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Autor:
Thomas Pabst, Vito LaVopa, Serge H. Boyer, Michel Goldbach, Maria Vasiloiu, André H.M. de Vries, Peter Poechlauer, Christopher Zinganell, Stefan Steinhofer, Peter Hermsen, Ulfried Felfer, Christian Schuster, Scott J. Hecker, Andreas Pelz, Clemens Stueckler, Bas Ritzen, Georg Winkler
Publikováno v:
Organic Process Research & Development. 23:1069-1077
Within this paper, we present the design, development, and scale-up of a process for a continuous Matteson reaction to produce a key intermediate toward the β-lactamase inhibitor vaborbactam. This includes the successful implementation of the contin