyin
Externí odkaz:
https://doaj.org/article/4733b114a56d48adb89fb9ef8c2474db
Publikováno v:
JTO clinical and research reports. 4(1)
Immune checkpoint inhibition (ICI) is an important treatment modality in metastatic NSCLC and management of immunotherapy-related adverse effects (irAEs) can be challenging. Retreatment after discontinuation of ICI because of irAEs is a frequent clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec573d38f685385a14b9c5bbd76bf926
https://pubmed.ncbi.nlm.nih.gov/36578272
https://pubmed.ncbi.nlm.nih.gov/36578272
Autor:
Peter Heukels, Mirjam Kool, Rudi W. Hendriks, Leon M. van den Toorn, Marlies S. Wijsenbeek, K. A. Boomars, Jennifer A C van Hulst, Odilia B. J. Corneth, Annemien E. van den Bosch, Denise van Uden
Publikováno v:
Thorax, 76(12), 1209-1218. BMJ Publishing Group
Thorax
Thorax
IntroductionAutoreactivity against pulmonary vascular structures is thought to be involved in idiopathic pulmonary arterial hypertension (IPAH), but the underlying mechanisms remain poorly understood. We hypothesised that aberrant B-cell activation c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c2f4418e6b11fb4f5d512ce6b8f8f6
https://pure.eur.nl/en/publications/4c4cdc2f-8a87-4ba3-a6af-29db99265b02
https://pure.eur.nl/en/publications/4c4cdc2f-8a87-4ba3-a6af-29db99265b02
Autor:
Marlies S. Wijsenbeek, Odilia B. J. Corneth, Menno van Nimwegen, Barbro N. Melgert, Carian E. Boorsma, Stefan F H Neys, Mirjam Kool, Jan H. von der Thüsen, Rogier A.S. Hoek, Bernt van den Blink, Jennifer A C van Hulst, Jelle R. Miedema, Peter Heukels, Rudi W. Hendriks
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019)
Respiratory Research
Respiratory Research, 20(1):232. BioMed Central Ltd.
Respiratory Research
Respiratory Research, 20(1):232. BioMed Central Ltd.
Rationale Idiopathic Pulmonary Fibrosis (IPF) is thought to be triggered by repeated alveolar epithelial cell injury. Current evidence suggests that aberrant immune activation may contribute. However, the role of B-cell activation remains unclear. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b99b5f70c72f54b212d5e175859d105
http://link.springer.com/article/10.1186/s12931-019-1195-7
http://link.springer.com/article/10.1186/s12931-019-1195-7
Publikováno v:
Respiratory Medicine, 147, 79-91. W.B. Saunders
Idiopathic pulmonary fibrosis (IPF) is a progressive, and ultimately fatal, chronic interstitial lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar epithelial injury triggers the early development of fibrosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2aaa7161477364d45984b27f5890d21
https://doi.org/10.1016/j.rmed.2018.12.015
https://doi.org/10.1016/j.rmed.2018.12.015
Autor:
Peter Heukels, K. A. Boomars, Prewesh Chandoesing, Mirjam Kool, L M van den Toorn, A E Van Den Bosch, Eric Boersma, J. A. C. van Hulst, Vivan J.M. Baggen, Rudolf W. Hendriks, Thomas Koudstaal, Laurie W Geenen, D. van Uden, Ingrid M. Bergen
Publikováno v:
Respiratory Research, 22(1):137. BioMed Central Ltd.
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Respiratory Research
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Respiratory Research
Background Recent studies have provided evidence for an important contribution of the immune system in the pathophysiology of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). In this report, we investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b878201a2dd62beea9fed2f6beee4dc
https://pure.eur.nl/en/publications/6d58687c-c102-4f7a-aae7-0fa331369788
https://pure.eur.nl/en/publications/6d58687c-c102-4f7a-aae7-0fa331369788
Aberrant B Cell Receptor Signaling in Naïve B Cells from Patients with Idiopathic Pulmonary Fibrosis
Autor:
Jennifer A C van Hulst, Jasper Rip, Odilia B. J. Corneth, Marlies S. Wijsenbeek, Peter Heukels, Rudi W. Hendriks, Stefan F H Neys
Publikováno v:
Cells
Volume 10
Issue 6
Cells, 10(6):1321. Multidisciplinary Digital Publishing Institute (MDPI)
Cells, Vol 10, Iss 1321, p 1321 (2021)
Volume 10
Issue 6
Cells, 10(6):1321. Multidisciplinary Digital Publishing Institute (MDPI)
Cells, Vol 10, Iss 1321, p 1321 (2021)
Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease in which an impaired healing response to recurrent micro-injuries is thought to lead to fibrosis. Recent findings hint at a role for B cells and autoimmunity in IPF pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd0aac186eb71874085deeb626bbc33
https://pubmed.ncbi.nlm.nih.gov/34073225
https://pubmed.ncbi.nlm.nih.gov/34073225