Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Peter Haahr"'
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Akademický článek
FBH1 Catalyzes Regression of Stalled Replication Forks
Autor: Kasper Fugger, Martin Mistrik, Kai J. Neelsen, Qi Yao, Ralph Zellweger, Arne Nedergaard Kousholt, Peter Haahr, Wai Kit Chu, Jiri Bartek, Massimo Lopes, Ian D. Hickson, Claus Storgaard Sørensen
Publikováno v: Cell Reports, Vol 10, Iss 10, Pp 1749-1757 (2015)
DNA replication fork perturbation is a major challenge to the maintenance of genome integrity. It has been suggested that processing of stalled forks might involve fork regression, in which the fork reverses and the two nascent DNA strands anneal. He
Externí odkaz: https://doaj.org/article/3fc71f988a5d4155a5e024d81cc079aa
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3
Akademický článek
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4
Clinical progression, disease severity, and mortality among adults hospitalized with COVID-19 caused by the Omicron and Delta SARS-CoV-2 variants:A population-based, matched cohort study
Autor: Harboe, Zitta Barrella, Roed, Casper, Holler, Jon Gitz, Khan, Fahim Iqbal, Abdulrahman, Aya Nihad Abdulrahman, Mulverstedt, Stefan Lundby, Lindgaard-Jensen, Betina, Bertelsen, Barbara Bonnesen, Søborg, Christian, Nielsen, Thyge Lynghøj, Hansen, Line Vinum, Madsen, Birgitte Lindegaard, Browatzki, Andrea, Eiberg, Mads, Bernhard, Peter Haahr, Pedersen, Emilie Marie Juelstorp, Egelund, Gertrud Baunbaek, Dungu, Arnold Matovu, Sejdic, Adin, Mathiesen, Inger Hee Mabuza, Jespersen, Naja Z., Petersen, Pelle Trier, Nielsen, Lars, Jepsen, Micha Phill Grønholm, Pedersen, Thomas Ingemann, Eriksson, Robert, Seitz-Rasmussen, Hans Eric Sebastian, Bestle, Morten, Andersen, Henrik, Skram, Ulrik, Skøtt, Mads Rømer, Altaraihi, Sarah, Sivapalan, Pradeesh, Jensen, Jens Ulrik Stæhr, Bagge, Kristian, Jørgensen, Kristina Melbardis, Knudsen, Maja Johanne Søndergaard, Leineweber, Thomas, Schneider, Uffe Vest, Ahlstrom, Magnus Glindvad, Rytter, Sofie, Le Dous, Nina, Ravn, Pernille, Reiter, Nanna, Podlekareva, Daria, Knudsen, Andreas, Johnsen, Stine, Kristensen, Lars Erik, Leding, Cæcilie, Hertz, Bastian Bryan, Benfield, Thomas, Kirk, Ole, Ostrowski, Sisse Rye, Sigurdsson, Sigurdur Thor, Perner, Anders, Kirkby, Nikolai, Pedersen, Martin Schou, Van Wijhe, Maarten, Simonsen, Lone, Bager, Peter Michael, Krause, Tyra Grove, Voldstedlund, Marianne, Christiansen, Lasse Engbo, Stegger, Marc, Cohen, Arieh, Fonager, Jannik, Fomsgaard, Anders, Legarth, Rebecca, Rasmussen, Morten, Gubbels, Sophie, Wohlfahrt, Jan, Lillebæk, Troels, Johannesen, Caroline Klint, Fischer, Thea K.
Publikováno v: Harboe, Z B, Roed, C, Holler, J G, Khan, F I, Abdulrahman, A N A, Mulverstedt, S L, Lindgaard-Jensen, B, Bertelsen, B B, Søborg, C, Nielsen, T L, Hansen, L V, Madsen, B L, Browatzki, A, Eiberg, M, Bernhard, P H, Pedersen, E M J, Egelund, G B, Dungu, A M, Sejdic, A, Mathiesen, I H M, Jespersen, N Z, Petersen, P T, Nielsen, L, Jepsen, M P G, Pedersen, T I, Eriksson, R, Seitz-Rasmussen, H E S, Bestle, M, Andersen, H, Skram, U, Skøtt, M R, Altaraihi, S, Sivapalan, P, Jensen, J U S, Bagge, K, Jørgensen, K M, Knudsen, M J S, Leineweber, T, Schneider, U V, Ahlstrom, M G, Rytter, S, Le Dous, N, Ravn, P, Reiter, N, Podlekareva, D, Knudsen, A, Johnsen, S, Kristensen, L E, Leding, C, Hertz, B B, Benfield, T, Kirk, O, Holler, J G, Ostrowski, S R, Sigurdsson, S T, Perner, A, Kirkby, N, Pedersen, M S, Van Wijhe, M, Simonsen, L, Bager, P M, Krause, T G, Voldstedlund, M, Christiansen, L E, Stegger, M, Cohen, A, Fonager, J, Fomsgaard, A, Legarth, R, Rasmussen, M, Gubbels, S, Wohlfahrt, J, Lillebæk, T, Johannesen, C K, Van Wijhe, M & Fischer, T K 2023, ' Clinical progression, disease severity, and mortality among adults hospitalized with COVID-19 caused by the Omicron and Delta SARS-CoV-2 variants : A population-based, matched cohort study ', PLoS ONE, vol. 18, no. 4, e0282806 . https://doi.org/10.1371/journal.pone.0282806
Background To compare the intrinsic virulence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant with the delta variant in hospitalized adults with coronavirus disease 2019 (COVID-19). Methods All adults hospitalized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2751::913a17bbd20d93a04b1765f33adc788a
https://curis.ku.dk/ws/files/359238893/journal.pone.0282806_1_.pdf
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5
ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle
Autor: Cathrine Nordgaard, Anna Constance Vind, Amy Stonadge, Rasmus Kjøbsted, Goda Snieckute, Pedro Antas, Melanie Blasius, Marie Sofie Reinert, Ana Martinez Del Val, Dorte Breinholdt Bekker‐Jensen, Peter Haahr, Yekaterina A Miroshnikova, Abdelghani Mazouzi, Sarah Falk, Emeline Perrier‐Groult, Christopher Tiedje, Xiang Li, Jens Rithamer Jakobsen, Nicolas Oldenburg Jørgensen, Jørgen FP Wojtaszewski, Frederic Mallein‐Gerin, Jesper Løvind Andersen, Cristian Pablo Pennisi, Christoffer Clemmensen, Moustapha Kassem, Abbas Jafari, Thijn Brummelkamp, Vivian SW Li, Sara A Wickström, Jesper Velgaard Olsen, Gonzalo Blanco, Simon Bekker‐Jensen
Publikováno v: EMBO Journal
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', E M B O Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J F, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', The EMBO Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction-induced p38 and JNK signaling ensure adaptation to exercise, muscle repair, and hypertrophy. How
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156c500b42a0371cbd16c762afce2461
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6
Actin maturation requires the ACTMAP/C19orf54 protease
Autor: Peter Haahr, Ricardo A. Galli, Lisa G. van den Hengel, Onno B. Bleijerveld, Justina Kazokaitė-Adomaitienė, Ji-Ying Song, Lona J. Kroese, Paul Krimpenfort, Marijke P. Baltissen, Michiel Vermeulen, Coen A. C. Ottenheijm, Thijn R. Brummelkamp
Publikováno v: Science, 377, 6614, pp. 1533-1537
Haahr, P, Galli, R A, van den Hengel, L G, Bleijerveld, O B, Kazokaitė-Adomaitienė, J, Song, J-Y, Kroese, L J, Krimpenfort, P, Baltissen, M P, Vermeulen, M, Ottenheijm, C A C & Brummelkamp, T R 2022, ' Actin maturation requires the ACTMAP/C19orf54 protease ', Science, vol. 377, no. 6614, pp. 1533-1537 . https://doi.org/10.1126/science.abq5082
Science, 377(6614), 1533-1537. American Association for the Advancement of Science
Science, 377, 1533-1537
Protein synthesis generally starts with a methionine that is removed during translation. However, cytoplasmic actin defies this rule because its synthesis involves noncanonical excision of the acetylated methionine by an unidentified enzyme after tra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09eb57498d9d31af01e63c4e9f39d32
https://repository.ubn.ru.nl/handle/2066/284057
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Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway
Autor: Ulrike Kühbacher, Irene Gallina, Julio C Y Liu, Yoshiaki Azuma, Nicolai B. Larsen, Claire Guérillon, Nikoline Borgermann, Niels Mailand, Ronald T. Hay, Emma Branigan, Leena Ackermann, Dimitriya H Garvanska, Ivo A. Hendriks, Michael L. Nielsen, Peter Haahr, Julien P. Duxin
Publikováno v: Liu, J C Y, Kühbacher, U, Larsen, N B, Borgermann, N, Garvanska, D H, Hendriks, I A, Ackermann, L, Haahr, P, Gallina, I, Guérillon, C, Branigan, E, Hay, R T, Azuma, Y, Nielsen, M L, Duxin, J P & Mailand, N 2021, ' Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway ', E M B O Journal, vol. 40, e107413 . https://doi.org/10.15252/embj.2020107413
The EMBO Journal
DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fd624e33a326d63e7e57078ba37ff6
https://curis.ku.dk/ws/files/280729418/embj.2020107413.pdf
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FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease
Autor: Niels Mailand, Marta Gallo, Fabian Coscia, Nicholas M.I. Taylor, Matthias Mann, Peter Haahr, Satyakrishna Pentakota, Andreas Mund, Saskia Hoffmann
Publikováno v: Hoffmann, S, Pentakota, S, Mund, A, Haahr, P, Coscia, F, Gallo, M, Mann, M, Taylor, N M I & Mailand, N 2020, ' FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease ', EMBO Reports, vol. 21, no. 10, e50662 . https://doi.org/10.15252/embr.202050662
EMBO Reports
Dominant missense mutations in the human serine protease FAM111A underlie perinatally lethal gracile bone dysplasia and Kenny–Caffey syndrome, yet how FAM111A mutations lead to disease is not known. We show that FAM111A proteolytic activity suppres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b03638cd40615b1ed54997820a49ec
https://curis.ku.dk/ws/files/250485170/embr.202050662.pdf
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Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability
Autor: Anna H. Bizard, Niels Mailand, Roshan Singh Thakur, Saskia Hoffmann, Alexandros P. Drainas, Peter Haahr, Ian D. Hickson, Divya Achuthankutty, Joachim Weischenfeldt
Publikováno v: Achuthankutty, D, Thakur, R S, Haahr, P, Hoffmann, S, Drainas, A P, Bizard, A H, Weischenfeldt, J, Hickson, I D & Mailand, N 2019, ' Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability ', The Journal of Cell Biology, vol. 218, no. 12, 3943 . https://doi.org/10.1083/jcb.201905064
The ATR kinase is a master regulator of the cellular response to DNA replication stress. Activation of ATR relies on dual pathways involving the TopBP1 and ETAA1 proteins, both of which harbor ATR-activating domains (AADs). However, the exact contrib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd138862819fba11628ef2df419e2a5
https://curis.ku.dk/portal/da/publications/regulation-of-etaa1mediated-atr-activation-couples-dna-replication-fidelity-and-genome-stability(506fa5f9-adc9-4e8e-887a-17780e4d14c9).html
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ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability
Autor: Titia K. Sixma, Nikoline Borgermann, Saskia Hoffmann, Niels Mailand, Xiaohu Guo, Divya Achuthankutty, Peter Haahr, Dimitris Typas, Robert F. Shearer
Publikováno v: Molecular Cell
Haahr, P, Borgermann, N, Guo, X, Typas, D, Achuthankutty, D, Hoffmann, S, Shearer, R, Sixma, T K & Mailand, N 2018, ' ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability ', Molecular Cell, vol. 70, no. 1, pp. 165-174 . https://doi.org/10.1016/j.molcel.2018.02.024
Deubiquitylating enzymes (DUBs) enhance the dynamics of the versatile ubiquitin (Ub) code by reversing and regulating cellular ubiquitylation processes at multiple levels. Here we discovered that the uncharacterized human protein ZUFSP (zinc finger w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde19c84214c10fd9da9d43eeeae46b4
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