Anti-leukemic effect of CDK9 inhibition in T-cell prolymphocytic leukemia

Autor: Patricia Johansson, Laura Dierichs, Ludger Klein-Hitpass, Anke K. Bergmann, Michael Möllmann, Sascha Menninger, Peter Habenberger, Bert Klebl, Jens T. Siveke, Ulrich Dührsen, Axel Choidas, Jan Dürig

Publikováno v: Therapeutic Advances in Hematology, Vol 11 (2020)

T-cell prolymphocytic leukemia (T-PLL) is an aggressive malignancy characterized by chemotherapy resistance and a median survival of less than 2 years. Here, we investigated the pharmacological effects of the novel highly specific cyclin-dependent ki

Externí odkaz: https://doaj.org/article/dbaad95c53fa476da2bd0fedf8b2e735

Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form

Autor: Thomas Ihle Aarhus, Frithjof Bjørnstad, Camilla Wolowczyk, Kristin Uhlving Larsen, Line Rognstad, Trygve Leithaug, Anke Unger, Peter Habenberger, Alexander Wolf, Geir Bjørkøy, Clare Pridans, Jan Eickhoff, Bert Klebl, Bård H. Hoff, Eirik Sundby

Publikováno v: Aarhus, T I, Bjørnstad, F, Wolowczyk, C, Larsen, K U, Rognstad, L, Leithaug, T, Unger, A, Habenberger, P, Wolf, A, Bjørkøy, G, Pridans, C, Eickhoff, J, Klebl, B, Hoff, B H & Sundby, E 2023, ' Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form ', Journal of Medicinal Chemistry, vol. 66, no. 10, pp. 6959-6980 . https://doi.org/10.1021/acs.jmedchem.3c00428

Colony-stimulating factor-1 receptor (CSF1R) is a receptor tyrosine kinase that controls the differentiation and maintenance of most tissue-resident macrophages, and the inhibition of CSF1R has been suggested as a possible therapy for a range of huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eadb975b45033dbb1fd91897a1eaf34
https://hdl.handle.net/20.500.11820/1b3ebb9b-cf94-456a-948e-bbbf0e0e8792

White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy

Autor: Edgar Dahl, Sophia Villwock, Peter Habenberger, Axel Choidas, Michael Rose, Bert M. Klebl

Publikováno v: Cancers 14(18), 4386 (2022). doi:10.3390/cancers14184386

Cancers 14(18), 4386 (2022). doi:10.3390/cancers14184386
Published by MDPI, Basel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76887e09ad7220e2a133543ec68f96be
https://pubmed.ncbi.nlm.nih.gov/36139547

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction

Autor: Bert Klebl, Hans R. Schöler, Herbert Waldmann, Matthias Baumann, Gisbert Schneider, Jared Sterneckert, Lea Kremer, Susanne Kordes, Peter Habenberger, Carsten Schultz-Fademrecht, Slava Ziegler, Axel Choidas

Publikováno v: Angewandte Chemie International Edition. 56:13021-13025

Cell-based assays enable monitoring of small-molecule bioactivity in a target-agnostic manner and help uncover new biological mechanisms. Subsequent identification and validation of the small-molecule targets, typically employing proteomics technique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bd91305b43bae1ff7804c46846ea56
https://doi.org/10.1002/anie.201707394

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps

Autor: Peter Nussbaumer, Jan Eickhoff, Gabriel Sollberger, Axel Choidas, Arturo Zychlinsky, Renate Krüger, Garth L. Burn, Peter Habenberger, Sascha Menninger, Raffaella Di Lucrezia, Bert Klebl, Alf Herzig, Susanne Kordes

Publikováno v: Science Immunology. 3

The death of a cell is an inevitable part of its biology. During homeostasis, most cells die through apoptosis. If homeostasis is disturbed, cell death can switch to proinflammatory forms of death, such as necroptosis, pyroptosis, or NETosis. We demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90535155c0fad6962731f6ea45cdae3
https://doi.org/10.1126/sciimmunol.aar6689