Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Peter Heining"'
Autor:
Anne Chester, Curtis Colleton, Michael J. Graziano, David O. Clarke, Peter Heining, David W. Brewster, Andrew J. Olaharski
Publikováno v:
Toxicologic Pathology. 44:458-466
The use of minipigs in preclinical safety testing of pharmaceuticals is considered an alternative to the more traditional dog and nonhuman primate (NHP) nonrodent species. Substantial evidence exists to suggest that the anatomy, physiology, and bioch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482e64815a4d650e7fbb82269ac5c458
https://doi.org/10.1177/0192623315617562
https://doi.org/10.1177/0192623315617562
Autor:
Tristan Ruysschaert, Peter Heining
Publikováno v:
Toxicologic Pathology. 44:467-473
The pig was introduced more than 20 years ago in drug development following attempts of finding a species that shares better homology with human than the dog, based on biophysiological parameters. However, miniaturization, standardized breeding, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a24720db7cfb50adcc4e42b85ed5d3
https://doi.org/10.1177/0192623315610823
https://doi.org/10.1177/0192623315610823
Autor:
Gordon Francis, Jeffrey A. Cohen, Ludwig Kappos, Gideon Koren, Xiaoli Zhang, Goeril Karlsson, William Collins, Peter Heining
Publikováno v:
Neurology. 82:674-680
Objective: To report outcomes of pregnancies that occurred during the fingolimod clinical development program. Methods: Pregnancy outcomes from phase II, phase III, and phase IV clinical studies (with optional extensions) were reported by clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1379c66f2ee457172d5b18cfefa4a21b
https://doi.org/10.1212/wnl.0000000000000137
https://doi.org/10.1212/wnl.0000000000000137
Autor:
Robert Schmouder, Andreas Billich, Gordon Francis, Thomas Baumruker, Pascale Burtin, Shreeram Aradhye, Peter Heining, Volker Brinkmann
Publikováno v:
Nature Reviews Drug Discovery. 9:883-897
The discovery of fingolimod (FTY720/Gilenya; Novartis), an orally active immunomodulatory drug, has opened up new approaches to the treatment of multiple sclerosis, the most common inflammatory disorder of the central nervous system. Elucidation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cb0ef258af7385bfeb53910be2c12f
https://doi.org/10.1038/nrd3248
https://doi.org/10.1038/nrd3248
Publikováno v:
Toxicologic pathology. 44(3)
Minipigs are increasingly being used as an alternative to dog or monkey in nonclinical safety testing of pharmaceuticals since they share similar anatomical and physiological characteristics to humans. Integrative assessment of pharmacodynamic and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfa742f582e52cf3b7d530136f0d0d8
https://pubmed.ncbi.nlm.nih.gov/26698323
https://pubmed.ncbi.nlm.nih.gov/26698323
Autor:
Thomas Kissner, Joanna L Parish, Jeanet Løgsted, Silvana Venturella, Anette Blak Grossi, Sofiene Mhedhbi, Jorgen Schützsack, Julia Schlichtiger, Noel Downes, Claudia Stark, Peter Heining, David Cameron, Manual Sanchez-Felix, Warren Harvey, Matthias Festag, Ingrid Brück Bøgh, Vanessa Ross, Stéphane Milano, Margaret Weaver
Publikováno v:
Toxicologic pathology. 44(3)
Minipigs have been used for dermal drug development studies for decades, and they are currently more frequently considered as the second nonrodent species for pivotal nonclinical studies, in lieu of the dog or nonhuman primate, for compounds delivere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9317c2b3a21efbe5bbb662a8fc1a940d
https://pubmed.ncbi.nlm.nih.gov/26674803
https://pubmed.ncbi.nlm.nih.gov/26674803
Autor:
Peter Heining, Suzette M. Mis, Philip J. Lowe, Guy M. L. Meno-Tetang, Nancy A. Pyszczynski, Hongshan Li, William J. Jusko
Publikováno v:
Drug Metabolism and Disposition. 34:1480-1487
FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) is a new sphingosine-1-phosphate receptor agonist being developed for multiple sclerosis and prevention of solid organ transplant rejection. A physiologically based pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf819c83e1a053e3c13445120794838
https://doi.org/10.1124/dmd.105.009001
https://doi.org/10.1124/dmd.105.009001
Autor:
Peter Heining, Noriyuki Arima, Hongshan Li, Guy M. L. Meno-Tetang, William J. Jusko, Kenji Chiba
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:519-526
The pharmacokinetics and cell trafficking dynamics of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (FTY720), a novel immunosuppressive agent, were examined in cynomolgus monkeys (three males and three females). After single doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21c98b84b296d458532a90f6b9a588d
https://doi.org/10.1124/jpet.301.2.519
https://doi.org/10.1124/jpet.301.2.519
Autor:
J. Mark Hexham, Peter Heining, Alan Slade, Guido Junge, Candace Wang, Marc I Lorber, Ronald G. Van Valen
Publikováno v:
Textbook of Organ Transplantation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb6fed9d42374e13887dbdbfc30a5c4
https://doi.org/10.1002/9781118873434.ch141
https://doi.org/10.1002/9781118873434.ch141
Autor:
David W. Holt, Peter Heining, Nicholas D. Carter, Gurcharan Merton, Maria J. Lerena, Salim Fredericks
Publikováno v:
Clinica Chimica Acta. 304:65-74
Animal models are important for the investigation of human heart pathology, novel treatments, and medical or surgical interventions for disease. Serum markers of myocardial damage may also be important tools within this field of research. In order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da722a24a1edd01eac629b71acf490d8
https://doi.org/10.1016/s0009-8981(00)00409-5
https://doi.org/10.1016/s0009-8981(00)00409-5