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Identification of oxidative modifications of hemopexin and their predicted physiological relevance

Autor: Rachel Hunt, Andrew Skaff, Edward S. Bjes, Ann Smith, J. Andrew Keightley, Peter Hahl

Publikováno v: Journal of Biological Chemistry. 292:13658-13671

Hemopexin protects against heme toxicity in hemolytic diseases and conditions, sepsis, and sickle cell disease. This protection is sustained by heme-hemopexin complexes in biological fluids that resist oxidative damage during heme-driven inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c54b88542057bdd96d47bb5916aba73
https://doi.org/10.1074/jbc.m117.783951

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Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states

Autor: Ann Smith, Peter Hahl, Jack T. Rogers, Cecilia Washburn, Taron Davis

Hemopexin provides neuroprotection in mouse models of stroke and intracerebral hemorrhage and protects neurons in vitro against heme or reactive oxygen species (ROS) toxicity via heme oxygenase-1 (HO1) activity. To model human brain neurons experienc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b74e8d3ec8f2b8f689811139bf7b94
https://europepmc.org/articles/PMC3752430/

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