Tissue Distribution and Receptor Activation by Somapacitan, a Long Acting Growth Hormone Derivative

Autor: Maj Petersen, Prafull S. Gandhi, Jens Buchardt, Tomas Alanentalo, Johannes Josef Fels, Nils Langeland Johansen, Peter Helding-Kvist, Knud Vad, Peter Thygesen

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4, p 1181 (2020)

Somapacitan is a long-acting, once-weekly, albumin-binding growth hormone (GH) derivative. The reversible albumin-binding properties leads to prolonged circulation half-life. Here, we investigated and compared somapacitan with human GH on downstream

Externí odkaz: https://doaj.org/article/b6e20898e3814bc7a7e1b4d981469a96

Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Autor: Thomas Lindebo Holm, Ditte Tornehave, Henrik Søndergaard, Peter Helding Kvist, Bodil-Cecilie Sondergaard, Lene Hansen, Mette Brunsgaard Hermit, Kristine Holgersen, Sandra Vergo, Klaus Stensgaard Frederiksen, Claus Haase, Dorthe Lundsgaard

Publikováno v: Gastroenterology Research and Practice, Vol 2018 (2018)

Background and Aim. Interleukin-21 (IL-21) is primarily a T cell-derived cytokine; it is upregulated in patients with Crohn’s Disease (CD) and could be a potential new therapeutic target in CD. Methods. In human material, IL-21 and IL-21R expressio

Externí odkaz: https://doaj.org/article/754172b7ee274a7ea49e758f08ef3c8d

Tissue Distribution and Receptor Activation by Somapacitan, a Long Acting Growth Hormone Derivative

Autor: Tomas Alanentalo, Nils Langeland Johansen, Jens Buchardt, Knud Vad, Peter Thygesen, Prafull S. Gandhi, Johannes Josef Fels, Maj Petersen, Peter Helding-Kvist

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4, p 1181 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 4

Somapacitan is a long-acting, once-weekly, albumin-binding growth hormone (GH) derivative. The reversible albumin-binding properties leads to prolonged circulation half-life. Here, we investigated and compared somapacitan with human GH on downstream

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7858fd82c1582eb0b5f986f6b7db2a5f
https://www.mdpi.com/1422-0067/21/4/1181

Inhibitors of the renin-angiotensin system ameliorates clinical and pathological aspects of experimentally induced nephrotoxic serum nephritis

Autor: E. G. Petersen, Maria Elm Ougaard, Henrik Jeldtoft Jensen, I. D. Thuen, Peter Helding Kvist

Publikováno v: Renal Failure, Vol 40, Iss 1, Pp 640-648 (2018)
Ougaard, M E, Jensen, H E, Thuen, I D, Petersen, E G & Kvist, P H 2018, ' Inhibitors of the renin-angiotensin system ameliorates clinical and pathological aspects of experimentally induced nephrotoxic serum nephritis ', Renal Failure, vol. 40, no. 1, pp. 640-648 . https://doi.org/10.1080/0886022X.2018.1533867
Renal Failure

INTRODUCTION: Chronic kidney disease (CKD) is a global health concern, but the current treatments only slow down the progression. Thus an improved understanding of the pathogenesis and novel treatments of CKD are needed. The nephrotoxic nephritis (NT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca0c997c31de55763a4f62227b547b3
https://doi.org/10.1080/0886022x.2018.1533867

Objective Quantification of Immune Cell Infiltrates and Epidermal Proliferation in Psoriatic Skin: A Comparison of Digital Image Analysis and Manual Counting

Autor: Peter Helding Kvist, Ole Haagen Nielsen, Mads A. Røpke, Christoffer Soendergaard, Jakob Benedict Seidelin, Kresten Skak

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 24:453-458

Digital pathology and image analysis have developed extensively during the last couple of years. Especially the advance in whole-slide scanning, software, and computer processing makes it possible to apply these methods in tissue-based research. Toda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e9b152817ecb9c6153fbe997324c82
https://doi.org/10.1097/pai.0000000000000191