Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Peter Heppner"'
Autor:
Elizabeth Cooper, Caitlin R. M. Oyagawa, Rebecca Johnson, Peter J. Choi, Jena Macapagal Foliaki, Jason Correia, Patrick Schweder, Peter Heppner, Edward Mee, Clinton Turner, Richard Faull, William A. Denny, Mike Dragunow, Jiney Jose, Thomas I-H. Park
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Glioblastoma is the most common and aggressive primary brain tumour in adults. The development of anti-brain cancer agents are challenged by the blood-brain barrier and the resistance conferred by the local tumour microenvironment. Heptameth
Externí odkaz:
https://doaj.org/article/e89e926fe6974ecaa78c8ebfb63ce277
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-6 (2022)
Abstract Background We report a case of recurrent primary intraventricular synovial sarcoma of the brain with no extracranial primary, initially reported as a haemangiopericytoma. We believe this is the first reported case of primary intraventricular
Externí odkaz:
https://doaj.org/article/d48e02dd6cc7442eaf2cb68988c23449
Autor:
Taylor J. Stevenson, Rebecca H. Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C. D. Smyth, Helen C. Murray, Richard L. M. Faull, Jason Correia, Patrick Schweder, Peter Heppner, Clinton Turner, Ronald Melki, Birger V. Dieriks, Maurice A. Curtis, Michael Dragunow
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Parkinson’s disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn). Pericytes and microglia, two non-neuronal cells contain α-syn in the human brain, how
Externí odkaz:
https://doaj.org/article/0a4e76a833d74d76a95832207eacbaf4
Autor:
Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Smyth et al. use tissue microarrays from Alzheimer’s disease (AD) patient brains to show that PDGF-BB:PDGFRβ signalling components are reduced in AD. They then use primary human brain pericytes to elucidate a pathway by which PDGF-BB:PDGFRβ signa
Externí odkaz:
https://doaj.org/article/ac4315ac00c245ed917bf0edddaef79a
Autor:
Deidre Jansson, Victor Birger Dieriks, Justin Rustenhoven, Leon C. D. Smyth, Emma Scotter, Miranda Aalderink, Sheryl Feng, Rebecca Johnson, Patrick Schweder, Edward Mee, Peter Heppner, Clinton Turner, Maurice Curtis, Richard Faull, Mike Dragunow
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Jansson et al. design a high content screening system to target inflammation in human brain cells of the blood–brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers. They identify cardiac glycosides as powerful regulato
Externí odkaz:
https://doaj.org/article/16813cdb8f5946e8a7e3b8526d12998c
Autor:
Abdel-Hameed Dabbour, Sheryl Tan, Sang Ho Kim, Sarah-Jane Guild, Peter Heppner, Daniel McCormick, Bryon E. Wright, Dixon Leung, Robert Gallichan, David Budgett, Simon C. Malpas
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Technological advancements in electronics and micromachining now allow the development of discrete wireless brain implantable micro-devices. Applications of such devices include stimulation or sensing and could enable direct placement near regions of
Externí odkaz:
https://doaj.org/article/41ed5a6e68f44e9294899682601285f7
Autor:
Justin Rustenhoven, Amy M. Smith, Leon C. Smyth, Deidre Jansson, Emma L. Scotter, Molly E. V. Swanson, Miranda Aalderink, Natacha Coppieters, Pritika Narayan, Renee Handley, Chris Overall, Thomas I. H. Park, Patrick Schweder, Peter Heppner, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-16 (2018)
Abstract Background Microglia play critical roles in the brain during homeostasis and pathological conditions. Understanding the molecular events underpinning microglial functions and activation states will further enable us to target these cells for
Externí odkaz:
https://doaj.org/article/61d01fe126004e1d9256ea1766c25fa5
Autor:
Thomas I.-H. Park, Leon C. D. Smyth, Miranda Aalderink, Zoe R. Woolf, Justin Rustenhoven, Kevin Lee, Deidre Jansson, Amy Smith, Sheryl Feng, Jason Correia, Peter Heppner, Patrick Schweder, Edward Mee, Mike Dragunow
Publikováno v:
Nature Protocols. 17:190-221
When modeling disease in the laboratory, it is important to use clinically relevant models. Patient-derived human brain cells grown in vitro to study and test potential treatments provide such a model. Here, we present simple, highly reproducible coo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01203b468e4e91b5c4fff19aab190b44
https://doi.org/10.1038/s41596-021-00637-8
https://doi.org/10.1038/s41596-021-00637-8
Autor:
Elizabeth Cooper, Zoe Woolf, Molly E V Swanson, Jason Correia, Patrick Schweder, Edward Mee, Peter Heppner, Clinton Turner, Richard L M Faull, Emma L Scotter, William A Denny, Peter J Choi, Mike Dragunow, Jiney Jose, Thomas I-H Park
Publikováno v:
Neuro-oncology advances. 4(1)
Background Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Whilst the role of the efflux transporters are well established in GBM, the expression and function of uptake transporters, such as the organic anion trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ba4f12f6c5b1784b74ce1ee4dba602
https://pubmed.ncbi.nlm.nih.gov/36382105
https://pubmed.ncbi.nlm.nih.gov/36382105
Autor:
Cenny Taslim, Julia Selich-Anderson, Megann A. Boone, James Hamill, Peter Heppner, Mark Winstanley, Andrew C. Wood, Stephen L. Lessnick, Jesse C. Crow, Mike Watson
Publikováno v:
Molecular Cancer Research. 19:1795-1801
Ewing sarcoma is a pediatric bone cancer defined by a chromosomal translocation fusing one of the FET family members to an ETS transcription factor. There have been seven reported chromosomal translocations, with the most recent reported over a decad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::218c047e9357dc35869da83051a6d08e
https://doi.org/10.1158/1541-7786.mcr-21-0354
https://doi.org/10.1158/1541-7786.mcr-21-0354